Early Stage Researchers EDUCational Program on Factor VIII Immunogenicity

Project Information

EDUC8

Grant agreement ID: 859974

DOI

10.3030/859974

Project closed

EC signature date 17 December 2019

Start date 1 April 2020

End date 30 September 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 2 100 701,91

EU contribution

€ 2 100 701,91

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (22)

Second SSC activities

Organization of Second Second Short Scientific Course SSC

Dissemination report

Rreport on dissemination activities

Third SSC activities

Organisation of Second Short Scientific Course (SSC)

Participation to ECTH meeting 2023
Third SCT activities

Organisation of Third Short Course of Transferable training (SCT).

Network meetings

Report on organization Network Annual Meetings

First SSC activities

Organisation of First Short Scientific Course SSC

Participation to EAHAD meeting 2023
PhD Thesis

PhD thesis submission

Supervisory Board of the Network

Supervisory Board of the Network names of representatives

First SCT activities

Organisation of First Short Course of Transferable training (SCT) Report on activities done (M11, M18, M42)

Industrial, academic and virtual outreach: first report

Industrial, academic and virtual outreach: report

Potential inputs for policy feedback
Local training: first report

First year report on Local training

Second SCT activities

Organisation of Second Short Course of Transferable training SCT

Website
Participation to EAHAD meeting 2022
Recruitment

Report on the recruitment process including publication of call CV evaluation interview outcome final decision on the fellows

Local training: second report

Second year report on local training

Local training: third report

Third year report on Local training

Participation to EAHAD meeting 2021
Participation to ECTH meeting 2021

Open Research Data Pilot (1)

DMP

Data management Plan DMP

Publications

Peer reviewed articles (16)

Predicting inhibitor development using a random peptide phage-display library approach in the SIPPET cohort

Author(s): Shermarke Hassan, Guido Baselli, Luca Mollica, Riccardo L. Rossi, Himani Chand, Amal El-Beshlawy, Mohsen Elalfy, Vijay Ramanan, Peyman Eshghi, Mehran Karimi, Roberta Palla, Frits R. Rosendaal, Flora Peyvandi
Published in: Blood Advances, Issue 8, 2024, Page(s) 2880-2889, ISSN 2473-9529
Publisher: Elsevier Inc.
DOI: 10.1182/bloodadvances.2023011388

Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy

Author(s): Angelina Mimoun, Melissa Bou-Jaoudeh, Sandrine Delignat, Victoria Daventure, Alejandra Reyes Ruiz, Maxime Lecerf, Aurélien Azam, Remi Noe, Ivan Peyron, Olivier D. Christophe, Peter J. Lenting, Valérie Proulle, Jenny McIntosh, Amit C. Nathwani, Jordan D. Dimitrov, Cécile V. Denis, Sébastien Lacroix-Desmazes
Published in: Journal of Thrombosis and Haemostasis, Issue 21, 2024, Page(s) 2405-2417, ISSN 1538-7836
Publisher: Elsevier
DOI: 10.1016/j.jtha.2023.05.021

The tissue glycome as regulator of immune activation and tolerance mediated by C-type lectins and Siglecs

Author(s): Eleonora Nardini, Ernesto Rodriguez, Yvette van Kooyk
Published in: Seminars in Immunology, Issue 76, 2025, Page(s) 101913, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/j.smim.2024.101913

FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4

Author(s): Mariarosaria Miranda, Bjarke Endel Hansen, Batoul Wehbi, Valeria Porcheddu, Floris P.J. Van Alphen, Paul Kaijen, Karin Fijnvandraat, Sebastien Lacroix-Desmazes, Maartje Van den Biggelaar, Bernard Maillere, Jan Voorberg, EDUC Consortium
Published in: Haematologica, 2024, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286204

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Author(s): Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes
Published in: Haematologica, Issue Online ahead of print, 2024, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.286536

Microbial symphony orchestrated by mucosal IgA

Author(s): Reyes-Ruiz A, Dimitrov JD
Published in: Cell Mol Immunol, Issue 19(4), 2022, Page(s) 456-457
Publisher: -
DOI: 10.1038/s41423-021-00819-0

Sialic acid–modified der p 2 allergen exerts immunomodulatory effects on human PBMCs

Author(s): Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Hakan Kalay, Serge A. Versteeg, Joyce Lübbers, Gaby van Barneveld, Eveline R.J. Li, Sandra J. van Vliet, Ronald van Ree, Esther C. de Jong, Yvette van Kooyk
Published in: Journal of Allergy and Clinical Immunology: Global, Issue 3, 2024, Page(s) 100193, ISSN 2772-8293
Publisher: Elsevier
DOI: 10.1016/j.jacig.2023.100193

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A

Author(s): Ilja Oomen, Marieke Verhagen, Mariarosaria Miranda, Peter Allacher, Erik A. M. Beckers, Nicole M. A. Blijlevens, Johanna G. van der Bom, Michiel Coppens, Mariëtte Driessens, Jeroen C. J. Eikenboom, Karin Fijnvandraat, Shermarke Hassan, Waander L. van Heerde, H. Louise Hooimeijer, Joop H. Jansen, Paul Kaijen, Frank W. G. Leebeek, Daniëlle Meijer, Helmut Paul, Sanna R. Rijpma, Frits R. Rosendaal,
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: the International Union of Immunological Societies (IUIS).
DOI: 10.3389/fimmu.2024.1355813

Temperature sensitivity of bat antibodies links metabolic state of bats with antigen-recognition diversity

Author(s): Nia Toshkova, Violeta Zhelyzkova, Alejandra Reyes-Ruiz, Eline Haerens, Marina de Castro Deus, Robin V. Lacombe, Maxime Lecerf, Gaelle Gonzalez, Nolwenn Jouvenet, Cyril Planchais, Jordan D. Dimitrov
Published in: Nature Communications, Issue 15, 2024, Page(s) 5878, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50316-x

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of <scp>SARS‐CoV</scp>‐2

Author(s): Cyril Planchais, Alejandra Reyes‐Ruiz, Robin Lacombe, Alessandra Zarantonello, Maxime Lecerf, Margot Revel, Lubka T. Roumenina, Boris P. Atanasov, Hugo Mouquet, Jordan D. Dimitrov
Published in: Protein Science, Issue 31, 2023, Page(s) e4447, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4447

How can polyreactive antibodies conquer rapidly evolving viruses?

Author(s): Alejandra Reyes-Ruiz, Jordan Dimitrov
Published in: Trends Immunol, Issue 42(8), 2021, Page(s) 654-657
Publisher: -
DOI: 10.1016/j.it.2021.06.008

The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes

Author(s): Valeria Porcheddu, Gautier Lhomme, Rémi Giraudet, Evelyne Correia, Bernard Maillère
Published in: Frontiers in Immunology, Issue 15, 2024, Page(s) 1345195, ISSN 1664-3224
Publisher: the International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2024.1345195

Efanesoctocog alfa: the renaissance of Factor VIII replacement therapy

Author(s): Yesim Dargaud, Alexandre Leuci, Alejandra Reyes Ruiz, Sebastien Lacroix-Desmazes
Published in: Haematologica, Issue 109(8), 2024, Page(s) 2436-2444, ISSN 0390-6078
Publisher: Ferrata Storti Foundation
DOI: 10.3324/haematol.2023.284498

Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A

Author(s): Mariarosaria Miranda, Eelke Brandsma, Lotte Robben, Helena Van Dender, Floris P.J. van Alphen, Karin Fijnvandraat, Maartje van den Biggelaar, Sebastien Lacroix-Desmazes, Robin van Bruggen, Jan Voorberg
Published in: Journal of Thrombosis and Haemostasis, 2025, ISSN 1538-7836
Publisher: Elsevier
DOI: 10.1016/j.jtha.2024.11.012

α2-3 Sialic acids-decorated allergens exert a tolerogenic effect on CD4 T cells from Der p 2 – allergic patients

Author(s): Brigitte-Carole Keumatio Doungtsop, Eleonora Nardini, Evert E. Peterse, Hakan Kalay, Serge A. Versteeg, Ronald Van Ree, Esther E.C. de Jong, Yvette Van Kooyk
Published in: International Archives of Allergy and Immunology, 2024, Page(s) 1-19, ISSN 1018-2438
Publisher: S. Karger AG
DOI: 10.1159/000543157

Binding Promiscuity of Therapeutic Factor VIII

Author(s): Alejandra Reyes Ruiz, Aishwarya S. Bhale, Krishnan Venkataraman, Jordan D. Dimitrov, Sébastien Lacroix-Desmazes
Published in: Thrombosis and Haemostasis, 2024, Page(s) Online ahead of print, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1055/a-2358-0853

Conference proceedings (1)

Induction of neonatal tolerance to therapeutic FVIII in hemophilia A

Author(s): A Ruiz Reyes, S Delignant, V Daventure, A Mimoun, D J Dimitrov, S Lacroix-Desmazes
Published in: Hämostaseologie, GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmark, Issue 43(S 01), 2023, Page(s) S37-S38
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0042-1760514