Description du projet
Les cellules pouvant inhiber l’immunité et l’inflammation sont des cibles importantes pour les thérapies cellulaires
Les cellules myéloïdes sont une partie essentielle du système immunitaire protégeant de l’infection grâce à la régulation des cellules T. Contrairement à leur rôle immunitaire naturel, les cellules myéloïdes peuvent avoir l’effet opposé dans l’auto-immunité, les maladies inflammatoires et les greffes. Les cellules appelées cellules myéloïdes régulatrices (CMR) inhibent la réponse du système immunitaire et l’inflammation pour promouvoir la tolérance. Les CMR présentent un intérêt particulier en tant que cibles pour les thérapies cellulaires et se trouvent au cœur du réseau de formation INsTRuCT. Une communication efficace, le partage de données et des compétences transférables indispensables viendront en complément de la formation intensive, scientifique, expérimental et théorique des jeunes chercheurs grâce à une éducation couvrant l’ensemble des processus européens de développement de médicaments. Le lancement rapide de carrières brillantes centrées sur les thérapies cellulaires à base de CMR pourrait avoir des répercussions importantes sur la médecine et l’économie européenne.
Objectif
Cell therapy is an active area of immunological research and represents a highly innovative and rapidly expanding sector of pharmaceutical industry. The INsTRuCT Consortium answers an unmet need in the field for postdoctoral researchers experienced in scientifically excellent research and cell therapy development. INsTRuCT draws upon complementary expertise of its academic and industrial partners to offer a unique research and training programme. INsTRuCT proposes 15 distinctive research projects based at European companies or universities recognized for their scientific achievements and innovation. INsTRuCT is structured to promote interdisciplinary and intersectoral cooperation between partners, thereby accelerating pharmaceutical development and clinical application of novel myeloid regulatory cell (MRC)-based therapies. INsTRuCT is a primarily research-based training programme, which will be complemented by theoretical and practical training opportunities. INsTRuCT will encourage a translational view of research, which will be reinforced by intersectoral secondments. Teaching transferrable and communication skills is a high priority for INsTRuCT. ESR will gain a comprehensive overview of the drug development process in Europe as it applies to cell-based therapies; hence, INsTRuCT’s graduates will be fitted for future roles as innovative leaders in the field. INsTRuCT will strengthen interactions between cooperating research groups at junior and senior levels, thereby promoting dissemination of standardized research approaches and data-sharing. Overall, INsTRuCT constitutes an original research and training concept that responds to the specific needs of a growing sector for postdoctoral scientists trained in Basic Immunology and cell therapy development. Consequently, INsTRuCT has a very high impact potential, both in terms of its scientific and technical advancements, and its future contribution to innovation and economic development within the European Union.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
93053 Regensburg
Allemagne