Descripción del proyecto
Las células que pueden suprimir la inmunidad y la inflamación son importantes dianas para las terapias celulares
Las células mieloides son una parte esencial del sistema inmunitario, ya que protegen de las infecciones mediante la regulación de las células T. A diferencia de su papel en la inmunidad natural, las células mieloides pueden tener un efecto opuesto en la autoinmunidad, las enfermedades inflamatorias y los trasplantes. Las células reguladoras mieloides (MRC, por sus siglas en inglés) inhiben la respuesta del sistema inmunitario y la inflamación para favorecer la tolerancia. Las MRC resultan especialmente interesantes como dianas para terapias celulares y son el centro de atención de la red de formación INsTRuCT. El hincapié en la comunicación eficaz, el intercambio de datos y las competencias fundamentales transferibles complementará la formación intensiva teórica y experimental de jóvenes investigadores con educación que abarca todo el proceso de desarrollo de fármacos en Europa. Un lanzamiento rápido de carreras exitosas centradas en las terapias basadas en las MRC podría tener una importante repercusión en la medicina y la economía europea.
Objetivo
Cell therapy is an active area of immunological research and represents a highly innovative and rapidly expanding sector of pharmaceutical industry. The INsTRuCT Consortium answers an unmet need in the field for postdoctoral researchers experienced in scientifically excellent research and cell therapy development. INsTRuCT draws upon complementary expertise of its academic and industrial partners to offer a unique research and training programme. INsTRuCT proposes 15 distinctive research projects based at European companies or universities recognized for their scientific achievements and innovation. INsTRuCT is structured to promote interdisciplinary and intersectoral cooperation between partners, thereby accelerating pharmaceutical development and clinical application of novel myeloid regulatory cell (MRC)-based therapies. INsTRuCT is a primarily research-based training programme, which will be complemented by theoretical and practical training opportunities. INsTRuCT will encourage a translational view of research, which will be reinforced by intersectoral secondments. Teaching transferrable and communication skills is a high priority for INsTRuCT. ESR will gain a comprehensive overview of the drug development process in Europe as it applies to cell-based therapies; hence, INsTRuCT’s graduates will be fitted for future roles as innovative leaders in the field. INsTRuCT will strengthen interactions between cooperating research groups at junior and senior levels, thereby promoting dissemination of standardized research approaches and data-sharing. Overall, INsTRuCT constitutes an original research and training concept that responds to the specific needs of a growing sector for postdoctoral scientists trained in Basic Immunology and cell therapy development. Consequently, INsTRuCT has a very high impact potential, both in terms of its scientific and technical advancements, and its future contribution to innovation and economic development within the European Union.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
93053 Regensburg
Alemania