International NETwork for training and innovations in THErapeutic RADiation

Project Information

THERADNET

Grant agreement ID: 860245

DOI 10.3030/860245

Project closed

EC signature date 9 August 2019

Start date 1 September 2019

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 4 026 324,24

EU contribution € 4 026 324,24

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Deliverables

Other (7)

Publications
Awarding doctoral degrees
THERADNET International Symposium

THERADNET International Symposium responsible beneficiaries: IC AND UZH

Description job application WP4

Description job application WP4 UZH PDE PU M2

Outreach activities
THERADNET-EACRESTRO International Conference

THERADNETEACRESTRO International Conference responsible beneficiaries UCL AND TUD

Conference abstracts

Websites, patent fillings, videos etc. (1)

First online version THERADNET website

Publications

Peer reviewed articles (24)

Mitochondrial Transfer in Cancer: A Comprehensive Review

Author(s): Luca X. Zampieri, Catarina Silva-Almeida, Justin D. Rondeau, Pierre Sonveaux
Published in: International Journal of Molecular Sciences, Issue 22/6, 2021, Page(s) 3245, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063245

Mitochondria in cancer

Author(s): Debora Grasso, Luca X. Zampieri, Tânia Capelôa, Justine A. Van de Velde, Pierre Sonveaux
Published in: Cell Stress, Issue 4/6, 2020, Page(s) 114-146, ISSN 2523-0204
Publisher: Shared Science Publishers
DOI: 10.15698/cst2020.06.221

Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity

Author(s): Kexu Xiang, Christian Kalthoff, Corinna Münch, Verena Jendrossek, and Johann Matschke
Published in: Cell Death and Disease, 2022, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-05098-9

Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.

Author(s): Tania Capeloa, Justine A. Van de Velde, Donatienne d’Hose, Sara G. Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P. Duhoux, Michael P. Murphy, Paolo E. Porporato, Bernard Gallez and Pierre Sonveaux
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194918

Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance

Author(s): Claire Beckers, Lazaros Vasilikos, Alba Sanchez Fernandez, Lorena Moor, Martin Pruschy
Published in: Radiotherapy and Oncology, Issue Volume 190, 2024, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2023.110039

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

Author(s): Sánchez-Castillo, A., Heylen, E., Hounjet, J. et al.
Published in: Br J Cancer, 2023, ISSN 1532-1827
Publisher: Springer
DOI: 10.1038/s41416-023-02553-y

Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies andliver metabolism

Author(s): Georgios Makris, Semih Kayhan, Marvin Kreuzer, Véronique Rüfenacht, Erica Faccin, Jarl Underhaug, Carmen Diez-Fernandez, Philip A. Knobel, Martin Poms, Nadine Gougeard, Vicente Rubio, Aurora Martinez, Martin Pruschy, Johannes Häberle
Published in: Cancer Communiuations, Issue 1, 2023, ISSN 2523-3548
Publisher: Wiley
DOI: 10.1002/cac2.12402

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

Author(s): Anaís Sánchez-Castillo, Marc Vooijs, Kim R. Kampen
Published in: Cancers, Issue 13/6, 2021, Page(s) 1191, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061191

Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown

Author(s): Adam Krysztofiak, Klaudia Szymonowicz, Julian Hlouschek, Kexu Xiang, Christoph Waterkamp, Safa Larafa, Isabell Goetting, Silvia Vega-Rubin-de-Celis, Carsten Theiss, Veronika Matschke, Daniel Hoffmann, Verena Jendrossek, Johann Matschke
Published in: iScience, Issue 24/11, 2021, Page(s) 103366, ISSN 2589-0042
Publisher: Cell Press (imprint of Elsevier)
DOI: 10.1016/j.isci.2021.103366

Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation

Author(s): Goetting, Isabell; Larafa, Safa; Eul, Katharina; Kunin, Mikhail; Jakob, Burkhard; Matschke, Johann; Jendrossek, Verena
Published in: Frontiers in oncology 12, 920017 (2022). doi:10.3389/fonc.2022.920017, Issue 1, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.26083/tuprints-00021747

A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance

Author(s): Götting, I.; Jendrossek, V.; Matschke, J.
Published in: Int. J. Mol. Sci., 2020, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228563

Tumor hypoxia and radiotherapy: A major driver of resistance even for novel radiotherapy modalities

Author(s): Claire Beckers, Martin Pruschy, Irene Vetrugno
Published in: Semin Cancer Biol ., Issue Vol 98, 2024, Page(s) 19-30, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2023.11.006

Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation

Author(s): Goetting, Isabell ; Larafa, Safa ; Eul, Katharina ; Kunin, Mikhail ; Jakob, Burkhard ; Matschke, Johann ; Jendrossek, Verena
Published in: Frontiers in oncology 12, 920017 (2022), Issue 1, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.26083/tuprints-00021747

Caffeic Acid Phenethyl Ester (CAPE), a natural polyphenol to increase the therapeutic window for lung adenocarcinomas

Author(s): E. Prades-Sagarra, F. Laarakker, J. Dissy, N.G. Lieuwes, R. Biemans, M. Dubail, C. Fouillade, A. Yaromina, L.J. Dubois
Published in: Radiotherapy and Oncology, 2024, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2023.110021

Oncometabolites and the response to radiotherapy

Author(s): Kexu Xiang, Verena Jendrossek, Johann Matschke
Published in: Radiation Oncology, Issue 15/1, 2020, Page(s) 7-8, ISSN 1748-717X
Publisher: BioMed Central
DOI: 10.1186/s13014-020-01638-9

Impact of small molecule‐mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism

Author(s): Makris, Georgios; Kayhan, Semih; Kreuzer, Marvin; Rüfenacht, Véronique; Faccin, Erica; Underhaug, Jarl; Diez‐Fernandez, Carmen; Knobel, Philip A; Poms, Martin; Gougeard, Nadine; Rubio, Vicente; Martinez, Aurora; Pruschy, Martin; Häberle, Johannes
Published in: Cancer Communications, Issue 1, 2023, ISSN 2523-3548
Publisher: Wiley
DOI: 10.1002/cac2.12402

Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer.

Author(s): Prades-Sagarra, È.; Yaromina, A.; Dubois, L.J
Published in: Cancers, 2023, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15092412

Roadmap for precision preclinical x-ray radiation studies

Author(s): Frank Verhaegen; Karl T Butterworth; Anthony J Chalmers; Rob P Coppes; Dirk de Ruysscher; Sophie Dobiasch; John D Fenwick; Patrick V Granton; Stefan H J Heijmans; Mark A Hill; Constantinos Koumenis; Kirsten Lauber; Brian Marples; Katia Parodi; Lucas C G G Persoon; Nick Staut; Anna Subiel; Rianne D W Vaes; Stefan van Hoof; Ioannis L Verginadis; Jan J Wilkens; Kaye J Williams; George D Wilson; Ludwi
Published in: Physics in Medicine and Biology, Issue 1, 2023, ISSN 0031-9155
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6560/acaf45

Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

Author(s): Henning, Y., Willbrand, K., Larafa, S. et al.
Published in: Cell Death Discovery, 2023, ISSN 2058-7716
Publisher: Springer
DOI: 10.1038/s41420-023-01695-5

Tumor Hypoxia and Radiotherapy: A Major Driver of Resistance Even for Novel Radiotherapy Modalities

Author(s): Claire Beckers; Martin Pruschy; Irene Vetrugno
Published in: Seminars in Cancer Biology, Issue 2, 2023, Page(s) 19-30, ISSN 1096-3650
Publisher: Elsevier
DOI: 10.1016/j.semcancer.2023.11.006

Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance

Author(s): Claire Beckers; Lazaros Vasilikos; Alba Sanchez-Fernandez; Lorena Moor; Martin Pruschy
Published in: Radiotherapy and Oncology, Issue 10, 2024, ISSN 0167-8140
Publisher: Elsevier BV
DOI: 10.1016/j.radonc.2023.110039

Meta-analysis of expression and targeting of cell adhesion associated genes in nine cancer types - a re-evaluation by our research lab

Author(s): Olegs Borodins, Felix Broghammer, Michael Seifert, Nils Cordes
Published in: Computational and Structural Biotechnology Journal, 2023, Page(s) 2824-2836, ISSN 2001-0370
Publisher: elsevier
DOI: 10.1016/j.csbj.2023.04.017

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Author(s): Yoshiyuki Henning, Ursula Sarah Blind, Safa Larafa, Johann Matschke & Joachim Fandrey
Published in: Cell Death & Disease, 2022, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-022-05121-z

Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?

Author(s): Johann Matschke, Safa Larafa, Verena Jendrossek
Published in: Biochemical Society Transactions, Issue 49/3, 2021, Page(s) 1265-1277, ISSN 0300-5127
Publisher: Portland Press, Ltd.
DOI: 10.1042/bst20200866