International NETwork for training and innovations in THErapeutic RADiation

Resultado final

Publications
Awarding doctoral degrees
THERADNET International Symposium

THERADNET International Symposium responsible beneficiaries: IC AND UZH

Description job application WP4

Description job application WP4 UZH PDE PU M2

Outreach activities
THERADNET-EACRESTRO International Conference

THERADNETEACRESTRO International Conference responsible beneficiaries UCL AND TUD

Conference abstracts

First online version THERADNET website

Publicaciones

Mitochondrial Transfer in Cancer: A Comprehensive Review

Autores: Luca X. Zampieri, Catarina Silva-Almeida, Justin D. Rondeau, Pierre Sonveaux
Publicado en: International Journal of Molecular Sciences, Edición 22/6, 2021, Página(s) 3245, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063245

Mitochondria in cancer

Autores: Debora Grasso, Luca X. Zampieri, Tânia Capelôa, Justine A. Van de Velde, Pierre Sonveaux
Publicado en: Cell Stress, Edición 4/6, 2020, Página(s) 114-146, ISSN 2523-0204
Editor: Shared Science Publishers
DOI: 10.15698/cst2020.06.221

Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivity

Autores: Kexu Xiang, Christian Kalthoff, Corinna Münch, Verena Jendrossek, and Johann Matschke
Publicado en: Cell Death and Disease, 2022, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-022-05098-9

Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.

Autores: Tania Capeloa, Justine A. Van de Velde, Donatienne d’Hose, Sara G. Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P. Duhoux, Michael P. Murphy, Paolo E. Porporato, Bernard Gallez and Pierre Sonveaux
Publicado en: Cancers, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14194918

Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance

Autores: Claire Beckers, Lazaros Vasilikos, Alba Sanchez Fernandez, Lorena Moor, Martin Pruschy
Publicado en: Radiotherapy and Oncology, Edición Volume 190, 2024, ISSN 0167-8140
Editor: Elsevier BV
DOI: 10.1016/j.radonc.2023.110039

Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer

Autores: Sánchez-Castillo, A., Heylen, E., Hounjet, J. et al.
Publicado en: Br J Cancer, 2023, ISSN 1532-1827
Editor: Springer
DOI: 10.1038/s41416-023-02553-y

Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies andliver metabolism

Autores: Georgios Makris, Semih Kayhan, Marvin Kreuzer, Véronique Rüfenacht, Erica Faccin, Jarl Underhaug, Carmen Diez-Fernandez, Philip A. Knobel, Martin Poms, Nadine Gougeard, Vicente Rubio, Aurora Martinez, Martin Pruschy, Johannes Häberle
Publicado en: Cancer Communiuations, Edición 1, 2023, ISSN 2523-3548
Editor: Wiley
DOI: 10.1002/cac2.12402

Linking Serine/Glycine Metabolism to Radiotherapy Resistance

Autores: Anaís Sánchez-Castillo, Marc Vooijs, Kim R. Kampen
Publicado en: Cancers, Edición 13/6, 2021, Página(s) 1191, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13061191

Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown

Autores: Adam Krysztofiak, Klaudia Szymonowicz, Julian Hlouschek, Kexu Xiang, Christoph Waterkamp, Safa Larafa, Isabell Goetting, Silvia Vega-Rubin-de-Celis, Carsten Theiss, Veronika Matschke, Daniel Hoffmann, Verena Jendrossek, Johann Matschke
Publicado en: iScience, Edición 24/11, 2021, Página(s) 103366, ISSN 2589-0042
Editor: Cell Press (imprint of Elsevier)
DOI: 10.1016/j.isci.2021.103366

Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation

Autores: Goetting, Isabell; Larafa, Safa; Eul, Katharina; Kunin, Mikhail; Jakob, Burkhard; Matschke, Johann; Jendrossek, Verena
Publicado en: Frontiers in oncology 12, 920017 (2022). doi:10.3389/fonc.2022.920017, Edición 1, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.26083/tuprints-00021747

A New Twist in Protein Kinase B/Akt Signaling: Role of Altered Cancer Cell Metabolism in Akt-Mediated Therapy Resistance

Autores: Götting, I.; Jendrossek, V.; Matschke, J.
Publicado en: Int. J. Mol. Sci., 2020, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21228563

Tumor hypoxia and radiotherapy: A major driver of resistance even for novel radiotherapy modalities

Autores: Claire Beckers, Martin Pruschy, Irene Vetrugno
Publicado en: Semin Cancer Biol ., Edición Vol 98, 2024, Página(s) 19-30, ISSN 1044-579X
Editor: Academic Press
DOI: 10.1016/j.semcancer.2023.11.006

Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing Radiation

Autores: Goetting, Isabell ; Larafa, Safa ; Eul, Katharina ; Kunin, Mikhail ; Jakob, Burkhard ; Matschke, Johann ; Jendrossek, Verena
Publicado en: Frontiers in oncology 12, 920017 (2022), Edición 1, 2022, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.26083/tuprints-00021747

Caffeic Acid Phenethyl Ester (CAPE), a natural polyphenol to increase the therapeutic window for lung adenocarcinomas

Autores: E. Prades-Sagarra, F. Laarakker, J. Dissy, N.G. Lieuwes, R. Biemans, M. Dubail, C. Fouillade, A. Yaromina, L.J. Dubois
Publicado en: Radiotherapy and Oncology, 2024, ISSN 0167-8140
Editor: Elsevier BV
DOI: 10.1016/j.radonc.2023.110021

Oncometabolites and the response to radiotherapy

Autores: Kexu Xiang, Verena Jendrossek, Johann Matschke
Publicado en: Radiation Oncology, Edición 15/1, 2020, Página(s) 7-8, ISSN 1748-717X
Editor: BioMed Central
DOI: 10.1186/s13014-020-01638-9

Impact of small molecule‐mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism

Autores: Makris, Georgios; Kayhan, Semih; Kreuzer, Marvin; Rüfenacht, Véronique; Faccin, Erica; Underhaug, Jarl; Diez‐Fernandez, Carmen; Knobel, Philip A; Poms, Martin; Gougeard, Nadine; Rubio, Vicente; Martinez, Aurora; Pruschy, Martin; Häberle, Johannes
Publicado en: Cancer Communications, Edición 1, 2023, ISSN 2523-3548
Editor: Wiley
DOI: 10.1002/cac2.12402

Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer.

Autores: Prades-Sagarra, È.; Yaromina, A.; Dubois, L.J
Publicado en: Cancers, 2023, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers15092412

Roadmap for precision preclinical x-ray radiation studies

Autores: Frank Verhaegen; Karl T Butterworth; Anthony J Chalmers; Rob P Coppes; Dirk de Ruysscher; Sophie Dobiasch; John D Fenwick; Patrick V Granton; Stefan H J Heijmans; Mark A Hill; Constantinos Koumenis; Kirsten Lauber; Brian Marples; Katia Parodi; Lucas C G G Persoon; Nick Staut; Anna Subiel; Rianne D W Vaes; Stefan van Hoof; Ioannis L Verginadis; Jan J Wilkens; Kaye J Williams; George D Wilson; Ludwi
Publicado en: Physics in Medicine and Biology, Edición 1, 2023, ISSN 0031-9155
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6560/acaf45

Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia

Autores: Henning, Y., Willbrand, K., Larafa, S. et al.
Publicado en: Cell Death Discovery, 2023, ISSN 2058-7716
Editor: Springer
DOI: 10.1038/s41420-023-01695-5

Tumor Hypoxia and Radiotherapy: A Major Driver of Resistance Even for Novel Radiotherapy Modalities

Autores: Claire Beckers; Martin Pruschy; Irene Vetrugno
Publicado en: Seminars in Cancer Biology, Edición 2, 2023, Página(s) 19-30, ISSN 1096-3650
Editor: Elsevier
DOI: 10.1016/j.semcancer.2023.11.006

Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance

Autores: Claire Beckers; Lazaros Vasilikos; Alba Sanchez-Fernandez; Lorena Moor; Martin Pruschy
Publicado en: Radiotherapy and Oncology, Edición 10, 2024, ISSN 0167-8140
Editor: Elsevier BV
DOI: 10.1016/j.radonc.2023.110039

Meta-analysis of expression and targeting of cell adhesion associated genes in nine cancer types - a re-evaluation by our research lab

Autores: Olegs Borodins, Felix Broghammer, Michael Seifert, Nils Cordes
Publicado en: Computational and Structural Biotechnology Journal, 2023, Página(s) 2824-2836, ISSN 2001-0370
Editor: elsevier
DOI: 10.1016/j.csbj.2023.04.017

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Autores: Yoshiyuki Henning, Ursula Sarah Blind, Safa Larafa, Johann Matschke & Joachim Fandrey
Publicado en: Cell Death & Disease, 2022, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-022-05121-z

Metabolic reprograming of antioxidant defense: a precision medicine perspective for radiotherapy of lung cancer?

Autores: Johann Matschke, Safa Larafa, Verena Jendrossek
Publicado en: Biochemical Society Transactions, Edición 49/3, 2021, Página(s) 1265-1277, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20200866

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