The life cycle of extracellular vesicles in prostate cancer: from biogenesis and homing, to functional relevance

Deliverables

Together with partner organisation Movember regular update videos from ESRs presenting major findings of the research will be prepared in a format that is accessible to the general public These videos will be made available through the project website and announced via social media

Website created and social media presence build

A project website will be developed and launched in the first quarter of the project Adequate social media accounts will be generated and maintained

Report inventory of relevant EU consortia to contact for collaborative interactions

A list will be prepared of EU research and innovation consortia for exploration of collaboration opportunities

Publications

Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author(s): González-Muñoz, Teresa Di Giannatale, Angela Garcia-Silva, Susana Santos, Vanesa Sanchez-Redondo, Sara Savini, Claudia CNIO Graña-Castro, Osvaldo CNIO Blanco-Aparicio, Carmen CNIO Fischer, Suzanne De Wever, Olivier Creus-Bachiller, Edgar Ortega-Bertran, Sara Pisapia, David J Rodríguez-Peralto, José L Fernández-Rodríguez, Juana Romagosa, Cleofe Alaggio, Rita Benassi, Maria Serena Pazzaglia,
Published in: Clinical Cancer Research, 2023, ISSN 1557-3265
Publisher: AACR
DOI: 10.1158/1078-0432.ccr-22-2462.

Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

Author(s): David Olmeda, Daniela Cerezo-Wallis, Elena Castellano-Sanz, Susana García-Silva, Héctor Peinado, María S. Soengas
Published in: Advanced Drug Delivery Reviews, Issue 175, 2021, Page(s) 113833, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.113833

Simultaneous Quantification of Steroid Hormones Using hrLC-MS in Endocrine Tissues of Male Rats and Human Samples

Author(s): Guillermo Bordanaba-Florit; Sebastiaan van Liempd; Diana Cabrera; Félix Royo; Juan Manuel Falcón-Pérez
Published in: Metabolites, 2022, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12080714

A decision support system based on artificial intelligence and systems biology for the simulation of pancreatic cancer patient status

Author(s): Valentin Junet; Pedro Matos‐Filipe; Juan Manuel García‐Illarramendi; Esther Ramírez; Baldo Oliva; Judith Farrés; Xavier Daura; José Manuel Mas; Rafael Morales
Published in: CPT: Pharmacometrics & Systems Pharmacology, 2023, ISSN 2163-8306
Publisher: Nature Publishing Group
DOI: 10.1002/psp4.12961

Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity

Author(s): Matthijs J. van Haren, Yongzhi Gao, Ned Buijs, Roberto Campagna, Davide Sartini, Monica Emanuelli, Lukasz Mateuszuk, Agnieszka Kij, Stefan Chlopicki, Pol Escudé Martinez de Castilla, Raymond Schiffelers, Nathaniel I. Martin
Published in: Biomolecules, Issue 11/9, 2021, Page(s) 1357, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11091357

Stroma-derived extracellular vesicle mRNA signatures inform histological nature of prostate cancer.

Author(s): Alex P. Shephard; Peter Giles; Mariama Mbengue; Amr Alraies; Lisa K. Spary; Howard Kynaston; Howard Kynaston; Mark Gurney; Juan M. Falcón-Pérez; Felix Royo; Zsuzsanna Tabi; Dimitris Parthimos; Rachel J. Errington; Aled Clayton; Jason P. Webber; Jason P. Webber
Published in: Journal of Extracellular Vesicles, 2021, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/jev2.12150

In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm

Author(s): Laura Artigas, Mireia Coma, Pedro Matos-Filipe, Joaquim Aguirre-Plans, Judith Farrés, Raquel Valls, Narcis Fernandez-Fuentes, Juan de la Haba-Rodriguez, Alex Olvera, Jose Barbera, Rafael Morales, Baldo Oliva, Jose Manuel Mas
Published in: PLOS ONE, Issue 15/10, 2020, Page(s) e0240149, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0240149

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

Author(s): Pol Escudé Martinez de Castilla, Lingjun Tong, Chenyuan Huang, Alexandros Marios Sofias, Giorgia Pastorin, Xiaoyuan Chen, Gert Storm, Raymond M. Schiffelers, Jiong-Wei Wang
Published in: Advanced Drug Delivery Reviews, 2021, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.05.011

Mast cells impair melanoma cell homing and metastasis by inhibiting HMGA1 secretion

Author(s): Alberto Benito-Martin, Laura Nogués, Marta Hergueta-Redondo, Elena Castellano-Sanz, Eduardo Garvin, Michele Cioffi, Paloma Sola-Castrillo, Weston Buehring, Pilar Ximénez-Embún, Javier Muñoz, Irina Matei, Josep Villanueva, Héctor Peinado
Published in: Immunology, 2023, ISSN 1365-2567
Publisher: Immunology
DOI: 10.1111/imm.13604

Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

Author(s): Guillermo Bordanaba-Florit, Félix Royo, Sergei G. Kruglik, Juan M. Falcón-Pérez
Published in: Nature Protocols, Issue 16/7, 2021, Page(s) 3163-3185, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-021-00551-z

Implications and pitfalls for cancer diagnostics exploiting extracellular vesicles

Author(s): Ana Špilak, Andreas Brachner, Ulrike Kegler, Winfried Neuhaus, Christa Noehammer
Published in: Advanced Drug Delivery Reviews, Issue 175, 2021, Page(s) 113819, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.05.029

3D Cell Cultures as Prospective Models to Study Extracellular Vesicles in Cancer

Author(s): Guillermo Bordanaba-Florit, Iratxe Madarieta, Beatriz Olalde, Juan M. Falcón-Pérez, Félix Royo
Published in: Cancers, Issue 13/2, 2021, Page(s) 307, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13020307

In vivo imaging of EVs in zebrafish: New perspectives from “the waterside”

Author(s): Vincenzo Verdi, Anaïs Bécot, Guillaume van Niel, Frederik J. Verweij
Published in: FASEB BioAdvances, 2021, ISSN 2573-9832
Publisher: Wiley
DOI: 10.1096/fba.2021-00081

Integrins are enriched on aberrantly fucosylated tumour-derived urinary extracellular vesicles

Author(s): Md. Khirul Islam, Bert Dhondt, Parvez Syed, Misba Khan, Kamlesh Gidwani, Jason Webber, An Hendrix, Guido Jenster, Tarja Lamminen, Peter J. Boström, Kim Pettersson, Urpo Lamminmäki, Janne Leivo
Published in: Journal of Extracellular Biology, 2022, ISSN 2768-2811
Publisher: Wiley
DOI: 10.1002/jex2.64

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

Author(s): García-Silva, Susana Benito-Martín, Alberto Nogués, Laura Hernández-Barranco, Alberto Mazariegos, Marina S. Santos, Vanesa Hergueta-Redondo, Marta Ximénez-Embún, Pilar Kataru, Raghu P. Lopez, Ana Amor Merino, Cristina Sánchez-Redondo, Sara Graña-Castro, Osvaldo CNIO Matei, Irina Nicolás-Avila, José Ángel Torres-Ruiz, Raúl Rodríguez-Perales, Sandra Martínez, Lola Pérez-Martínez, Man
Published in: Nature Cancer, 2021, ISSN 2662-1347
Publisher: Nature Cancer
DOI: 10.1038/s43018-021-00272-y

Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer

Author(s): Jasmine S. Owen; Aled Clayton; Helen B. Pearson
Published in: Biomolecules, 2023, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom13010067

Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor Signaling

Author(s): Annelies Van Hemelryk; Ingrid Tomljanovic; Corrina M. A. de Ridder; Debra C. Stuurman; Wilma J. Teubel; Sigrun Erkens-Schulze; Esther I. Verhoef; Sebastiaan Remmers; Amrish J. Mahes; Geert J. L. H. van Leenders; Martin E. van Royen; Harmen J. G. van de Werken; Magda Grudniewska; Guido W. Jenster; Wytske M. van Weerden
Published in: Cells, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11223632

Challenges and directions in studying cell-cell communication by extracellular vesicles

Author(s): Guillaume van Niel, David R F Carter, Aled Clayton, Daniel W Lambert, Graça Raposo, Pieter Vader
Published in: Nature Reviews Molecular Cell Biology, 2022, ISSN 1471-0072
Publisher: Nature Publishing Group
DOI: 10.1038/s41580-022-00460-3

Building virtual cohorts via the integration of public data

Author(s): Pedro Matos-Filipe, Juan Manuel García-Illarramendi, Baldo Oliva, Judith Farrés and José Manuel Mas
Published in: 2022, ISSN 2194-0479
Publisher: ALTEX Proceedings
DOI: 10.58847/ap.2202

The usage of transcriptomics datasets as sources of Real-World Data for clinical trialling

Author(s): Pedro Matos-Filipe, Juan Manuel García-Illarramendi, ProfileGuillem Jorba, ProfileBaldo Oliva, ProfileJudith Farrés, José Manuel Mas
Published in: bioRxiv, 2022, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2022.11.10.515995

Deliverables

Publications

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