Heterogenous biocatalytic reaction cascades training network

Deliverables

Videos and infographics Part 1
ITN Logo and Website
INTERfaces Advertisement video and infographic
Videos and infographics Part 3
Videos and infographics Part 2

Announcement of ESR positions
Dedicated session in Biocat2022

Public engagement report
Network-wide training report

Publications

Biosynthesis of Furfurylamines in Batch and Continuous Flow by Immobilized Amine Transaminases

Author(s): Tobias Heinks; Luisa M. Merz; Jan Liedtke; Matthias Höhne; Luuk M. van Langen; Uwe T. Bornscheuer; Gabriele Fischer von Mollard; Per Berglund
Published in: Catalysts, Issue 13,5, 2023, Page(s) 875, ISSN 2073-4344
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/catal13050875

Simple Plug-In Synthetic Step for the Synthesis of (−)-Camphor from Renewable Starting Materials

Author(s): Elia Calderini, Ivana Drienovská, Kamela Myrtollari, Michaela Pressnig, Volker Sieber, Helmut Schwab, Michael Hofer, Robert Kourist
Published in: ChemBioChem, Issue 22, 2021, Page(s) p. 2951-2956, ISSN 1439-7633
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cbic.202100187

A patent survey on the biotechnological production of 2,5-furandicarboxylic acid (FDCA): Current trends and challenges

Author(s): Milica Milić, Pablo Domínguez de María, Selin Kara
Published in: EFB Bioeconomy Journal, Issue 3, 2023, Page(s) 100050, ISSN 2667-0410
Publisher: Elsevier
DOI: 10.1016/j.bioeco.2023.100050

Hydrophilic Nonwoven Nanofiber Membranes as Nanostructured Supports for Enzyme Immobilization

Author(s): Antonio L. Medina-Castillo; Lucija Ruzic; Bernd Nidetzky; Juan M. Bolivar
Published in: ACS applied Polymer Materials, Issue 4,8, 2022, Page(s) 6054–6066, ISSN 2637-6105
Publisher: American Chemical Society
DOI: 10.1021/acsapm.2c00863

Overcoming biochemical limitations of galactose oxidase through the design of a solid-supported self-sufficient biocatalyst

Author(s): Lorente-Arevalo, A, Orellana, g., Ladero, Miguel, Bolivar J.M.
Published in: ChemBioChem, Issue 24,24, 2023, Page(s) e202300421, ISSN 1439-7633
Publisher: Wiley-Blackwell
DOI: 10.1002/cbic.202300421

Heterogeneous biocatalytic reduction of 5-(hydroxy)methyl furfural using two co-immobilised alcohol dehydrogenases

Author(s): Jakub F. Kornecki; André Pick; Pablo Dominguez de María; Fernando López-Gallego
Published in: RSC Sustainability, Issue 1, 2023, Page(s) 1883-1895, ISSN 2753-8125
Publisher: The Royal Society of Chemistry
DOI: 10.1039/d3su00178d

Selective Oxidation of 5-Hydroxymethylfurfural to 2,5-Diformylfuran in Biphasic Media using Immobilized Galactose Oxidase: Proof of Concept and Limitations

Author(s): Milić, M., Byström, E., Domínguez de María, P. and Kara, S.
Published in: ChemCatChem, Issue 16,4, 2023, ISSN 1867-3899
Publisher: Chemistry Europe
DOI: 10.1002/cctc.202301384

Laccases from <i>Pleurotus ostreatus</i> Applied to the Oxidation of Furfuryl Alcohol for the Synthesis of Key Compounds for Polymer Industry

Author(s): Nicoletta Cascelli; Vincenzo Lettera; Giovanni Sannia; Vicente Gotor‐Fernández; Iván Lavandera
Published in: ChemSusChem, Issue 16, 13, 2023, Page(s) e202300226, ISSN 1864-564X
Publisher: Chemistry Europe
DOI: 10.1002/cssc.202300226

Stability Increase of Phenolic Acid Decarboxylase by a Combination of Protein and Solvent Engineering Unlocks Applications at Elevated Temperatures

Author(s): Myrtollari, K., Calderini, E., Kracher, D., Schöngaßner, T., Galušić, S., Slavica, A., Taden, A., Mokos, D., Schrüfer, A., Wirnsberger, G., Gruber, K., Daniel, B., and Kourist, R.
Published in: ACS Sustainable Chemistry & Engineering, Issue 12,9, 2024, Page(s) 3575-3584, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.3c06513

FTIR microscopy for direct observation of conformational changes on immobilized ω-transaminase: effect of water activity and organic solvent on biocatalyst performance

Author(s): Iulia-Ioana Rădoi; Diana Eva Bedolla; Lisa Vaccari; Anamaria Todea; Federico Zappaterra; Alexey Volkov; Lucia Gardossi
Published in: Catalysis Science & Technology, Issue 13, 2023, Page(s) 4955-4967, ISSN 2044-4761
Publisher: Royal Society of Chemisty
DOI: 10.1039/d2cy01949c

A Multiplex Assay to Assess the Transaminase Activity toward Chemically Diverse Amine Donors

Author(s): Czarnievicz, N., Grazia Rubanu, M., Iturralde, M., Albarran-Velo, J., Diamanti, E., Gotor-Fernandez, V., Skolimowski, M. and López-Gallego, F.
Published in: ChemBioChem, Issue 16, 2, 2022, Page(s) e202200614, ISSN 1439-7633
Publisher: Chemistry Europe
DOI: 10.1002/cbic.202200614

Integrated preservation of water activity as key to intensified chemoenzymatic synthesis of bio-based styrene derivatives

Author(s): Petermeier, P., Bittner, J.P., Jonsson, T., Domínguez de María, P., Byström, E. and Kara, S.,
Published in: Communications Chemistry, Issue 7, 57, 2024, Page(s) 1-11, ISSN 2399-3669
Publisher: Nature
DOI: 10.1038/s42004-024-01138-x

2,5-Furandicarboxaldehyde as a bio-based crosslinking agent replacing glutaraldehyde for covalent enzyme immobilization

Author(s): Danielli, Chiara; van Langen, Luuk; Boes, Deborah; Asaro, Fioretta; Anselmi, Serena; Provenza, Francesca; Renzi, Monia; Gardossi, Lucia
Published in: RSC Advances, Issue 12, 2022, Page(s) 35676-35684, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ra07153c

Spectrophotometric Assay for the Detection of 2,5-Diformylfuran and Its Validation through Laccase-Mediated Oxidation of 5-Hydroxymethylfurfural

Author(s): Nicoletta Cascelli; Vicente Gotor-Fernández; Iván Lavandera; Giovanni Sannia; Vincenzo Lettera
Published in: International Journal of Molecular Sciences, Issue 24,23, 2023, Page(s) 16861, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242316861

Biotransamination of Furan‐Based Aldehydes with Isopropylamine: Enzyme Screening and pH Influence

Author(s): Antía Pintor; Nicoletta Cascelli; Alexey Volkov; Vicente Gotor‐Fernández; Iván Lavandera
Published in: ChemBioChem, Issue 24,23, 2023, Page(s) e202300514, ISSN 1439-7633
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cbic.202300514

Development of an amine transaminase-lipase cascade for chiral amide synthesis under flow conditions

Author(s): Antía Pintor; Ashley P. Mattey; Iván Lavandera; Vicente Gotor-Fernández; Alexey Volkov
Published in: Green Chemistry, Issue 25, 15, 2023, Page(s) 6041-6050, ISSN 1463-9270
Publisher: The Royal Society of Chemistry
DOI: 10.1039/d3gc02426a

Design of a green chemoenzymatic cascade for scalable synthesis of bio-based styrene alternatives

Author(s): Petermeier, Philipp; Bittner, Jan Philipp; Müller, Simon; Byström, Emil; Kara, Selin
Published in: Green chemistry : GC 24 (2022), Nr. 18, Issue 1, 2022, Page(s) 6889-6899, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2gc01629j

Exploring the in Vitro Operating Window of Glycosyltransferase PtUGT1 from Polygonum tinctorium for a Biocatalytic Route to Indigo Dye

Author(s): Philipp Petermeier, Cristina Fortuna, Kathrine M. Hübschmann, Gonzalo N. Bidart, Thomas Tørring, David Teze, Ditte H. Welner, Selin Kara
Published in: ACS Sustainable Chemistry & Engineering, Issue 9, 25, 2021, Page(s) 8497-8506, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.1c01536

Enzymatic Cascade for the Synthesis of 2,5-Furandicarboxylic Acid in Biphasic and Microaqueous Conditions: ‘Media-Agnostic’ Biocatalysts for Biorefineries

Author(s): Milica Milić, Dr. Emil Byström, Dr. Pablo Domínguez de María, Prof. Dr. Selin Kara
Published in: ChemSusChem, Issue 15, 2022, Page(s) e202102704(1 of 8), ISSN 1864-564X
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cssc.202102704

Chemoselective Lipase-Catalyzed Synthesis of Amido Derivatives from 5-Hydroxymethylfurfurylamine

Author(s): Antía Pintor; Iván Lavandera; Alexey Volkov; Vicente Gotor-Fernández
Published in: ACS Sustainable Chemistry & Engineering, Issue 11,28, 2023, Page(s) 10284-10292, ISSN 2168-0485
Publisher: American Chemical Society
DOI: 10.1021/acssuschemeng.3c00775

The Role of Buffer, Pyridoxal 5'-Phosphate and Light on the Stability of the Silicibacter Pomeroyi Transaminase

Author(s): Merz, L.M., van Langen, L.M. and Berglund, P.
Published in: ChemCatChem, Issue 15,2, 2022, Page(s) n/a - n/a, ISSN 1867-3899
Publisher: Chemistry Europe
DOI: 10.1002/cctc.202201174

Spectrophotometric and fluorimetric high-throughput assays for phenolic acid decarboxylase

Author(s): Terholsen, H., Myrtollari, K., Larva, M., Möller, C., Taden, A., Kourist, R., Bornscheuer, U.T. and Kracher, D.
Published in: ChemBioChem, Issue 24,16, 2023, Page(s) e202300207, ISSN 1439-7633
Publisher: Wiley-VCH
DOI: 10.1002/cbic.202300207

Chapter 11 – Versatility of microbial laccases in industrial applications

Author(s): Lettera, V., Cascelli, N., De Chiaro, A. and Sannia G.
Published in: Bacterial Laccases. Engineering, Immobilization, Heterologous Production, and Industrial Applications, Issue 1, 2023, Page(s) 263-332, ISBN 978-0-323-91889-3
Publisher: Elsevier Inc
DOI: 10.1016/b978-0-323-91889-3.00003-0

Enzyme Cascade Reaction Engineering

Author(s): Philipp Petermeier, Selin Kara
Published in: Enzyme Cascade Design and Modelling, Issue 1, 2021, Page(s) 109-124, ISBN 978-3-030-65717-8
Publisher: Pringer Cham
DOI: 10.1007/978-3-030-65718-5_7

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