Project description DEENESFRITPL Industrial benefits abound from enzymatic cascades of catalytic reactions inspired by nature Chemical synthesis is at the core of processes and products in industries from pharmaceuticals to polymers to sensors and energy. As the world turns to more sustainable synthetic methods, biocatalysts have claimed the spotlight. Heterogeneous biocatalysis involves the use of enzymes (protein catalysts) immobilised on solid supports. The confinement of enzymes in solid materials is inspired by the spatial organisation and compartmentalisation of metabolic pathways in cells. Now, INTERfaces is extending this concept to cascades of heterogeneous biocatalytic reactions. Building on the momentum provided by early stage researchers, the team plans to engineer cascades starting with two biobased monomers leading to the creation of products of industrial relevance. The most promising will be upscaled for commercial implementation. Show the project objective Hide the project objective Objective The INTERfaces program will train 14 ESRs within an EID network jointly designed by European academic and industry partners in innovative research projects dedicated to developing clean bioprocesses for the production of chemicals. The assembly of biocatalysts to reaction sequences allows avoiding steps for isolation and purification of intermediates and thus a significant improvement of the environmental footprint of catalytic processes. The main goal of INTERfaces is the extension of this concept towards multi-step biocatalytic reactions in immobilized form. These “Heterogeneous Biocatalytic Reaction Cascades” will greatly facilitate re-use of the catalysts and further simplify downstream-processing. INTERfaces combines material science and protein engineering to design tailored enzymes and (bio-based) materials that will complement each other to obtain optimized heterogeneous biocatalysts. These tools will be applied to solve synthetic challenges in the use of two biobased monomers as starting materials to synthesize products for application fields like antioxidants and biopolymers. Process optimization and up-scale in industry will reveal key factors for synthetic utilization of the biocatalysts. INTERfaces emphasizes particularly the engineering of the designed cascades in solid phase. This includes the design of reactors, use of computational modeling tools, application of the right operational modes, and reaction medium needed for desired space-time-yields and product titers. Commercial relevant processes will be up-scaled together with industry for technical implementation. 13 Non-academic partners ranging from high-tech SMEs to large producing companies and 9 academic institutions offer an intersectoral and interdisciplinary environment to provide 14 Ph.D. candidates with outstanding employability profiles for the European Biotech Sector. Dedicated workshops and well-balanced supervisory team aim at increasing the gender diversity in biotech research. Fields of science natural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords Biobased Chemicals Biocatalytic Cascades Biomaterials Enzyme Immobilization Biorefineries Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2019 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2019 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator AARHUS UNIVERSITET Net EU contribution € 595 044,00 Address Nordre ringgade 1 8000 Aarhus c Denmark See on map Region Danmark Midtjylland Østjylland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (17) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ACIB GMBH Austria Net EU contribution € 264 207,24 Address Krenngasse 37/2 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TECHNISCHE UNIVERSITAET GRAZ Austria Net EU contribution € 264 207,24 Address Rechbauerstrasse 12 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSIDAD DE OVIEDO Spain Net EU contribution € 250 904,88 Address Calle san francisco 3 33003 Oviedo See on map Region Noroeste Principado de Asturias Asturias Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DEGLI STUDI DI TRIESTE Italy Net EU contribution € 261 499,68 Address Piazzale europa 1 34127 Trieste See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET BIELEFELD Germany Net EU contribution € 252 788,40 Address Universitaetsstrasse 25 33615 Bielefeld See on map Region Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 KUNGLIGA TEKNISKA HOEGSKOLAN Sweden Net EU contribution € 0,00 Address Brinellvagen 8 100 44 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 VIAZYM BV Netherlands Net EU contribution € 531 239,76 Address Molengraaffsingel 10 2629 JD Delft See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region West-Nederland Zuid-Holland Delft en Westland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CASCAT GMBH Germany Net EU contribution € 252 788,40 Address Europaring 4 94315 Straubing See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Niederbayern Straubing, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ENGINZYME AB Sweden Net EU contribution € 281 982,96 Address Tomtebodavagen 6 17165 Stockholm See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SPINCHEM AB Sweden Net EU contribution € 0,00 Address Tvistevagen 48c 90736 Umea See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Norra Sverige Övre Norrland Västerbottens län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NANOMATERIALES Y POLIMEROS SL Participation ended Spain Net EU contribution € 0,00 Address Avenida de la innovacion 1, edificio bic 18100 Armilla granada See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sur Andalucía Granada Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 BIOPOX SRL Italy Net EU contribution € 0,00 Address Viale maria bakunin 12 80125 Napoli See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Sud Campania Napoli Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MICRONIT HOLDING BV Participation ended Netherlands Net EU contribution € 0,00 Address Colosseum 15 7521 PV Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 AENEAM ADVANCED MEMBRANE TECHNOLOGIES Spain Net EU contribution € 250 904,88 Address Calle cafe florian 14 esc 2 6c 50021 Zaragoza See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noreste Aragón Zaragoza Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HENKEL KGaA Germany Net EU contribution € 252 788,40 Address Henkelstrasse 67 40191 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Spain Net EU contribution € 250 904,88 Address Paseo miramon 182, parque tecnologico de san sebastian edificio empresarial c 20009 San sebastian See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 MICRONIT BV Netherlands Net EU contribution € 0,00 Address Colosseum 15 7521 PV Enschede See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Oost-Nederland Overijssel Twente Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
