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CORDIS

Artificial Molecular Machines

Deliverables

Measurement of energy storage in a motor-liquid crystal material

ESR13 will design novel responsive materials for nanoscale energy storage and measure their energy storage capacity.

Steady-state characterisation of motor-doped liposomes

ESR10 will characterize by steady-state measurements the behavior of synthetic molecular machines embedded in liposomes.

ArtMoMa newsletter

The EPM will be responsible of ArtMoMa newletters. The newletter is planned quarterly.

Synthesis of coupled biomolecular motor system

ESR9 will synthesize microtubulebased transport systems where several motors collectively transport a cargo

Contractile oscillating waves characterised by dynamic mechanical analysis

ESR8 will demonstrate the oscillating behavior of materials based on molecular motors using dynamic mechanical analys

Attendance to public events

The partners are expected to attend to public events events listed in the DoAsection 241 The consortium expects to attend one day annually

Hybridisation of artificial motors to DNA molecules

ESR5 will synthesize hybrid DNA structures functionalized with artificial molecular motors

Fast unidirectional circumrotation with chemical fuel

ESR2 will synthesize advanced artificial autonomous nanomotors fuelled with chemical energy.

Characterisation of oriented motion in solution

ESR3 will demonstrate that molecular propellers can achieve autonomous and directional motion along a trajectory on a surface under ambient conditions.

Transport of vesicles with pumping modules on microtubules

ESR14 will couple small unilamellar vesicles with incorporated pumping modules on microtubules and study their transport properties.

Synthesis of a self-healing material containing translocating motors

ESR12 will couple translocating molecular motors with polymers in order to reach new self-healing materials.

Polymeric motor gel at high wavelength actuation

ESR7 will produce a polymeric motor gel material that can be actuated using for instance visible light as external stimulus

Pumping of several macrocycles on an axle with light

ESR6 will develop molecular motors that can operate autonomously out-of-equilibrium to concentrate a molecule by dissipating light energy.

Substantial conference participations/publications

Each ESR will be requested to attend and make a presentation (oral or poster) in international conference. We anticipate that each ESR will achieve at least 3 peer-reviewed scientific publications as a main author in top-level journals such as Nature, Science, Nature Nanotech., Nature Chem., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mat.

Optically powered self-propeller synthesis

ESR4 will produce a DNA origami nanostructure functionalised with optically driven rotors in order to achieve large-scale motion.

Synthesis of mechanically active polyurethanes

ESR15 will synthesize polyurethanes containing [c2]daisy chain rotaxanes.

Multistep synthesis of a multitask programmable robot

ESR1 will show that several precise synthetic tasks can be achieved through programing of synthetic molecular machines.

Synthesis of dynamic covalent motors at surface

ESR11 will show that dynamic covalent motors can be efficiently attached at surfaces

Review on integrated molecular machines

Beneficiaries from WP2 will aim at publishing one review article in a topical issue related to their WP topic.

Overview paper in Scientific American

"An overview paper related to the ArtMoMa project will be published in a popular science magazine such as ""Scientific American"" in order to stimulate the creativity and curiosity of a broad and diverse audience (in collaboration with the partner organization Nature Nanotechnology)."

ESRs recruitment completed

Document listing the ESRs recruted and the contrat periods

Review on applications of molecular machines

Beneficiaries from WP3 will aim at publishing one review article in a topical issue related to their WP topic.

Textbook submitted for publication

"A short textbook entitled ""A Student's Guide to understand Molecular Machines and Emerging Applications"" and providing information on general state-of-the-art concepts and experimental aspects on molecular machines will be submitted for publication."

Review on nanorobots

Beneficiaries from WP1 will aim at publishing one review article in a topical issue related to their WP topic.

Data management plan

ArtMoMa project will contribute to the Open Research Data Pilot aiming at making research data findable accessible interoperable and reusable The consortium will draft a Data Management Plan It will outline ArtMoMa data management policy in compliance with H2020 guidelines The Plan will also comply with by the Consortium Agreement provisions in order to protect IP generated by the project The Plan issued at Month 6 will be updated during the project M24 and 47 to cover changes and new data

Detailed plan for ISS, IW and conference sessions

A detailed agenda of the different ISS IW and conference sessions planned during the project will be made available online

Open-access video on molecular machines

An open-access video will be created by the company Storyrunner (Scientific documentaries maker) during the 1st ArtMoMa International Workshop.

Project flyer

For communication events, partners will use flyers to communicate at the largest level for the targeted non-specialist audiences (Night of Science, Open lab Day, Fête de la Science etc. the first draft will be presented at month 2 and yearly updated . A copy of the flyer will be downloaded.

Project website and embedded social media streams

First version of the ArtMoMa Project website. The website will be regularly updated, sharing main activities and outcomes of the project. A presentation of each ESR and their project will be made, thus enhancing their visibility to the scientific community and to specific companies. A specific section will be dedicated to a non-scientific audience, and presentations for large audiences will be uploaded. Each Partner will insert on its own website a link to ArtMoMa website to entice academics or industry workers to learn more about the project.

Publications

From Molecular Machines to Stimuli-Responsive Materials

Author(s): Emilie Moulin, Lara Faour, Christian C. Carmona-Vargas, Nicolas Giuseppone
Published in: Advanced Materials, Issue Volume 32, Issue 20, 2020, Page(s) 1906036, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201906036

Switched“On” Transient Fluorescence Output from a Pulsed-Fuel Molecular Ratchet

Author(s): Andrei S. Baluna, Marcel Dommaschk, Burkhard Groh, Salma Kassem, David A. Leigh, Daniel J. Tetlow, Dean Thomas and Loli Varela López
Published in: Journal of the American Chemical Society, Issue Volume 145, issue 49, 2023, Page(s) 26519-27166, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c11290

Compact Rotaxane Superbases

Author(s): Martin J. Power, David T. J. Morris, Iñigo J. Vitorica-Yrezabal, David A. Leigh
Published in: Journal of the American Chemical Society, Issue Volume 154, Issue 15, 2023, Page(s) 8593-8599, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c01202

Design of Collective Motions from Synthetic Molecular Switches, Rotors, and Motors

Author(s): Dattler, Damien; Fuks, Gad; Heiser, Joakim; Moulin, Emilie; Perrot, Alexis; Yao, Xuyang; Giuseppone, Nicolas
Published in: Chemical Reviews, Issue Volume 120, Issue 1, 2020, Page(s) 310-433, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.9b00288

Extraction of mechanical work from stimuli-responsive molecular systems and materials

Author(s): Alexis Perrot; Emilie Moulin; Nicolas Giuseppone
Published in: Trends in Chemistry, Issue Volume 3, Issue 11, November 2021, 2021, Page(s) Pages 926-942
Publisher: Elsevier B.V
DOI: 10.1016/j.trechm.2021.08.007

Molecular Motors’ Magic Methyl and Its Pivotal Influence on Rotation

Author(s): Yohan Gisbert, Maximilian Fellert, Charlotte N. Stindt, Alexander Gerstner, and Ben L. Feringa
Published in: Journal of the American Chemical Society, Issue 2024, 2024, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c01628

Acidochromism of donor–acceptor Stenhouse adducts in organic solvent

Author(s): Antonio Fiorentino, Brian Sachini, Stefano Corra, Alberto Credi, Cristina Femoni, Aurore Fraix, Serena Silvi
Published in: Chemical Communications, Issue Volume 58, 2022, Page(s) 11236-11239, ISSN 1364-548X
Publisher: The Royal Society of Chemistry
DOI: 10.1039/d2cc03761k

Out-of-Equilibrium Mechanical Disruption of β-Amyloid-Like Fibers using Light-Driven Molecular Motors

Author(s): Dania Daou, Yohan Zarate, Mounir Maaloum, Dominique Collin, Guillaume Fleith, Doru Constantin, Emilie Moulin, Nicolas Giuseppone
Published in: Advanced Materials, Issue 2024, 2024, Page(s) 2311293, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202311293

Controlling molecular shuttling in a rotaxane with weak ring recognition sites

Author(s): Nina Bukhtiiarova, Alberto Credi, Stefano Corra
Published in: Chemical Communications, Issue Volume 59, 2023, Page(s) 13159-13162, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cc04483a

Daisy chain architectures: from discrete molecular entities to polymer materials

Author(s): Emilie Moulin, Christian C. Carmona-Vargas,Nicolas Giuseppone
Published in: Chemical Society Reviews, Issue Volume 52, 2023, Page(s) 7333-7358, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cs00619k

Comparison of actin- and microtubule-based motility systems for application in functional nanodevices

Author(s): Reuther Cordula; Catalano Rachele; Salhotra Aseem; VemulaVenukumar; Korten Till; Diez Stefan; Månsson Alf
Published in: New Journal of Physics, Issue Volume 23, Issue 7, id.075007, 35 pp., 2021, Page(s) 1-35, ISSN 1367-2630
Publisher: Institute of Physics Publishing
DOI: 10.1088/1367-2630/ac10ce

Out‐of‐Equilibrium (Supra)molecular Systems and Materials

Author(s): Prof. Nicolas Giuseppone, Prof. J.-M. Lehn, Prof. B. L. Feringa, and Prof. A. Credi
Published in: 2021, ISBN 9783527821990
Publisher: WILEY‐VCH GmbH
DOI: 10.1002/9783527821990

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