Erythrocytes properties and viability in dependence of flow and extra-cellular environment

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Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications

Author(s): Recktenwald SM, Lopes MGM, Peter S, Hof S, Simionato G, Peikert K, Hermann A, Danek A, van Bentum K, Eichler H, Wagner C, Quint S, Kaestner L.
Published in: Frontiers in Physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.884690

Imaging erythrocyte sedimentation in whole blood

Author(s): Darras, J., Breunig, H.G., John, T., Zhao, R., Koch, J., Kummerow, C., König, K., Wagner, C., Kaestner, L.
Published in: Frontiert in Physiology, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.729191

Missense mutations in <i>PIEZO1,</i> which encodes the Piezo1 mechanosensor protein, define Er red blood cell antigens

Author(s): Vanja Karamatic Crew; Louise A. Tilley; Timothy J. Satchwell; Samah A. AlSubhi; Benjamin Jones; Frances A. Spring; Piers J. Walser; Catarina Martins Freire; Nicoletta Murciano; Maria Giustina Rotordam; Svenja J. Woestmann; Marwa Hamed; Reem Alradwan; Mouza AlKhrousey; Ian Skidmore; Sarah Lewis; Shimon Hussain; Jane Jackson; Tom Latham; Mark D. Kilby; William Lester; Nadine Becker; Markus Rapedius;
Published in: Blood, Issue 19, 2022, Page(s) 135–146, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2022016504

Lingering Dynamics in Microvascular Blood Flow

Author(s): Alexander Kihm; Stephan Quint; Matthias W. Laschke; Michael D. Menger; Thomas John; Lars Kaestner; Christian Wagner; Christian Wagner
Published in: Biophys Journal, Issue 6, 2021, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1016/j.bpj.2020.12.012

Rare Anemias: Are Their Names Just Smoke and Mirrors?

Author(s): Simionato G, van Wijk R, Quint S, Wagner C, Bianchi P and Kaestner L
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.690604

Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1

Author(s): Nadine R. King, Catarina Martins Freire, Jawida Touhami, Marc Sitbon, Ashley M. Toye, Timothy J. Satchwell
Published in: PLOS Phatogens, 2024, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1011989

The Transient Receptor Potential Vanilloid Type 2 (TRPV2) Channel-A New Druggable Ca 2+ Pathway in Red Cells, Implications for Red Cell Ion Homeostasis

Author(s): Stéphane Egée, Lars Kaestner
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.677573

Continuous Percoll Gradient Centrifugation of Erythrocytes—Explanation of Cellular Bands and Compromised Age Separation

Author(s): Greta Simionato, Antonia Rabe, Joan Sebastián Gallego-Murillo, Carmen van der Zwaan,Arie Johan Hoogendijk, Maartje van den Biggelaar,Giampaolo Minetti, Anna Bogdanova Heimo Mairbäurl, Christian Wagner, Lars Kaestner, and Emile van den Akker
Published in: Cells, 2022, Page(s) 1296, ISSN 2073-4409
Publisher: Basel MDP
DOI: 10.3390/cells11081296

Genetic polymorphisms and expression of Rhesus blood group RHCE are associated with 2,3-bisphosphoglycerate in humans at high altitude

Author(s): D’Alessandro, Angelo; Earley, Eric J; Nemkov, Travis; Stephenson, Daniel; Dzieciatkowska, Monika; Hansen, Kirk C; Minetti, Giampaolo; Champigneulle, Benoit; Stauffer, Emeric; Pichon, Aurélien; Furian, Michael; Verges, Samuel; Kleinman, Steven; Norris, Philip J; Busch, Michael P; Page, Grier P; Kaestner, Lars
Published in: Proceedings of the National Academy of Sciences of USA, vol 121, iss 1, Issue 8, 2024, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2315930120

Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells

Author(s): Aline Hatem, Sofia Esperti, Nicoletta Murciano, Min Qiao, Maria Giustina Rotordam, Nadine Becker, Elie Nader, Felix Maurer, Laurent Pérès, Guillaume Bouyer, Lars Kaestner, Philippe Connes, Stéphane Egée
Published in: American Journal of Hematology, 2023, ISSN 0361-8609
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ajh.27109

Heterogeneity of red blood cells: causes and consequences

Author(s): Bogdanova, A., Kaestner, L., Simionato, G., Wickrema, A., Makhro, A.
Published in: Frontiers in Physiology, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00392

Simple Assessment of Red Blood Cell Deformability Using Blood Pressure in Capillary Channels for Effective Detection of Subpopulations in Red Blood Cells

Author(s): Yang Jun Kang, Sami Serhrouchni, Asya Makhro, Anna Bogdanova, Sung Sik Lee
Published in: ACS Omega, 2022, Page(s) 38576-38588, ISSN 2470-1343
Publisher: ACS Publications
DOI: 10.1021/acsomega.2c04027

A comparative study of two routinely used protocols for ex vivo erythroid differentiation

Author(s): Auria Godard, Robert Seute, Alexandra Grimaldi, Thomas Granier, Jacques Chiaroni, Wassim El Nemer, Maria De Grandis
Published in: Blood Cells Molecules and Diseases, 2024, ISSN 1079-9796
Publisher: Academic Press
DOI: 10.1016/j.bcmd.2024.102829

Does G6PD deficiency cause further damage to red blood cells of patients with sickle cell anaemia?

Author(s): Sofia Esperti, Camille Boisson, Mélanie Robert, Elie Nader, Agnes Cibiel, Céline Renoux, Françoise Horrand, Alexandra Gauthier, Solène Poutrel, Philippe Joly, Philippe Connes
Published in: British journal of haematology, 2022, Page(s) 289 - 291, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.18417

Red blood cell phenotyping from 3D confocal images using artificial neural networks.

Author(s): Greta Simionato; Konrad Hinkelmann; Revaz Chachanidze; Revaz Chachanidze; Paola Bianchi; Elisa Fermo; Richard van Wijk; Marc Leonetti; Christian Wagner; Christian Wagner; Lars Kaestner; Stephan Quint
Published in: PLoS Computational Biology, Issue 1, 2021, ISSN 1553-734X
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1008934

Increased retention of functional mitochondria in mature sickle red blood cells is associated with increased sickling tendency, hemolysis and oxidative stress

Author(s): Sofia Esperti , Elie Nader , Antoine Stier , Camille Boisson , Romain Carin 2, Muriel Marano , Mélanie Robert , Marie Martin, Françoise Horand 6, Agnes Cibiel, Céline Renoux, Robin Van Bruggen , Colin Blans, Yesim Dargaud, Philippe Joly, Alexandra Gauthier, Solène Poutrel, Marc Romana, Damien Roussel, Philippe Connes
Published in: British Journal of Hematology, 2023, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.3324/haematol.2023.282684

Mitochondria retention in mature RBCs from haemoglobin SC patients

Author(s): Sofia Esperti, Elie Nader, Camille Boisson, Romain Carin, Françoise Horrand, Diana Piedrahita, Céline Renoux, Philippe Joly, Alexandra Gauthier, Solène Poutrel, Philippe Connes.
Published in: British Journal of Hermatology, 2023, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.18935

Evidence of in vivo exogen protein uptake by red blood cells -a putative therapeutic concept

Author(s): Hertz, L., Flormann, D., Birnbaumer, L., Wagner, C., Laschke, M.W., Kaestner, L.
Published in: Blood Advances, 2023, ISSN 2473-9529
Publisher: ASH PUBLICATIONS
DOI: 10.1182/bloodadvances.2022008404

Space anemia unexplained: Red blood cells seem to be space-proof

Author(s): Anna Yu Bogdanova, Heimo Mairbäurl, Lars Kaestner
Published in: American Journal of Hemathology, 2022, ISSN 0361-8609
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26663

In Vitro Erythropoiesis at Different pO2 Induces Adaptations That Are Independent of Prior Systemic Exposure to Hypoxia

Author(s): Greta Simionato, Antonia Rabe, Joan Sebastián Gallego-Murillo, Carmen van der Zwaan,Arie Johan Hoogendijk, Maartje van den Biggelaar,Giampaolo Minetti, Anna Bogdanova Heimo Mairbäurl, Christian Wagner, Lars Kaestner, and Emile van den Akker
Published in: Cells, 2022, Page(s) 1082, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11071082

Dual action of Dooku1 on PIEZO1 channel in human red blood cells

Author(s): Aline Hatem , Gwendal Poussereau, Martin Gachenot, Laurent Pérès, Guillaume Bouyer, Stéphane Egée
Published in: Frontiers in Physiology, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1222983

Hemoglobin is an oxygen-dependent glutathione buffer adapting the intracellular reduced glutathione levels to oxygen availability

Author(s): Simone Fenk, Elizaveta V. Melnikova, Anastasia A. Anashkina, Yuri M. Poluektov, Pavel I. Zaripov, Vladimir A. Mitkevich , Yaroslav, V. Tkachev, Lars Kaestner, Giampaolo Minetti, Heimo Mairbäurl, Jeroen S. Goede, Alexander A. Makarov, Irina Yu Petrushanko, Anna Bogdanova
Published in: Redox Biology, 2022, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2022.102535

Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer

Author(s): Daniel Flormann; Min Qiao; Nicoletta Murciano; Giulia Iacono; Alexis Darras; Sebastian Hof; Steffen M. Recktenwald; Maria Giustina Rotordam; Nadine Becker; Jürgen Geisel; Christian Wagner; Marieke von Lindern; Emile van den Akker; Lars Kaestner
Published in: American journal of hematology, Issue 15, 2022, ISSN 0361-8609
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/ajh.26509

Effect of Cell Age and Membrane Rigidity on Red Blood Cell Shape in Capillary Flow

Author(s): Mohammed Nouaman; Alexis Darras; Thomas John; Greta Simionato; Minke A. E. Rab; Richard van Wijk; Matthias W. Laschke; Lars Kaestner; Christian Wagner; Steffen M. Recktenwald
Published in: Cells; Volume 12; Issue 11; Pages: 1529, Issue 6, 2023, ISSN 2073-4409
Publisher: Basel MDPI AG
DOI: 10.3390/cells12111529

Machine learning microfluidic based platform: Integration of Lab-on-Chip devices and data analysis algorithms for red blood cell plasticity evaluation in Pyruvate Kinase Disease monitoring

Author(s): Mencattini, A.; Rizzuto, V.; Antonelli, G.; Di Giuseppe, D.; D’Orazio,M.; Filippi, J.; Comes, M.C.; Casti, P.; Vives Corrons, J.L.; Garcia-Bravo, M.; Segovia, J.C.; Mañú-Pereira, M.M.; Lopez-Martinez, M.J.; Samitier, J.; Martinelli, E
Published in: Sensors and Actuators A: Physical, 2023, ISSN 0924-4247
Publisher: Elsevier BV
DOI: 10.1016/j.sna.2023.114187

Hemoglobin as oxygen-dependent glutathione buffer

Author(s): Simone Fenk; Elizaveta V. Melnikova; Anastasia A. Anashkina; Yuri M. Poluektov; Pavel I. Zaripov; Vladimir A. Mitkevich; Lars Kaestner; Giampaolo Minetti; Heimo Mairbäurl; Jeroen S. Goede; Alexander A Makarov; Irina Yu. Petrushanko; Anna Bogdanova
Published in: Redox Biology, Issue 16, 2022, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.5281/zenodo.5835937

Big Data in Transfusion Medicine and Artificial Intelligence Analysis for Red Blood Cell Quality Control

Author(s): Lopes MGM, Recktenwald SM, Simionato G, Eichler H, Wagner C, Quint S, Kaestner L.
Published in: Transfusion Medicine and Hemotherapy, 2023, ISSN 1660-3796
Publisher: S. Karger AG
DOI: 10.1159/000530458

Cell-free Layer Development and Spatial Organization of Healthy and Rigid Red Blood Cells in a Microfluidic Bifurcation

Author(s): Y. Rashidi, O. Aouane, A. Darras, T. John, J. Harting, C. Wagner, S. M. Recktenwald
Published in: Soft Matter, 2023, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sm00517h

Artificial intelligence: Training the trainer

Author(s): Lars Kaestner
Published in: Crossref, Issue 8, 2022, ISSN 0007-1048
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/bjh.18358

The Chloride Conductance Inhibitor NS3623 Enhances the Activity of a Non-selective Cation Channel in Hyperpolarizing Conditions

Author(s): David Monedero Alonso , Laurent Pérès , Aline Hatem, Guillaume Bouyer , Stéphane Egée
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.743094

Red blood cell lingering modulates hematocrit distribution in the microcirculation

Author(s): Yazdan Rashidi; Greta Simionato; Qi Zhou; Thomas John; Alexander Kihm; Mohammed Bendaoud; Timm Krüger; Miguel O. Bernabeu; Lars Kaestner; Matthias W. Laschke; Michael D. Menger; Christian Wagner; Alexis Darras
Published in: Rashidi , Y , Simionato , G , Zhou , Q , John , T , Kihm , A , Bendaoud , M , Krüger , T , Bernabeu , M O , Kaestner , L , Laschke , M W , Menger , M D , Wagner , C & Darras , A 2023 , ' Red blood cell lingering modulates hematocrit distribution in the microcirculation ' , Biophysical Journal , vol. 122 , no. 8 , pp. 1526-1537 . https://doi.org/10.1016/j.bpj.2023.03.020, Issue 18, 2023, ISSN 0006-3495
Publisher: Biophysical Society
DOI: 10.1101/2022.08.16.504126

BNIP3L/NIX regulates both mitophagy and pexophagy.

Author(s): Wilhelm LP, Zapata-Muñoz J, Villarejo-Zori B, Pellegrin S, Freire CM, Toye AM, Boya P, Ganley IG
Published in: The EMBO Journal, 2022, ISSN 0261-4189
Publisher: Nature Publishing Group
DOI: 10.15252/embj.2022111115

Artificial Intelligence Meets Hematology

Author(s): Kaestner, L.
Published in: Transfusion and Apheresis Science, 2020, ISSN 1473-0502
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.transci.2020.102986

Trends in the Development of Diagnostic Tools for Red Blood Cell-Related Diseases and Anemias

Author(s): Kaestner L and Bianchi P
Published in: Frontiers in Physiology, 2020, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00387

Erythrocyte sedimentation: Effect of aggregation energy on gel structure during collapse

Author(s): Anil Kumar Dasanna; Alexis Darras; Thomas John; Gerhard Gompper; Lars Kaestner; Christian Wagner; Dmitry A. Fedosov
Published in: Physical review / E 105(2), 024610 (2022). doi:10.1103/PhysRevE.105.024610, Issue 3, 2022, ISSN 1095-3787
Publisher: APS
DOI: 10.1103/physreve.105.024610

Neocytolysis after return from high altitude (5100 m): Further evidence for absentia

Author(s): Kaestner, L., Champigneulle, B., Stauffer, E., Furian, M., De Abreu, J. John, T., Nader, E., Scheller, A., Pichon, A., Connes, P., Robach, P., 1Brugniaux, J.V., Borsch, C., Rudloff, S., Mairbäurl, Verges, S.
Published in: Acta Physiologica, 2023, ISSN 1748-1708
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/apha.14002

The Erythrocyte Sedimentation Rate and Its Relation to Cell Shape and Rigidity of Red Blood Cells from Chorea-Acanthocytosis Patients in an Off-Label Treatment with Dasatinib.

Author(s): Antonia Rabe; Alexander Kihm; Alexis Darras; Kevin Peikert; Greta Simionato; Anil K. Dasanna; Hannes Glaß; Jürgen Geisel; Stephan Quint; Adrian Danek; Christian Wagner; Christian Wagner; Dmitry A. Fedosov; Andreas Hermann; Lars Kaestner
Published in: Volume 11, Issue 1, 2021, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11050727

The Gárdos channel and Piezo1 revisited: Comparison between reticulocytes and mature red blood cells

Author(s): Petkova-Kirova, P., Murciano, N., Iacono, G., Jansen, J., Simionato, G., Qiao, M., van der Zwaan, C., Rotordam, G.M., John, T., Hertz, L., Hoogendijk, A.J., Becker, N., Wagner, C., von Lindern, M., Egee, S., van den Akker, E., Lars Kaestner, L.
Published in: International Journal of Molecular Sciences, 2024, ISSN 1661-6596
Publisher: MDPI
DOI: 10.3390/ijms25031416

Acanthocyte Sedimentation Rate as a Diagnostic Biomarker for Neuroacanthocytosis Syndromes: Experimental Evidence and Physical Justification.

Author(s): Alexis Darras; Kevin Peikert; Antonia Rabe; François Yaya; Greta Simionato; Thomas John; Anil K. Dasanna; Semen Buvalyy; Jürgen Geisel; Andreas Hermann; Dmitry A. Fedosov; Adrian Danek; Christian Wagner; Christian Wagner; Lars Kaestner
Published in: Cells, Vol 10, Iss 788, p 788 (2021), Issue 2, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.22028/d291-33926

Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients.

Author(s): Jue Wang; Laura Hertz; Sandra Ruppenthal; Wassim El Nemer; Philippe Connes; Jeroen S. Goede; Anna Bogdanova; Lutz Birnbaumer; Lutz Birnbaumer; Lars Kaestner
Published in: Volume 10, Issue 3, 2021, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells10020456

Gardos channelopathy: functional analysis of a novel KCNN4 variant

Author(s): Elisa Fermo, David Monedero-Alonso, Polina Petkova-Kirova, Asya Makhro, Laurent Pérès, Guillaume Bouyer, Anna Paola Marcello, Filomena Longo, Giovanna Graziadei, Wilma Barcellini, Anna Bogdanova, Stephane Egee, Lars Kaestner, Paola Bianchi
Published in: Blood advances, 2021, ISSN 2473-9537
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2020003285

Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

Author(s): Steffen M Recktenwald, Greta Simionato, Marcelle GM Lopes, Fabia Gamboni, Monika Dzieciatkowska, Patrick Meybohm, Kai Zacharowski, Andreas von Knethen, Christian Wagner, Lars Kaestner, Angelo D'Alessandro, Stephan Quint
Published in: eLife Sciences Publications, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.81316

Donor Age and Red Cell Age Contribute to the Variance in Lorrca Indices in Healthy Donors for Next Generation Ektacytometry: A Pilot Study.

Author(s): van Cromvoirt AM, Fenk S, Sadafi A, Melnikova EV, Lagutkin DA, Dey K, Petrushanko IY, Hegemann I, Goede JS, Bogdanova A.
Published in: Frontiers in Physiology, 2021, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.639722

Early stage of erythrocyte sedimentation rate test: Fracture of a high-volume-fraction gel

Author(s): Thomas John; Lars Kaestner; Christian Wagner; Alexis Darras
Published in: Crossref, Issue 2, 2023, ISSN 2752-6542
Publisher: Oxford University Press on behalf of the National Academy of Sciences
DOI: 10.1093/pnasnexus/pgad416

The putative role of the Transient Receptor Potential ion channel of Vanilloid type 2 (TRPV2) in red blood cell storage lesions

Author(s): Murciano, N., Kaestner, L.
Published in: Transfusion Medicine and Hemotherapy, 2023, ISSN 1660-3796
Publisher: S. Karger AG
DOI: 10.1159/000531282

Versatile Vessel-on-a-Chip Platform for Studying Key Features of Blood Vascular Tumors

Author(s): Marina Llenas, Roberto Paoli, Natalia Feiner-Gracia, Lorenzo Albertazzi, Josep Samitier, David Caballero
Published in: Bioengineering, 2021, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/bioengineering8060081

Combining microfluidics with machine learning algorithms for RBC classification in rare hereditary hemolytic anemia

Author(s): Valeria Rizzuto, Arianna Mencattini, Begoña Álvarez‑González, Davide Di Giuseppe, Eugenio Martinelli, David Beneitez‑Pastor, Maria del Mar Mañú‑Pereira, Maria José
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-92747-2

Mechanistic ion channel interactions in red cells of patients with Gardos channelopathy

Author(s): Julia Jansen, Min Qiao, Laura Hertz, Xijia Wang, Elisa Fermo, Anna Zaninoni, Raffaella Colombatti, Ingolf Bernhardt, Paola Bianchi, Lars Kaestner
Published in: Blood advances, 2021, ISSN 2473-9537
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2020003823

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