SuperCol: Rational design of super-selective and responsive colloidal particles for biomedical applications

Project Information

SuperCol

Grant agreement ID: 860914

DOI

10.3030/860914

Project closed

EC signature date 11 September 2019

Start date 1 January 2020

End date 31 December 2023

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 4 058 814,96

EU contribution

€ 4 058 814,96

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Overall recruitment report

Websites, patent fillings, videos etc. (1)

website

First version of external SUPERCOL website online

Other (4)

Awarding of doctoral degrees

Awarding of doctoral degrees, all beneficiaries are in lead and provide the degree at their respective University

Call for applications
Software to correct mislocalisation

Software to correct mislocalisation based on optical parameters and particle geometry

Supervisory board of the network

Supervisory board instated and added to website

Publications

Peer reviewed articles (32)

Correlative imaging for polymer science

Author(s): Yuyang Wang, Heiner Friedrich, Ilja K. Voets, Peter Zijlstra, Lorenzo Albertazzi
Published in: Journal of Polymer Science, Issue 59, 2023, Page(s) 1232-1240, ISSN 2642-4150
Publisher: Wiley
DOI: 10.1002/pol.20210013

Pathways and challenges towards a complete characterization of microgels.

Author(s): Frank Scheffold
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17774-5

Electrochemical Determination of Gallic Acid in Tea Samples Using Pyramidal Pt Nanoparticles

Author(s): Tiziano Di Giulio, Maria Antonieta Ramírez‐Morales, Valentina Mastronardi, Giuseppe Mele, Rosaria Brescia, Pier Paolo Pompa, Cosimino Malitesta, Giuseppe Egidio De Benedetto, Mauro Moglianetti, Maria Ada Malvindi, Elisabetta Mazzotta
Published in: Advanced Electronic Materials, Issue 11, 2025, ISSN 2199-160X
Publisher: Wiley
DOI: 10.1002/aelm.202400792

Protein aggregation monitoring in cells under oxidative stress: a novel fluorescent probe based on a 7-azaindole-BODIPY derivative

Author(s): Diego Herrera-Ochoa, Iván Llano, Consuelo Ripoll, Pierre Cybulski, Martin Kreuzer, Susana Rocha, Eva M. García-Frutos, Iván Bravo, Andrés Garzón-Ruiz
Published in: Journal of Materials Chemistry B, Issue 12, 2025, Page(s) 7577-7590, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4tb00567h

Comparing the Structure of Microgels at Liquid–Liquid and Solid–Liquid Interfaces

Author(s): Rodrigo Rivas-Barbosa, Fabrizio Camerin, Jacopo Vialetto, Shivaprakash N. Ramakrishna, Lucio Isa, Emanuela Zaccarelli
Published in: Langmuir, Issue 41, 2025, Page(s) 16674-16684, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.5c02599

IgG and IgM differentiation in a particle-based agglutination assay by control over antigen surface density

Author(s): Shanil Gandhi, Xhorxhina Shaulli, Jeppe Fock, Frank Scheffold, Rodolphe Marie
Published in: APL Bioengineering, Issue 8, 2024, ISSN 2473-2877
Publisher: American Physical Society
DOI: 10.1063/5.0196224

Point-Spread Function Deformations Unlock 3D Localization Microscopy on Spherical Nanoparticles

Author(s): Teun A.P.M. Huijben, Sarojini Mahajan, Masih Fahim, Peter Zijlstra, Rodolphe Marie, Kim I. Mortensen
Published in: ACS Nano, Issue 18, 2025, Page(s) 29832-29845, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c09719

Ion and Molecular Sieving With Ultrathin Polydopamine Nanomembranes

Author(s): Jiyao Yu, Tommaso Marchesi D'Alvise, Iain Harley, Adam Krysztofik, Ingo Lieberwirth, Przemyslaw Pula, Pawel W. Majewski, Bartlomiej Graczykowski, Johannes Hunger, Katharina Landfester, Seah Ling Kuan, Rachel Shi, Christopher V. Synatschke, Tanja Weil
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202401137

DNA Self-Assembly of Single Molecules with Deterministic Position and Orientation

Author(s): Aleksandra K. Adamczyk, Teun A. P. M. Huijben, Miguel Sison, Andrea Di Luca, Germán Chiarelli, Stefano Vanni, Sophie Brasselet, Kim I. Mortensen, Fernando D. Stefani, Mauricio Pilo-Pais, and Guillermo P. Acuna
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c06936

Rate-Engineered Plasmon-Enhanced Fluorescence for Real-Time Microsecond Dynamics of Single Biomolecules

Author(s): Sjoerd W. Nooteboom, Kasper R. Okholm, Vincenzo Lamberti, Bas Oomen, Duncan S. Sutherland, Peter Zijlstra
Published in: Nano Letters, Issue 24, 2024, Page(s) 11641-11647, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.4c03220

Supramolecular assembly guided by photolytic redox cycling

Author(s): Patrick Roth, Raphael Meyer, Iain Harley, Katharina Landfester, Ingo Lieberwirth, Manfred Wagner, David Y. W. Ng, Tanja Weil
Published in: Nature Synthesis, Issue 2, 2023, Page(s) 980-988, ISSN 2731-0582
Publisher: Springer Nature
DOI: 10.1038/s44160-023-00343-1

Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature‐Responsive Polymer

Author(s): Marina de Souza Melchiors, Tsvetomir Ivanov, Iain Harley, Claudia Sayer, Pedro H. H. Araújo, Lucas Caire da Silva, Calum T. J. Ferguson, Katharina Landfester
Published in: Angewandte Chemie International Edition, Issue 61, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202207998

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced Fluorescence

Author(s): Kasper R. Okholm, Sjoerd W. Nooteboom, Johan Nygaard Vinther, Vincenzo Lamberti, Swayandipta Dey, Ebbe Sloth Andersen, Peter Zijlstra, Duncan S. Sutherland
Published in: ACS Nano, Issue 18, 2025, Page(s) 35429-35442, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c12600

Polymer Nano‐Carrier‐Mediated Gene Delivery: Visualizing and Quantifying DNA Encapsulation Using dSTORM

Author(s): Xhorxhina Shaulli, Aura Maria Moreno‐Echeverri, Mariza Andoni, Eileen Waeber, Shivaprakash N. Ramakrishna, Cornelia Fritsch, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Frank Scheffold
Published in: Small, Issue 21, 2025, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202405929

Probing Temperature Responsivity of Microgels and Its Interplay with a Solid Surface by Super-Resolution Microscopy and Numerical Simulations.

Author(s): Xhorxhina Shaulli, Rodrigo Rivas-Barbosa, Maxime J. Bergman, Chi Zhang, Nicoletta Gnan, Frank Scheffold, and Emanuela Zaccarelli
Published in: ACS Nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c07569

Link between morphology, structure and interactions of composite microgels

Author(s): Rodrigo Rivas-Barbosa, José Ruiz-Franco, Mayra A. Lara-Peña, Jacopo Cardellini, Angel Licea-Claverie, Fabrizio Camerin, Emanuela Zaccarelli, Marco Laurati
Published in: Macromolecules, 2021, ISSN 0024-9297
Publisher: American Chemical Society
DOI: 10.1021/acs.macromol.1c02171

Tailoring reactive handles on the surface of nanoparticles for covalent conjugation of biomolecules

Author(s): Francesca Mazzotta, Sharafudheen Pottanam Chali, Ingo Lieberwirth, Calum T. J. Ferguson, Katharina Landfester
Published in: Polymer Chemistry, Issue 16, 2025, Page(s) 433-440, ISSN 1759-9954
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4py01119h

Coupling Single Molecules to DNA-Based Optical Antennas with Position and Orientation Control

Author(s): Aleksandra K. Adamczyk, Fangjia Zhu, Daniel Schäfer, Yuya Kanehira, Sergio Kogikoski, Ilko Bald, Sebastian Schlücker, Karol Kołątaj, Fernando D. Stefani, Guillermo P. Acuna
Published in: ACS Photonics, Issue 11, 2024, Page(s) 5267-5272, ISSN 2330-4022
Publisher: American Chemical Society
DOI: 10.1021/acsphotonics.4c01506

An Outer Membrane‐Inspired Polymer Coating Protects and Endows <i>Escherichia coli</i> with Novel Functionalities

Author(s): Andrea Belluati, Iain Harley, Ingo Lieberwirth, Nico Bruns
Published in: Small, Issue 19, 2023, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202303384

Practical considerations for plunge freezing samples over 40 °C for Cryo-EM

Author(s): Iain Harley, Francesca Mazzotta, Xhorxhina Shaulli, Frank Scheffold, Katharina Landfester, Ingo Lieberwirth
Published in: Micron, Issue 188, 2024, Page(s) 103745, ISSN 0968-4328
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.micron.2024.103745

Continuous Monitoring Biosensing Mediated by Single-Molecule Plasmon-Enhanced Fluorescence in Complex Matrices

Author(s): Vincenzo Lamberti, Mathias Dolci, Peter Zijlstra
Published in: ACS Nano, 2024, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c12428

Concentration and temperature dependent interactions and state diagram of dispersions of copolymer microgels

Author(s): José Ruiz-Franco, Rodrigo Rivas-Barbosa, Mayra A. Lara-Peña, José R. Villanueva-Valencia, Angel Licea-Claverie, Emanuela Zaccarelli, Marco Laurati
Published in: Soft Matter, Issue 19, 2024, Page(s) 3614-3628, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sm00120b

Dual-color core–shell silica nanosystems for advanced super-resolution biomedical imaging

Author(s): Maria Antonieta Ramirez-Morales, Elisa De Luca, Chiara Coricciati, Alberto Rainer, Giuseppe Gigli, Giuseppe Mele, Pier Paolo Pompa, and Maria Ada Malvindi
Published in: Nanoscale Advances, 2023, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3na00310h

Single-shot Stokes polarimetry of plasmon-coupled single-molecule fluorescence

Author(s): Sarojini Mahajan, Yuyang Wang, Teun A.P.M. Huijben, Rodolphe Marie, Peter Zijlstra
Published in: Nanophotonics, 2025, ISSN 2192-8606
Publisher: Walter de Gruyter GmbH
DOI: 10.1515/nanoph-2025-0352

Biomolecular interactions on densely coated nanoparticles: a single-molecule perspective

Author(s): Swayandipta Dey,Rodrigo Rivas-Barbosa,Francesco Sciortino, Emanuela Zaccarelli and Peter Zijlstra
Published in: Nanoscale, 2024, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3nr06140j

Chaperone‐Derived Copper(I)‐Binding Peptide Nanofibers Disrupt Copper Homeostasis in Cancer Cells

Author(s): M. T. Jeena, Julian Link, Jian Zhang, Iain Harley, Petri Turunen, Robert Graf, Manfred Wagner, Luis Andre Baptista, Hendrik R. A. Jonker, Liyang Cui, Ingo Lieberwirth, Katharina Landfester, Jianghong Rao, David Y. W. Ng, Tanja Weil
Published in: Angewandte Chemie International Edition, Issue 63, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202412477

Assembly of biomimetic microreactors using caged-coacervate droplets

Author(s): Arjaree Jobdeedamrong, Shoupeng Cao, Iain Harley, Daniel Crespy, Katharina Landfester, Lucas Caire da Silva
Published in: Nanoscale, Issue 15, 2024, Page(s) 2561-2566, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr05101j

Nanoparticle characterisation <i>via</i> 2D classification using single particle averaging

Author(s): Iain Harley, Anke Kaltbeitzel, Francesca Mazzotta, Kaloian Koynov, Sarah S. Lembke, Thao P. Doan-Nguyen, Katharina Landfester, Ingo Lieberwirth
Published in: Nanoscale Horizons, Issue 10, 2025, Page(s) 1642-1652, ISSN 2055-6756
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d5nh00094g

Versatile and Robust Method for Antibody Conjugation to Nanoparticles with High Targeting Efficiency

Author(s): Indra Van Zundert, Maria Bravo, Olivier Deschaume, Pierre Cybulski, Carmen Bartic, Johan Hofkens, Hiroshi Uji-i, Beatrice Fortuni, and Susana Rocha
Published in: Pharmaceutics, 2021, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13122153

Nanoparticle Accumulation and Penetration in 3D Tumor Models: the Effect of Size, Shape, and Surface Charge

Author(s): Pierre Cybulski, Maria Bravo, Jim Jui-Kai Chen, Indra Van Zundert, Sandra Krzyzowska, Farsai Taemaitree, Hiroshi Uji-i, Johan Hofkens, Susana Rocha, Beatrice Fortuni
Published in: Frontiers in Cell and Developmental Biology, 2025, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.1101/2024.12.06.626955

Gaining control on optical force by the stimulated-emission resonance effect

Author(s): Tetsuhiro Kudo, Boris Louis, Hikaru Sotome, Jui-Kai Chen, Syoji Ito, Hiroshi Miyasaka, Hiroshi Masuhara, Johan Hofkens and Roger Bresolí-Obach
Published in: Chemical Science, 2023, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc01927f

Aerobic Photobiocatalysis Enabled by Combining Core–Shell Nanophotoreactors and Native Enzymes

Author(s): Wenxin Wei, Francesca Mazzotta, Ingo Lieberwirth, Katharina Landfester, Calum T. J. Ferguson, and Kai A. I. Zhang:
Published in: Journal of the American Chemical Society, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c00576

Other (6)

Chaperone-derived Cu(I)-binding peptide nanofibers disrupt copper homeostasis in cancer cells

Author(s): Jeena M. Thekkeyil ,Julian Link ,Jian Zhang ,Luis Andre Baptista ,Hendrik R. A. Jonker ,Iain Harley ,Petri Turunen ,Liyang Cui ,Ingo Lieberwirth ,Katharina Landfester ,Robert Graf ,Manfred Wagner ,Jianghong Rao ,David Ng ,Tanja Weil
Published in: 2024
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2024-v04mz

Kinetics and dynamics of single-molecule multivalent interactions revealed by plasmon-enhanced fluorescence

Author(s): Kasper R. Okholm, Sjoerd W. Nooteboom, Vincenzo Lamberti, Swayandipta Dey, Peter Zijlstra, Duncan S. Sutherland
Published in: 2024
Publisher: bioRxiv
DOI: 10.1101/2023.12.08.570798

A Fluorescent Probe for Protein Misfolding and Aggregation Due to Oxidative Stress Based on a 7-Azaindole-BODIPY Derivative

Author(s): Diego Herrera-Ochoa ,Iván Llano ,Consuelo Ripoll ,Pierre Cybulski ,Martin Kreuzer,Susana Rocha ,Eva M. García-Frutos ,Iván Bravo ,Andrés Garzón Ruiz
Published in: 2024
Publisher: ChemRxiv
DOI: 10.26434/chemrxiv-2024-94b66

Exact particle-enhanced point-spread function unlocks 3D super-resolution localization microscopy on nanoparticles

Author(s): Teun A. P. M. Huijben, Sarojini Mahajan, Peter Zijlstra, Rodolphe Marie, Kim I. Mortensen
Published in: 2023
Publisher: Arxiv
DOI: 10.48550/arxiv.2306.08148

Towards full control of molecular exciton energy transfer via FRET in DNA origami assemblies

Author(s): Aleksandra K. Adamczyk, Teun A.P.M. Huijben, Karol Kolataj, Fangjia Zhu, Rodolphe Marie, Fernando D. Stefani, Guillermo P. Acuna
Published in: 2024
Publisher: arxiv
DOI: 10.48550/arxiv.2402.06292

Towards full control of molecular exciton energy transfer via FRET in DNA origami assemblies

Author(s): Aleksandra K. Adamczyk, Teun A.P.M. Huijben, Karol Kolataj, Fangjia Zhu, Rodolphe Marie, Fernando D. Stefani, Guillermo P. Acuna
Published in: Issue 1, 2025
Publisher: arxiv

Non-peer reviewed articles (1)

Correction to “Aerobic Photobiocatalysis Enabled by Combining Core–Shell Nanophotoreactors and Native Enzymes”

Author(s): Wenxin Wei, Francesca Mazzotta, Ingo Lieberwirth, Katharina Landfester, Calum T. J. Ferguson, Kai A. I. Zhang
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 3826-3826, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c00723