European Oocyte Biology Research Innovation Training Net

Información del proyecto

EUROVA

Identificador del acuerdo de subvención: 860960

DOI

10.3030/860960

Proyecto cerrado

Fecha de la firma de la CE 12 Agosto 2019

Fecha de inicio 1 Noviembre 2019

Fecha de finalización 31 Octubre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 970 860,88

Aportación de la UE

€ 3 970 860,88

Coordinado por

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (16)

Identification of optimum antioxidant regime for follicle survival post transplant of cryopreserved ovarian tissue

The optimum antioxidant regime for follicle survival post transplant of cryopreserved ovarian tissue will be identified.

Identification of species specific and conserved physiologically-sensitive checkpoints and processes of oocyte development.

Species specific and conserved physiologically sensitive checkpoints and processes of oocyte development will be identified.

Minutes on design and launch of EUROVA website, social media profiles, links to EUROVA website and publication of regular updates and blogs

Minutes on design and launch of EUROVA website, social media profiles, links to EUROVA website and publication of regular updates and blogs.

Multi-species digital model of oocyte growth and maturation

Development of a multispecies digital model of oocyte growth and maturation will be complete.

Report on dissemination and exploitation activities

Report on dissemination and exploitation activities for the duration of EUROVA project

Adaptation of ART protocols for effective use in endangered mammalian species

The adaptation of ART protocols for effective use in endangered mammalian species will be developed.

Refinement of ART protocols to enhance oocyte and embryo quality.

The ART protocols will be refined to enhance oocyte and embryo quality.

Comparative mechanistic and functional blueprint of the ontogeny of DNA methylation, RNA transcription and translation during mammalian oocyte growth and maturation

Comparative mechanistic and blueprint of the ontogeny of DNA methylation, RNA transcription and translation during mammalian oocyte growth and maturation will be completed.

Report on communication and public engagement activities

Report on communication and public engagement activities throughout the EUROVA project.

Identification of COC signaling molecules involved in maintenance of chromatin stability and oocyte quality (Mo 36).

COC signaling molecules involved in maintenance of chromatin stability and oocyte quality will be identified.

Knowledge of the kinetics of rhinoceros oocyte maturation, fertilization and early cleavage development and key events associated with developmental arrest

Development of the knowledge of the kinetics of rhinoceros oocyte maturation, fertilization and early cleavage development and key events associated with developmental arrest.

Animation of oocyte growth and maturation for postgraduate education and lay version for patient information

An animation of oocyte growth and maturation for postgraduate education and lay version for patient information will be developed.

Prototype artificial intelligent software for planning patient tailored fertility treatment; upload of educational animation to EUROVA website for initial trialing.

The protoype for artificial intelligence software for planning patient tailored fertility treatment will be developed and the educational animation will be uploaded to EUROVA website for initial trialing.

Multicentred/multispecies evaluation of the quality of oocytes following microfluidic IVM

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List of conserved and species-specific ART sensitive and resistant chromatin regions in oocytes

A list of conserved and species specific ART sensitive and resistant chromatin regions in oocytes will be generated.

Identification of potential rescue targets in AMA oocytes

Potential rescue targets in AMA oocytes will be identified.

Open Research Data Pilot (1)

DMP

Completion of version 1 of DMP

Publicaciones

Peer reviewed articles (26)

048 A meta-analysis suggests that the culture environment affects mRNA translation in bovine oocytes

Autores: M. Ladrón de Guevara, M.B. Rabaglino, M.A. Sirard, F. Franciosi
Publicado en: Animal - science proceedings, Edición 14, 2023, Página(s) 460, ISSN 2772-283X
Editor: Elsevier
DOI: 10.1016/j.anscip.2023.03.049

Manual versus deep learning measurements to evaluate cumulus expansion of bovine oocytes and its relationship with embryo development in vitro

Autores: Annelies Raes, Georgios Athanasiou, Nima Azari-Dolatabad, Hafez Sadeghi, Sebastian Gonzalez Andueza, Josep Lluis Arcos, Jesus Cerquides, Krishna Chaitanya Pavani, Geert Opsomer, Osvaldo Bogado Pascottini, Katrien Smits, Daniel Angel-Velez, Ann Van Soom
Publicado en: Computers in Biology and Medicine, Edición 168, 2024, Página(s) 107785, ISSN 0010-4825
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.107785

Cryopreservation of okapi (Okapia johnstoni) oocytes following in vitro maturation

Autores: Raffaella Simone, Daniel Čižmár, Susanne Holtze, Baptiste Mulot, Benjamin Lamglait, Tobias Knauf-Witzens, Annika Weigold, Robert Hermes, Thomas B. Hildebrandt
Publicado en: Theriogenology Wild, Edición 4, 2024, Página(s) 100088, ISSN 2773-093X
Editor: Theriogenology Wild
DOI: 10.1016/j.therwi.2024.100088

Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes

Autores: Styliani Galatidou, Aleksandra A Petelski, Aïda Pujol, Karinna Lattes, Lais B Latorraca, Trudee Fair, Mina Popovic, Rita Vassena, Nikolai Slavov, Montserrat Barragán
Publicado en: Molecular Human Reproduction, Edición 30, 2024, ISSN 1460-2407
Editor: OXFORD UNIVERSITY PRESS
DOI: 10.1093/molehr/gaae023

Meiotic maturation failure in primary ovarian insufficiency: insights from a bovine model

Autores: Sara Pietroforte, Pritha Dey, Elena Ibáñez, Alberto Maria Luciano, Valentina Lodde, Federica Franciosi, Mina Popovic, Rita Vassena, Filippo Zambelli
Publicado en: Journal of Assisted Reproduction and Genetics, Edición 41, 2024, Página(s) 2011-2020, ISSN 1058-0468
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10815-024-03160-3

A spotlight on factors influencing the in vitro folliculogenesis of isolated preantral follicles

Autores: Pritha Dey, Noemi Monferini, Ludovica Donadini, Valentina Lodde, Federica Franciosi, Alberto Maria Luciano
Publicado en: Journal of Assisted Reproduction and Genetics, 2024, ISSN 1058-0468
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10815-024-03277-5

Human platelet lysate improves the growth and survival of cultured human pre-antral follicles

Autores: Cristina Subiran Adrados, Jesús Cadenas, Mengxue Zheng, Sofie Lund, Elisabeth Clare Larsen, Mette Honnens Tanvig, Vinnie Hornshøj Greve, Paul Blanche, Claus Yding Andersen, Stine Gry Kristensen
Publicado en: Reproductive BioMedicine Online, Edición 47, 2023, Página(s) 103256, ISSN 1472-6483
Editor: Reproductive Healthcare Ltd
DOI: 10.1016/j.rbmo.2023.06.011

044 Gene expression profiling using next generation sequencing of primordial, primary and secondary bovine follicles

Autores: N. Monferini, P. Dey, F. Franciosi, F. Zambelli, V. Lodde, A.M. Luciano
Publicado en: Animal - science proceedings, Edición 14, 2023, Página(s) 457-458, ISSN 2772-283X
Editor: Elsevier
DOI: 10.1016/j.anscip.2023.03.045

Enhancing Medical Image Segmentation: Ground Truth Optimization through Evaluating Uncertainty in Expert Annotations

Autores: Georgios Athanasiou, Josep Lluis Arcos, Jesus Cerquides
Publicado en: Mathematics, Edición 11, 2023, Página(s) 3771, ISSN 2227-7390
Editor: MDPI
DOI: 10.3390/math11173771

A century of programmed cell death in the ovary: a commentary

Autores: Pritha Dey, Alberto Maria Luciano
Publicado en: Journal of Assisted Reproduction and Genetics, Edición 39, 2022, Página(s) 63-66, ISSN 1058-0468
Editor: Kluwer Academic/Plenum Publishers
DOI: 10.1007/s10815-021-02389-6

Umbilical cord blood–derived platelet-rich plasma: a clinically acceptable substitute for fetal bovine serum?

Autores: Cristina Subiran, Stine Gry Kristensen, Claus Yding Andersen
Publicado en: Fertility and Sterility, Edición 115, 2022, Página(s) 336-337, ISSN 0015-0282
Editor: Elsevier BV
DOI: 10.1016/j.fertnstert.2020.10.027

The ethical assessment of Assisted Reproductive Technologies (ART) in wildlife conservation

Autores: Barbara de Mori, Elena Mercugliano, Pierfrancesco Biasetti, Ilaria Pollastri, Maria Michela Spiriti, Daniela Florio, Francesco Andreucci, Frank Göritz, Susanne Holtze, Cesare Galli, Jan Stejskal, Silvia Colleoni, Giovanna Lazzari, Steven Seet, Jan Zwilling, David Ndeereh, Isaac Lekolool, Stephen Ngulu, Dominic Mijele, Daniel Čižmár, Raffaella Simone, Lisa Schrade, Simone Basile, Thomas B. Hild
Publicado en: Biological Conservation, Edición 290, 2024, Página(s) 110423, ISSN 0006-3207
Editor: Elsevier BV
DOI: 10.1016/j.biocon.2023.110423

From follicle to blastocyst: microRNA-34c from follicular fluid-derived extracellular vesicles modulates blastocyst quality

Autores: Camilla Benedetti, Krishna Chaitanya Pavani, Yannick Gansemans, Nima Azari-Dolatabad, Osvaldo Bogado Pascottini, Luc Peelman, Rani Six, Yuan Fan, Xuefeng Guan, Koen Deserranno, Andrea Fernández-Montoro, Joachim Hamacher, Filip Van Nieuwerburgh, Trudee Fair, An Hendrix, Katrien Smits, Ann Van Soom
Publicado en: Journal of Animal Science and Biotechnology, Edición 15, 2024, ISSN 2049-1891
Editor: BMC
DOI: 10.1186/s40104-024-01059-8

043 A transcriptomic approach towards the improvement of physiological systems for the in vitro culture of isolated bovine primordial follicles

Autores: P. Dey, N. Monferini, V. Lodde, F. Zambelli, F. Franciosi, A.M. Luciano
Publicado en: Animal - science proceedings, Edición 14, 2023, Página(s) 457, ISSN 2772-283X
Editor: Elsevier
DOI: 10.1016/j.anscip.2023.03.044

Progress toward species-tailored prematuration approaches in carnivores

Autores: Alberto Maria Luciano, Federica Franciosi, Pritha Dey, Magdalena Ladron De Guevara, Noemi Monferini, Sai Kamal Nag Bonumallu, Giulia Musmeci, Fernanda Fagali Franchi, Rodrigo Garcia Barros, Martina Colombo, Valentina Lodde
Publicado en: Theriogenology, Edición 196, 2023, Página(s) 202-213, ISSN 0093-691X
Editor: Elsevier BV
DOI: 10.1016/j.theriogenology.2022.11.016

Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth

Autores: Lais Barbosa Latorraca, António Galvão, Maria Belen Rabaglino, Julieta Maria D’Augero, Gavin Kelsey, Trudee Fair
Publicado en: BMC Genomics, Edición 25, 2024, ISSN 1471-2164
Editor: BioMed Central
DOI: 10.1186/s12864-024-10234-0

Alternative culture systems for bovine oocyte<i>in vitro</i>maturation: liquid marbles and differentially shaped 96-well plates

Autores: Andrea Fernández-Montoro, Daniel Angel-Velez, Camilla Benedetti, Nima Azari-Dolatabad, Osvaldo Bogado Pascottini, Krishna Chaitanya Pavani, Ann Van Soom
Publicado en: Animals, 2022, ISSN 2076-2615
Editor: MDPI
DOI: 10.1101/2022.10.24.513502

3D culture of ovarian follicles in granular and nanofibrillar hydrogels

Autores: Marko Mihajlovic, Dóra Katalin Pásztor-Jánoska, Jesús Cadenas, Cristina Subiran Adrados, Claus Yding Andersen, Stine Gry Kristensen, Johan Ulrik Lind
Publicado en: Biomaterials Advances, Edición 164, 2024, Página(s) 213987, ISSN 2772-9508
Editor: Elsevier
DOI: 10.1016/j.bioadv.2024.213987

Specific processing of meiosis-related transcript is linked to final maturation in human oocytes

Autores: Sara Pietroforte, Montserrat Barragan Monasterio, Anna Ferrer-Vaquer, Manuel Irimia, Elena Ibáñez, Mina Popovic, Rita Vassena, Filippo Zambelli
Publicado en: Molecular Human Reproduction, Edición 29, 2023, ISSN 1460-2407
Editor: OXFORD UNIVERSITY PRESS
DOI: 10.1093/molehr/gaad021

Exploring the potential use of platelet rich plasma (PRP) from adult and umbilical cord blood in murine follicle culture

Autores: Cristina Subiran Adrados, Jesús Cadenas, Sofie Lund Polat, Anna Sanderhage Tjäder, Paul Blanche, Stine Gry Kristensen
Publicado en: Reproductive Biology, Edición 24, 2024, Página(s) 100851, ISSN 1642-431X
Editor: Elsevier BV
DOI: 10.1016/j.repbio.2023.100851

How to beat the bull: Lycopene as a tool to improve in vitro fertilization efficiency in bulls with high polyspermy

Autores: Andrea Fernández-Montoro, Daniel Angel-Velez, Berta Cava-Cami, Osvaldo Bogado Pascottini, Krishna Chaitanya Pavani, Katrien Smits, Ann Van Soom
Publicado en: Reproductive Biology, Edición 24, 2024, Página(s) 100888, ISSN 1642-431X
Editor: Elsevier BV
DOI: 10.1016/j.repbio.2024.100888

031 Measuring cumulus expansion of bovine cumulus-oocyte complexes: comparing the reliability of three methods

Autores: A. Raes, N. Azari-Dolatabad, G. Athanasiou, J.L. Arcos, J. Cerquides, G. Opsomer, K. Smits, D. Angel-Velez, A. Van Soom
Publicado en: Animal - science proceedings, Edición 14, 2023, Página(s) 449-450, ISSN 2772-283X
Editor: Elsevier
DOI: 10.1016/j.anscip.2023.03.032

Exploring the effect of platelet-rich plasma on vascularization and survival of follicles in xenotransplanted human ovarian tissue

Autores: Cristina Subiran Adrados, Hanna Ørnes Olesen, Sophie Vernimmen Olesen, Susanne Elisabeth Pors, Sussanne Holtze, Thomas Hildebrandt, Claus Yding Andersen, Stine Gry Kristensen
Publicado en: Reproductive BioMedicine Online, Edición 49, 2024, Página(s) 104274, ISSN 1472-6483
Editor: Reproductive Healthcare Ltd
DOI: 10.1016/j.rbmo.2024.104274

In vitro production of naked mole-rats’ blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection

Autores: Raffaella Simone, Daniel Čižmár, Susanne Holtze, Geert Michel, Anje Sporbert, Charlotte Okolo, Thomas B. Hildebrandt
Publicado en: Scientific Reports, Edición 13, 2023, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-49661-6

Age-dependent high-yield isolation of primordial, primary, and early secondary follicles from the bovine ovarian cortex

Autores: Noemi Monferini, Pritha Dey, Ludovica Donadini, Niki Katsakoglou, Federica Franciosi, Valentina Lodde, Alberto Maria Luciano
Publicado en: Reproduction, Edición 167, 2024, ISSN 1470-1626
Editor: Society for Reproduction and Fertility
DOI: 10.1530/rep-24-0060

Ethical assessment of genome resource banking (GRB) in wildlife conservation

Autores: Pierfrancesco Biasetti, Elena Mercugliano, Lisa Schrade, Maria Michela Spiriti, Frank Göritz, Susanne Holtze, Steven Seet, Cesare Galli, Jan Stejskal, Silvia Colleoni, Daniel Čižmár, Raffaella Simone, Thomas B. Hildebrandt, Barbara de Mori
Publicado en: Cryobiology, Edición 117, 2024, Página(s) 104956, ISSN 0011-2240
Editor: Academic Press
DOI: 10.1016/j.cryobiol.2024.104956

Book chapters (2)

Method of Isolation and In Vitro Culture of Primordial Follicles in Bovine Animal Model

Autores: Pritha Dey, Noemi Monferini, Ludovica Donadini, Valentina Lodde, Federica Franciosi, Alberto Maria Luciano
Publicado en: Methods in Molecular Biology, Germ Cell Development, 2024, Página(s) 171-182
Editor: Springer US
DOI: 10.1007/978-1-0716-3698-5_13

Detecting the Area of Bovine Cumulus Oocyte Complexes Using Deep Learning and Semantic Segmentation

Autores: Georgios Athanasiou, Jesus Cerquides, Annelies Raes, Nima Azari-Dolatabad, Daniel Angel-Velez, Ann Van Soom, Josep-Lluis Arcos
Publicado en: Frontiers in Artificial Intelligence and Applications, Artificial Intelligence Research and Development, Edición Volume 356, 2022, Página(s) 249 - 258, ISBN 978-1-64368-326-3
Editor: IOS Press
DOI: 10.3233/faia220346