Personalized Therapies for Atrial Fibrillation. A Translational Approach

Deliverables

Final conference
Website launch
Simulated populations of models to in-silico drug test
Developed in-vitro workbenches and tools for hiPSC-derived atrial-like cardiomyocytes
ESRs definition and advertisement
Computational model population
Repositories for open access
Basic genetic and transcriptome profile toolbox for AF progression assessment
Recruitment completion

Communication plan and reviews
Impedance mapping system for atrial fibrosis quantification
Relationship between AF markers and treatment outcome
Report on network-wide training events
Report on local training activities
Training roadmap
Report on secondments' development

Report on secondments’ development

Atrial mechanic marker library based for echocardiographic imaging
Disease profile based on AF markers and the arrhythmogenicity determinants
Dissemination and exploitation plan and reviews

Data Management Plan

Data Management Plan submitted to the REA

Publications

Personalized Modeling of Atrial Activation and P-waves: a Comparison Between Invasive and Non-Invasive Cardiac Mapping

Author(s): Martinez Diaz, Patricia; Sánchez, Jorge; Nagel, Claudia; Martinez Perez, Marta; Hernández-Romero, Ismael; de la Salud Guillem Sánchez, Maria; Doessel, Olaf; Loewe, Axel
Published in: Computing in Cardiology, Issue 49, 2022, ISSN 2325-887X
Publisher: IEEE
DOI: 10.22489/cinc.2022.334

Effect of Contact Force on Local Electrical Impedance in Atrial Tissue - an In Silico Evaluation

Author(s): Martínez Antón, Carmen; Sánchez, Jorge; Heinkele, Andreas; Anna Unger, Laura; Haas, Annika; Schmidt, Kerstin; Luik, Armin; Loewe, Axel; Doessel, Olaf
Published in: Computing in Cardiology, Issue 49, 2022, ISSN 2325-887X
Publisher: IEEE
DOI: 10.22489/cinc.2022.337

Inflammation-Induced Remodeling and Atrial Arrhythmias in Systemic Lupus Erythematosus: In Silico Insights

Author(s): Sánchez, Jorge; Ruales, Karla Arévalo; Macarulla-Rodríguez, María; Barrios Espinosa, Cristian; Loewe, Axel; Guillem, María S
Published in: Computing in Cardiology, Issue 50, 2023, ISSN 2325-887X
Publisher: IEEE
DOI: 10.22489/cinc.2023.292

Spiral Waves Generation Using an Eikonal-Reaction Cardiac Electrophysiology Model

Author(s): Narimane Gassa; Nejib Zemzemi; Cesare Corrado; Yves Coudière
Published in: FIMH 2021: Functional Imaging and Modeling of the Heart, Issue pp. 523-530, 2021, ISBN 978-3-030-78710-3
Publisher: Springer, Cham
DOI: 10.1007/978-3-030-78710-3_50

Regional Segmentation of the Left Atrium: A Preliminary Test in Atrial Fibrillation Patients

Author(s): S. Hussain, M. Falanga, C. Fabbri, C. Corsi
Published in: Computing in Cardiology 2022, Issue 49, 2022, Page(s) 1-4, ISSN 2325-887X
Publisher: IEEE Press
DOI: 10.22489/cinc.2022.357

Fibrosis Reduces the Coincidence of Repetitive Activations Patterns between the Coronary Sinus and Atrial Regions in Simulated Atrial Fibrillation

Author(s): Van Montfoort, Margot; Marques, Victor; Ozgul, Ozan; Gharaviri, Ali; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Schotten, Ulrich; Zeemering, Stef
Published in: Computing in Cardiology (CinC), Issue 2022, 2022
Publisher: IEEE
DOI: 10.22489/cinc.2022.155

ECGI Periodicity Unraveled: A Deep Learning Approach for the Visualization of Periodic Spatiotemporal Patterns in Atrial Fibrillation Patients

Author(s): Alexander Lacki, Ismael Hernández-Romero, Maria S Guillem, Andreu M Climent
Published in: 2021 Computing in Cardiology (CinC), 2021
Publisher: IEEE
DOI: 10.23919/cinc53138.2021.9662803

In Silico Computation of Electrograms and Local Electrical Impedance to Assess Non-Transmural Fibrosis

Author(s): Martínez Antón, Carme; Sánchez, Jorge; Caslli, Nansi; Heinemann, Lena; Unger, Laura Anna; Loewe, Axel; Dössel, Olaf
Published in: Computing in Cardiology, Issue 50, 2023, ISSN 2325-887X
Publisher: IEEE
DOI: 10.22489/cinc.2023.283

State Space Embedding of Atrial Electrograms to Detect Repetitive Conduction Patterns During Atrial Fibrillation

Author(s): Özgül, Ozan; Maesen, Bart; Schotten, Ulrich; Bonizzi, Pietro; Zeemering, Stef
Published in: 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Issue 2021, 2021
Publisher: IEEE
DOI: 10.1109/EMBC46164.2021.9630766

Left Atrial Appendage Contraction Analysis: A Preliminary Test on Atrial Fibrillation Patients

Author(s): S. Hussain, M. Falanga, A. Dal Monte, C. Tomasi, C. Corsi
Published in: Computing in Cardiology 2023, Issue 50, 2023, Page(s) 1-4, ISSN 2325-887X
Publisher: IEEE Press
DOI: 10.22489/cinc.2023.214

Computer Simulations of Composite Maps for Detection of Atrial Fibrillation Mechanisms

Author(s): Özgül, Ozan; Marques, Victor G; Hermans, Ben; Van Hunnik, Arne; Verheule, Sander; Schotten, Ulrich; Gharaviri, Ali; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Zeemering, Stef
Published in: Computing in Cardiology (CinC), Issue 2022, 2022, ISBN 979-8-3503-0097-0
Publisher: IEEE
DOI: 10.22489/cinc.2022.360

An evaluation on the clinical outcome prediction of rotor detection in noninvasive phase maps.

Author(s): C. Fambuena-Santos1 , I. Hernández-Romero2 , R. Molero1 , A.M. Climent1 , M.S. Guillem1
Published in: Computing in Cardiology 2021, 2021
Publisher: Computing in Cardiology 2021

Diffusion Reaction Eikonal Alternant Model: Towards Fast Simulations of Complex Cardiac Arrhythmias

Author(s): Barrios Espinosa, Cristian Albert; Sánchez, Jorge; Doessel, Olaf; Loewe, Axel
Published in: Computing in Cardiology, Issue 49, 2022, ISSN 2325-887X
Publisher: IEEE
DOI: 10.22489/cinc.2022.054

Discrepancy Between LGE-MRI and Electro-Anatomical Mapping for Regional Detection of Pathological Atrial Substrate

Author(s): Goetz, Christian; Martínez Díaz, Patricia; Sánchez, Jorge; Jadidi, Amir; Eichenlaub, Martin; Dössel, Olaf; Loewe, Axel
Published in: Current Directions in Biomedical Engineering, Issue 9, 2023, ISSN 2364-5504
Publisher: de Gruyter
DOI: 10.1515/cdbme-2023-1121

Tracking of Atrial Fibrillation Drivers Based on Propagation Patterns: an In-Silico Study

Author(s): Marques, Victor G; Gharaviri, Ali; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Zeemering, Stef; Schotten, Uli
Published in: Computing in Cardiology (CinC), Issue 2022, 2022
Publisher: IEEE
DOI: 10.22489/cinc.2022.174

High Coverage and High-Resolution Mapping of Repetitive Patterns During Atrial Fibrillation

Author(s): Ozan Özgül, Ben Hermans, Arne Van Hunnik, Sander Verheule, Ulrich Schotten, Pietro Bonizzi, Stef Zeemering
Published in: Computing in Cardiology (CinC), Issue 2021, 2021, ISBN 978-1-6654-7916-5
Publisher: IEEE
DOI: 10.23919/cinc53138.2021.9662754

Incidence of Distinct Repetitive Atrial Activation Patterns as a Metric for Atrial Fibrillation Complexity

Author(s): Özgül, Ozan; Hermans, BJM; van Hunnik, Arne; Verheule, Sander; Schotten, Ulrich; Bonizzi, Pietro; Zeemering, Stef
Published in: Computing in Cardiology (CinC), Issue 2022, 2022
Publisher: IEEE
DOI: 10.22489/CinC.2022.394

Effect of Segmentation Uncertainty on the ECGI Inverse Problem Solution and Source Localization

Author(s): Gassa, Narimane; Boonstra, Machteld; Ondrusova1, Beata; Svehlikova, Jana; Brooks, Dana; Narayan, Akil; Rababah, Ali Salman; van Dam, Peter; MacLeod, Rob; Tate, Jess; Zemzemi, Nejib
Published in: Comput Cardiol (2010), Issue 51, 2023
Publisher: IEEE
DOI: 10.22489/cinc.2022.275

Refining the Eikonal Model to Reproduce the Influence of Atrial Tissue Geometry on Conduction Velocity

Author(s): Skupien, Nils; Barrios Espinosa, Cristian; Dössel, Olaf; Loewe, Axel
Published in: Current Directions in Biomedical Engineering, Issue 8, 2022, ISSN 2364-5504
Publisher: de Gruyter
DOI: 10.1515/cdbme-2022-1035

Spatial Relationship Between Atrial Fibrillation Drivers and the Presence of Repetitive Conduction Patterns Using Recurrence Analysis on In-Silico Models

Author(s): Victor G Marques, Ali Gharaviri, Simone Pezzuto, Pietro Bonizzi, Stef Zeemering, Ulrich Schotten
Published in: Computing in Cardiology (CinC), Issue 2021, 2021, ISBN 978-1-6654-7916-5
Publisher: IEEE
DOI: 10.23919/cinc53138.2021.9662692

Impact of the Right Atrium on Arrhythmia Vulnerability

Author(s): Fitzen, Nikola André; Martínez Díaz, Patricia; Dössel, Olaf; Loewe, Axel
Published in: Current Directions in Biomedical Engineering, Issue 9, 2023, ISSN 2364-5504
Publisher: de Gruyter
DOI: 10.1515/cdbme-2023-1036

Benchmark of deep learning algorithms for the automatic screening in electrocardiograms transmitted by implantable cardiac devices

Author(s): Narimane Gassa; Benjamin Sacristan; Nejib Zemzemi; Maxime Laborde; Juan Garrido Oliver; Clara Matencio Perabla; Guillermo Jimenez-Perez; Oscar Camara; Sylvain Ploux;Marc Strik; Pierre Bordachar; Remi Dubois
Published in: 2021 Computing in Cardiology (CinC), Issue 2021, 2021, Page(s) 1-4, ISBN 978-1-6654-7916-5
Publisher: IEEE
DOI: 10.23919/cinc53138.2021.9662651

A Novel Mapping Strategy of Repetitive Patterns in Consecutive Recordings to Localize Atrial Fibrillation Sources: an In-Silico Study

Author(s): Victor G Marques, Ali Gharaviri, Simone Pezzuto, Angelo Auricchio, Pietro Bonizzi, Stef Zeemering, Ulrich Schotten
Published in: Computing in Cardiology, Issue 2023, 2023
Publisher: IEEE
DOI: 10.22489/cinc.2023.095

In Silico Study of Local Electrical Impedance Measurements in the Atria - Towards Understanding and Quantifying Dependencies in Human

Author(s): Unger, Laura Anna; Martínez Antón, Carmen; Stritt, Michael; Wakili, Reza; Haas, Annika; Kircher, Michael; Dössel, Olaf; Luik, Armin
Published in: IEEE Transactions on Biomedical Engineering, Issue 70, 2023, Page(s) 533-542, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2022.3196545

High-density and high coverage composite mapping of repetitive atrial activation patterns

Author(s): Özgül, Ozan; Hermans, BJM; van Hunnik, Arne; Verheule, Sander; Schotten, Ulrich; Bonizzi, Pietro; Zeemering, Stef
Published in: Computers in Biology and Medicine, Issue 159, 2023, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.106920

Heart Failure, Female Sex, and Atrial Fibrillation Are the Main Drivers of Human Atrial Cardiomyopathy: Results From the CATCH ME Consortium

Author(s): Joris Winters, Aaron Isaacs, Stef Zeemering, Michal Kawczynski, Bart Maesen, Jos Maessen, Elham Bidar, Bas Boukens, Ben Hermans, Arne van Hunnik, Barbara Casadei, Larissa Fabritz, Winnie Chua, Laura Sommerfeld, Eduard Guasch, Luis Mont, Montserrat Batlle, Stephane Hatem, Paulus Kirchhof, Reza Wakili, Mortiz Sinner, Monica Stoll, Andreas Goette, Sander Verheule, Ulrich Schotten
Published in: Journal of the American Heart Association, Issue 12 (22), 2023, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.123.031220

What determines the optimal pharmacological treatment of atrial fibrillation? Insights from in silico trials in 800 virtual atria

Author(s): Albert Dasí, Michael T.B. Pope, Rohan S. Wijesurendra, Tim R. Betts, Rafael Sachetto, Alfonso Bueno-Orovio, Blanca Rodriguez
Published in: The Journal of Physiology, Issue Volume 601, Issue 18, 2023, Page(s) 4013-4032, ISSN 1469-7793
Publisher: 0022-3751
DOI: 10.1113/jp284730

A novel sequential endocardial mapping strategy for locating atrial fibrillation sources based on repetitive conduction patterns: An in-silico study

Author(s): Marques, Victor Gonçalves; Gharaviri, Ali; Özgül, Ozan; Pezzuto, Simone; Auricchio, Angelo; Bonizzi, Pietro; Zeemering, Stef; Schotten, Ulrich
Published in: Journal of Molecular and Cellular Cardiology Plus, Issue 7, 2024, ISSN 2772-9761
Publisher: International Society for Heart Research (ISHR)
DOI: 10.1016/j.jmccpl.2024.100065

A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway

Author(s): Dominique V. M. Verhaert; Dominique V. M. Verhaert; Dominik Linz; Dominik Linz; Dominik Linz; Dominik Linz; Sevasti Maria Chaldoupi; Sjoerd W. Westra; Dennis W. den Uijl; Suzanne Philippens; Mijke Kerperien; Zarina Habibi; Zarina Habibi; Bianca Vorstermans; Rachel M. A. ter Bekke; Rypko J. Beukema; Reinder Evertz; Martin E. W. Hemels; Justin G. L. M. Luermans; Justin G. L. M. Luermans; Randolph Ma
Published in: Frontiers in Cardiovascular Medicine, Issue 9, 2022, ISSN 2297-055X
Publisher: Frontiers Media
DOI: 10.3389/fcvm.2022.879139

Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation

Author(s): Hermans, BJM; Özgül, Ozan; Wolf, Michael; Marques, Victor G.; van Hunnik, Arne; Verheule, Sander; Chaldoupi, Sevasti-Maria; Linz, Dominik; El Haddad, Milad; Duytschaever, Mattias; Bonizzi, Pietro; Vernooy, Kevin; Sebastien, Knecht; Zeemering, Stef
Published in: Journal of Molecular and Cellular Cardiology Plus, Issue 7, 2024, ISSN 2772-9761
Publisher: International Society for Heart Research (ISHR)
DOI: 10.1016/j.jmccpl.2024.100064

Endomysial fibrosis, rather than overall connective tissue content, is the main determinant of conduction disturbances in human atrial fibrillation

Author(s): Bart Maesen, Sander Verheule, Stef Zeemering, Mark La Meir, Jan Nijs, Stijn Lumeij, Dennis H Lau, Mathieu Granier, Harry Jgm Crijns, Jos G Maessen, Stefan Dhein, Ulrich Schotten
Published in: EP Europace, Issue 24 (6), 2022, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euac026

Incidence, prevalence, and trajectories of repetitive conduction patterns in human atrial fibrillation.

Author(s): Frank van Rosmalen; Bart Maesen; Arne van Hunnik; Ben J. M. Hermans; Pietro Bonizzi; Elham Bidar; Jan Nijs; Jos G. Maessen; Sander Verheule; Tammo Delhaas; Ulrich Schotten; Stef Zeemering
Published in: EP Europace, Issue 23, 2021, Page(s) i123–i132, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaa403

Local Electrical Impedance Mapping of the Atria: Conclusions on Substrate Properties and Confounding Factors

Author(s): Laura Anna Unger, Leonie Schicketanz, Tobias Oesterlein, Michael Stritt, Annika Haas, Carmen Martínez Antón, Kerstin Schmidt, Olaf Doessel and Armin Luik
Published in: Frontiers in Physiology, Issue 12, 2022, Page(s) 788885, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2021.788885

Comparison of Propagation Models and Forward Calculation Methods on Cellular, Tissue and Organ Scale Atrial Electrophysiology

Author(s): Claudia Nagel; Cristian Barrios Espinosa; Karli Gillette; Matthias A.F. Gsell; Jorge Sanchez; Gernot Plank; Olaf Dossel; Axel Loewe
Published in: IEEE Transactions on Biomedical Engineering, Issue 70, 2023, Page(s) 511-522, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2022.3196144

Recommender system for ablation lines to treat complex atrial tachycardia

Author(s): Vila, Muhamed; Rivolta, Massimo W.; Barrios Espinosa, Cristian A.; Unger, Laura A.; Luik, Armin; Loewe, Axel; Sassi, Roberto
Published in: Computer Methods and Programs in Biomedicine, Issue 231, 2023, Page(s) 107406, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/j.cmpb.2023.107406

Implementation of a screening and management pathway for chronic obstructive pulmonary disease in patients with atrial fibrillation

Author(s): Rachel M J van der Velden; Maartje J M Hereijgers; Nazia Arman; Naomi van Middendorp; Frits M E Franssen; Monika Gawalko; Dominique V M Verhaert; Zarina Habibi; Kevin Vernooy; Lukasz Koltowski; Jeroen M Hendriks; Hein Heidbuchel; Lien Desteghe; Sami O Simons; Dominik Linz
Published in: EP Europace, Issue 25, 2023, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euad193

The Right Atrium Affects in silico Arrhythmia Vulnerability in Both Atria

Author(s): Martínez Díaz, Patricia; Sánchez, Jorge; Fitzen, Nikola; Ravens, Ursula; Dössel, Olaf; Loewe, Axel
Published in: Heart Rhythm, Issue epub ahead, 2024, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.01.047

Clinical and electrophysiological predictors of device-detected new-onset atrial fibrillation during 3 years after cardiac surgery.

Author(s): Elham Bidar; Elham Bidar; Stef Zeemering; Martijn Gilbers; Aaron Isaacs; Sander Verheule; Matthias Daniel Zink; Bart Maesen; Bart Maesen; Sander Bramer; Michal Kawczynski; Michal Kawczynski; Isabelle C. Van Gelder; Harry J.G.M. Crijns; Jos G. Maessen; Jos G. Maessen; Ulrich Schotten
Published in: EP Europace, Issue 23(12), 2021, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euab136

Electrocardiographic imaging in the atria

Author(s): Ismael, Hernández-Romero; Rubén, Molero; Carlos, Fambuena-Santos; Clara, Herrero-Martín; Andreu M, Climent; María S, Guillem
Published in: Medical & Biological Engineering & Computing, Issue 61, 2022, Page(s) 879–896, ISSN 1741-0444
Publisher: Springer Nature
DOI: 10.1007/s11517-022-02709-7

Atrial fbrosis identifcation with unipolar electrogram eigenvalue distribution analysis in multi‑electrode arrays

Author(s): Jennifer Riccio, Alejandro Alcaine, Sara Rocher, Laura Martinez-Mateu, Javier Saiz, Eric Invers-Rubio, Maria S. Guillem, Juan Pablo Martínez, Pablo Laguna
Published in: Medical & Biological Engineering & Computing, 2022, ISSN 0140-0118
Publisher: Institute of Electrical Engineers
DOI: 10.1007/s11517-022-02648-3

AF driver detection in pulmonary vein area by electropcardiographic imaging: Relation with a favorable outcome of pulmonary vein isolation

Author(s): Fambuena-Santos C,Hernández-Romero I, Molero R, Atienza F,Climent AM and Guillem MS
Published in: Frontiers in Physiology, Issue Volume 14, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1057700

A Comparison of the Impact of Pharmacological Treatments on Cardioversion, Rate Control, and Mortality in Data-Driven Atrial Fibrillation Phenotypes in Critical Care

Author(s): Lacki, A.; Martinez-Millana, A.
Published in: Bioengineering 2024, Issue 11, 2024, Page(s) 199, ISSN 2306-5354
Publisher: MPDI
DOI: 10.3390/bioengineering11030199

Patient-specific left atrium contraction quantification associated with atrial fibrillation: A region-based approach

Author(s): S. Hussain, M. Falanga, A. Chiaravalloti, C. Tomasi, C. Corsi.
Published in: Computer Methods and Programs in Biomedicine, Issue 249, 2024, Page(s) 1-12, ISSN 1872-7565
Publisher: Elsevier
DOI: 10.1016/j.cmpb.2024.108138

Standardized 2D atrial mapping and its clinical applications

Author(s): Tiantian Wang, Joël Karel, Eric Invers-Rubio, Ismael Hernández-Romero, Ralf Peeters, Pietro Bonizzi, Maria S Guillem
Published in: Computers in Biology and Medicine, 2024, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.107755

Paradigm shifts in electrophysiological mechanisms of atrial fibrillation

Author(s): Ulrich Schotten, Seungyup Lee, Stef Zeemering, Albert L. Waldo
Published in: EP Europace, Issue 23, 2021, ISSN 1099-5129
Publisher: Oxford University Press
DOI: 10.1093/europace/euaa384

Consecutive-Day Ventricular and Atrial Cardiomyocyte Isolations from the Same Heart: Shifting the Cost-Benefit Balance of Cardiac Primary Cell Research

Author(s): Joachim Greiner, Teresa Schiatti, Wenzel Kaltenbacher, Marica Dente, Alina Semenjakin, Thomas Kok, Dominik J Fiegle, Thomas Seidel, Ursula Ravens, Peter Kohl, Rémi Peyronnet , Eva A Rog-Zielinska
Published in: Cells, Issue 11(2):233, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11020233

Numerical Investigation of Methods Used In Commercial Clinical Devices for Solving the ECGI Inverse Problem

Author(s): Gassa, Narimane; Kalinin, Vitaly; Zemzemi, Nejib
Published in: https://hal.science/hal-04124322, Issue 42, 2023
Publisher: Springer, Cham
DOI: 10.1007/978-3-031-35302-4_16

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