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Personalized Therapies for Atrial Fibrillation. A Translational Approach

Project description

DEENESFRITPL

Young researchers are taking atrial fibrillation personally

The heart consists of four chambers that contract and relax in a coordinated way to pump blood. Dysfunction here can lead to shortness of breath, dizziness, and fatigue in mild cases and heart failure in more severe cases. In atrial fibrillation, the heart's two upper chambers (the atria) beat rapidly and irregularly, increasing the risk of stroke and related diseases. There are numerous possible causes and pinpointing the exact one for each patient is critical for effective treatment. PersonalizeAF is developing new technologies for characterisation of atrial fibrillation and complemented by novel strategies for treatment. The joint academic and clinical training network plans to deliver personalised therapies and enhanced outcomes.

Objective

Atrial Fibrillation (AF) is the most common cardiac arrhythmia affecting more than 6 million Europeans with a cost exceeding 1% of the EU health care system budget (13.5 billion annually). New treatment strategies and the progress achieved in research on AF mechanisms and substrate evaluation methods to date have not been commensurate with an equivalent development of the knowledge and technologies required to individually characterize each patient in search of the most efficient therapy.

PersonalizeAF addresses this challenge by delivering an innovative multinational, multi-sectorial, and multidisciplinary research and training programme in new technologies and novel strategies for individualized characterization of AF substrate to and increase treatments’ efficiency.

From the research point of view, PersonalizeAF will integrate data and knowledge from in-vitro, in silico, ex vivo and in vivo animal and human models to: 1) generate an individual description of the state of the atrial muscle identifying the disease mechanisms and characteristics; 2) understanding the potential effect that different therapies have on different atrial substrates; and 3) combining this information to generate a specific profile of the patient and the best therapy for each patient.

With this purpose, PersonalizeAF partnership aggregates relevant scientific staff from the academic and clinical world with highly specialised biomedical companies which will be involved in a high-level personalised training programme that will train a new generation of highly skilled professionals and guarantee ESRs and future PhD students outstanding Career Opportunities in the biomedical engineering, cardiology services and medical devices sectors. PersonalizeAF will disseminate results to a wide spectrum of stakeholders, create awareness in the general public about atrial fibrillation and encourage vocational careers among young students.

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Topic(s)

Call for proposal

H2020-MSCA-ITN-2019

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Funding Scheme

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

Coordinator

UNIVERSITAT POLITECNICA DE VALENCIA
Net EU contribution
€ 501 809,76
Address
Camino de vera sn edificio 3a
46022 Valencia
Spain

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (12)

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EC signature date 11 September 2019
Last update: 13 May 2023

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Permalink: https://cordis.europa.eu/project/id/860974

European Union, 2023