Measuring action potentials in thousands of cells at once streamlines cardiac safety testing
High-throughput screening has revolutionised drug discovery and toxicity testing. However, determining the cardiac safety of potential drugs still remains a time-intensive and costly endeavour beginning with tests on cell lines, followed by computational simulations and lastly human trials. The EU-funded MAREP project plans to deliver a fast, automated and affordable alternative. Scientists have developed a platform that enables simultaneous recording of action potentials from thousands of cardiac cells in culture in response to drug application. It could significantly streamline the drug development process and enhance patient safety.
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