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CORDIS

Electrochemically-enabled high-throughput peptidomics for next-generation precision medicine

Project description

A fast, inexpensive, and effective proteomics platform could transform personalised medicine

The genome comprises all our genes and our genes are the instructions for the synthesis of all the proteins our body makes (proteome) to carry out its myriad of functions. The human genome codes for about 20 000 different proteins but variations in splicing can tremendously amplify that number. Since they are ubiquitous and play a critical role in disease, proteins and even pieces of them (peptides) are important disease biomarkers and therapy targets. Proteomics has tremendous potential for personalised medicine yet faces challenges in terms of the variety of targets and subsequent specificity, sensitivity, throughput, and cost. ElectroMed is building a platform that could overcome these issues, providing a quantum leap in proteomics for personalised medicine and much more.

Objective

The uptake of proteomics for precision or personalised medicine applications requires the development of an effective screening instrument capable of detecting proteins at the low concentrations they are found in biological conditions while addressing their large chemical variability.
The ElectroMed project's objective is to build and validate a proof-of-concept prototype of a programmable high-throughput peptide microarray technology. It is based on the radical vision of integrating electrochemical synthesis of peptide bioreceptors to enable programmable in situ protein detection with nano-functionalised FinFET sensors for high-performance data acquisition within a microfluidic-driven multiplexed platform for parallel screening.
The project will undertake the research and innovation work required to 1) demonstrate multiplexed electrochemical peptide synthesis (EPS), 2) develop new FinFET sensors and 3) integrate EPS and the FinFET sensors in a single cost-effective prototype that we will validate in laboratory-relevant conditions.
The ElectroMed project will achieve a technology breakthrough of the first fully-programmable in situ protein screening instrument. This prototype small-size single instrument will come as a faster, cheaper, and more efficient technology than current protein screening instruments. The potential impact is to significantly ease and reduce the price of protein screening to trigger an uptake of protein detection in healthcare (our primary focus) as well as in the food sector (food authenticity and traceability, allergens, GMOs or toxins detection all along food the value chain), environmental remediation or defense (detection of biological warfare agents).
Electromed has also engaged to investigate COVID19 related peptide biomarkers and technology for the diagnosis of the infection and the relevant peptide protein iterations.

Call for proposal

H2020-FETOPEN-2018-2020

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Sub call

H2020-FETOPEN-2018-2019-2020-01

Coordinator

LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY
Net EU contribution
€ 1 089 900,00
Address
5 AVENUE DES HAUTS FOURNEAUX
4362 Esch Sur Alzette
Luxembourg

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Research Organisations
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Total cost
€ 1 089 900,00

Participants (5)