Prepolarized MRI at Earth Field to seek new contrasts linked to molecular events for very early detection of pathologies

Informations projet

PRIMOGAIA

N° de convention de subvention: 863099

DOI

10.3030/863099

Projet clôturé

Date de signature de la CE 4 Septembre 2019

Date de début 1 Decembre 2019

Date de fin 30 Novembre 2023

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 3 387 821,33

Contribution de l’UE

€ 3 387 821,25

Coordonné par

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (8)

Report on DNP whole body imaging feasibility

This report describes that the project experimental setup is able to realize in vitro images on phantoms with the OMRI contrast mechanism on a size comparable/transposable to large animals or human body.

Report on in vitro DNP EF enzymatic kinetic curve

This report describes how the experimental setup is able to detect and follow a biological activity, in-vitro, with the OMRI technique.

Report on enzymatic image on a small animal model

This report describes the detection of an enzymatic activity inside a small animal with the OMRI technique.

Report on the OMRI enhancement capabilities of synthesized agent

This report gives the obtainable results measured as signal enhancement produced by OMRI in presence of a nitroxide contrast agent for a dedicated OMRI frequency and contrast agent concentration.

User training kit

This document describes the equipment capabilities and the way to use them for an external user. It explains the different imaging techniques in conjunction with contrast agent mechanisms.

Report presenting the first earth field image on a small animal

This report describes the production of small animals images acquired with the project experimental setup.

Report on in vitro contrast switch with biological activity

This report describes how the experimental setup is able to detect a biological activity , in-vitro, with the OMRI technique.

Report with a DNP reproducible enhance spectrum

This report describes the characterization of the frequency response of nitroxide contrast agents with the OMRI technique It gives optimal OMRI frequencies and concentration sensibilities

Demonstrators, pilots, prototypes (3)

Complete whole body system prototype

The MRI acquisition platform is completed by additional “Body-sized” sub-units and their power and control elements: magnetic polarization coil with shielding , Gradient coils for imaging, RF (Radio-frequency) coil for EPR (dynamic) polarization and LF(Low-Frequency) coil for NMR acquisition (receive and transmit).

First in vitro image obtained with the implemented sequence

We will demonstrate that our equipment is able to realize images on a large field of view.

First kernel of earth/low field MRI prototype

MRI acquisition platform available at CNRS Bordeaux for small samples of size below 10cm with standard acquisition sequences and imaging capabilities.

Open Research Data Pilot (1)

Project DMP available

This first version of the DMP provides an analysis of the main elements of the data management policy that will be used by the members of the consortium with regard to the data generated through the life of the projectThe DMP will be released in compliance with the Horizon 2020 FAIR DMP template provided by the European Commission and updated in the end of the project

Websites, patent fillings, videos etc. (1)

Project web site prototype and logo

The project logo is designed and the website is constructed and accessible (public), the project description is available for public access.

Publications

Peer reviewed articles (6)

"Highly Sensitive ""Off/On"" EPR Probes to Monitor Enzymatic Activity"

Auteurs: Sabrina Elkhanoufi, Rachele Stefania, Diego Alberti, Simona Baroni, Silvio Aime, Prof. Simonetta Geninatti Crich
Publié dans: Chemistry - A European Journal, Numéro Numéro 28, 2022, ISSN 0947-6539
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202104563

4‑Amino‑TEMPO loaded liposomes as sensitive EPR and OMRI probes for the detection of phospholipase A2 activity

Auteurs: Diego Alberti, Eric Thiaudiere, Elodie Parzy, Sabrina Elkhanoufi, Sahar Rakhshan, Rachele Stefania, Philippe Massot, Philippe Mellet, Silvio Aime & Simonetta Geninatti Crich
Publié dans: Scientific Reports, Numéro 13, 2023, Page(s) 13725, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-40857-4

Functionalized silica nanoplatform as a bimodal contrast agent for MRI and optical imaging

Auteurs: Sarah Garifo; Dimitri Stanicki; Sébastien Boutry; Lionel Larbanoix; Indiana Ternad; Robert N. Muller; Sophie Laurent
Publié dans: Nanoscale, Numéro 13 (39), 2021, 2021, Page(s) 16509–16524, ISSN 2040-3372
Éditeur: Royal Society of Chemistry (RSC); RSC Pub
DOI: 10.1039/d1nr04972k

Enzymatic activity monitoring through dynamic nuclear polarization in Earth magnetic field

Auteurs: E. Parzy, D. Boudries, Samuel Jacoutot, Muriel Albalat, Nicolas Vanthuyne, J-M Franconi, P. Mellet, E.Thiaudiere, G. Audran, S.R.A. Marque, P.Massot
Publié dans: Journal of Magnetic Resonance, Numéro Volume 333, December 2021, 107095, 2021, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.1016/j.jmr.2021.107095

Neutrophil Elastase-Activatable Prodrugs Based on an Alkoxyamine Platform to Deliver Alkyl Radicals Cytotoxic to Tumor Cells

Auteurs: Seda Seren, Jean-Patrick Joly, Pierre Voisin, Véronique Bouchaud, Gérard Audran, Sylvain R. A. Marque, and Philippe Mellet
Publié dans: Journal of Medicinal Chemistry, Numéro 65, 13, 2022, Page(s) 9253-9266, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.2c00455

A system for in vivo on-demand ultra-low field Overhauser-enhanced 3D-Magnetic resonance imaging

Auteurs: Dahmane Boudries, Philippe Massot, Elodie Parzy, Seda Seren, Philippe Mellet, Jean-Michel Franconi, Sylvain Miraux, Eric Bezançon, Sylvain R.A. Marque , Gérard Audran, Markus Muetzel, Stefan Wintzheimer, Florian Fidler, Eric Thiaudiere
Publié dans: Journal of Magnetic Resonance JMR, Numéro Volume 348, 2023, ISSN 1090-7807
Éditeur: Academic Press
DOI: 10.5281/zenodo.10037370