Deliverables
This report describes that the project experimental setup is able to realize in vitro images on phantoms with the OMRI contrast mechanism on a size comparable/transposable to large animals or human body.
Report on in vitro DNP EF enzymatic kinetic curveThis report describes how the experimental setup is able to detect and follow a biological activity, in-vitro, with the OMRI technique.
Report on enzymatic image on a small animal modelThis report describes the detection of an enzymatic activity inside a small animal with the OMRI technique.
Report on the OMRI enhancement capabilities of synthesized agentThis report gives the obtainable results measured as signal enhancement produced by OMRI in presence of a nitroxide contrast agent for a dedicated OMRI frequency and contrast agent concentration.
User training kitThis document describes the equipment capabilities and the way to use them for an external user. It explains the different imaging techniques in conjunction with contrast agent mechanisms.
Report presenting the first earth field image on a small animalThis report describes the production of small animals images acquired with the project experimental setup.
Report on in vitro contrast switch with biological activityThis report describes how the experimental setup is able to detect a biological activity , in-vitro, with the OMRI technique.
Report with a DNP reproducible enhance spectrumThis report describes the characterization of the frequency response of nitroxide contrast agents with the OMRI technique It gives optimal OMRI frequencies and concentration sensibilities
The MRI acquisition platform is completed by additional “Body-sized” sub-units and their power and control elements: magnetic polarization coil with shielding , Gradient coils for imaging, RF (Radio-frequency) coil for EPR (dynamic) polarization and LF(Low-Frequency) coil for NMR acquisition (receive and transmit).
First in vitro image obtained with the implemented sequenceWe will demonstrate that our equipment is able to realize images on a large field of view.
First kernel of earth/low field MRI prototypeMRI acquisition platform available at CNRS Bordeaux for small samples of size below 10cm with standard acquisition sequences and imaging capabilities.
This first version of the DMP provides an analysis of the main elements of the data management policy that will be used by the members of the consortium with regard to the data generated through the life of the projectThe DMP will be released in compliance with the Horizon 2020 FAIR DMP template provided by the European Commission and updated in the end of the project
The project logo is designed and the website is constructed and accessible (public), the project description is available for public access.
Publications
Author(s):
Sabrina Elkhanoufi, Rachele Stefania, Diego Alberti, Simona Baroni, Silvio Aime, Prof. Simonetta Geninatti Crich
Published in:
Chemistry - A European Journal, Issue Issue 28, 2022, ISSN 0947-6539
Publisher:
John Wiley & Sons Ltd.
DOI:
10.1002/chem.202104563
Author(s):
Diego Alberti, Eric Thiaudiere, Elodie Parzy, Sabrina Elkhanoufi, Sahar Rakhshan, Rachele Stefania, Philippe Massot, Philippe Mellet, Silvio Aime & Simonetta Geninatti Crich
Published in:
Scientific Reports, Issue 13, 2023, Page(s) 13725, ISSN 2045-2322
Publisher:
Nature Publishing Group
DOI:
10.1038/s41598-023-40857-4
Author(s):
Sarah Garifo; Dimitri Stanicki; Sébastien Boutry; Lionel Larbanoix; Indiana Ternad; Robert N. Muller; Sophie Laurent
Published in:
Nanoscale, Issue 13 (39), 2021, 2021, Page(s) 16509–16524, ISSN 2040-3372
Publisher:
Royal Society of Chemistry (RSC); RSC Pub
DOI:
10.1039/d1nr04972k
Author(s):
E. Parzy, D. Boudries, Samuel Jacoutot, Muriel Albalat, Nicolas Vanthuyne, J-M Franconi, P. Mellet, E.Thiaudiere, G. Audran, S.R.A. Marque, P.Massot
Published in:
Journal of Magnetic Resonance, Issue Volume 333, December 2021, 107095, 2021, ISSN 1090-7807
Publisher:
Academic Press
DOI:
10.1016/j.jmr.2021.107095
Author(s):
Seda Seren, Jean-Patrick Joly, Pierre Voisin, Véronique Bouchaud, Gérard Audran, Sylvain R. A. Marque, and Philippe Mellet
Published in:
Journal of Medicinal Chemistry, Issue 65, 13, 2022, Page(s) 9253-9266, ISSN 0022-2623
Publisher:
American Chemical Society
DOI:
10.1021/acs.jmedchem.2c00455
Author(s):
Dahmane Boudries, Philippe Massot, Elodie Parzy, Seda Seren, Philippe Mellet, Jean-Michel Franconi, Sylvain Miraux, Eric Bezançon, Sylvain R.A. Marque , Gérard Audran, Markus Muetzel, Stefan Wintzheimer, Florian Fidler, Eric Thiaudiere
Published in:
Journal of Magnetic Resonance JMR, Issue Volume 348, 2023, ISSN 1090-7807
Publisher:
Academic Press
DOI:
10.5281/zenodo.10037370
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