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Dynamic adaptive microscopy for label-free multi-parametric imaging in biology and medicine

Project description

Deeper in vivo imaging thanks to improved optical microscopy techniques

Although optical microscopy has been extensively used in medical imaging, its use in in vivo studies presents a number of challenges. First, the diffusing nature of light propagation in tissues limits in vivo microscopy to superficial depths. Second, the invasive fluorescent tags allow monitoring of only 1-5 events; this performance is far below the targets set by functional genomics and proteomics. The EU-funded DynAMic project will address these two fundamental limitations. Use of wavefront-shaping adaptive optics will improve the performance of optical systems, while inversion light diffusion techniques will help it reach 10 times deeper into tissue. In addition, advanced image formation techniques will radically improve label-free high-contrast imaging. The new techniques will be tested in ophthalmic imaging.

Field of science

  • /medical and health sciences/basic medicine/neurology
  • /natural sciences/physical sciences/optics
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/clinical medicine/ophthalmology
  • /medical and health sciences/clinical medicine/radiology/medical imaging
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action

Coordinator

IDRYMA TECHNOLOGIAS KAI EREVNAS
Address
N Plastira Str 100
70013 Irakleio
Greece
Activity type
Research Organisations
EU contribution
€ 605 000

Participants (6)

TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 697 092,50
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 597 296,25
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
United Kingdom
EU contribution
€ 649 316,25
Address
North Street 66 College Gate
KY16 9AJ St Andrews
Activity type
Higher or Secondary Education Establishments
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 415 875
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
RAYFOS LTD
United Kingdom
EU contribution
€ 493 657,50
Address
Winton House Winton Square
RG21 8EN Basingstoke
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
IMAGINE OPTIC
France
EU contribution
€ 498 900
Address
18 Rue Charles De Gaulle
91400 Orsay
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)