Personalised Medicine for Intervertebral Disc Regeneration- Integrating Profiling, Predictive Modelling and Gene Activated Biomaterials

Project Information

INTEGRATE

Grant agreement ID: 864104

DOI

10.3030/864104

Project closed

EC signature date 3 March 2020

Start date 1 September 2020

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 543,00

EU contribution

€ 1 999 543,00

Coordinated by

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration

Author(s): Emily E. McDonnell, Niamh Wilson, Marcos N. Barcellona, Tara Ní Néill, Jessica Bagnall, Pieter A. J. Brama, Gráinne M. Cunniffe, Stacey L. Darwish, Joseph S. Butler, Conor T. Buckley
Published in: JOR SPINE, Issue 6, 2023, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1279

Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells

Author(s): Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Pieter A. J. Brama, Conor T. Buckley
Published in: JOR SPINE, Issue 9, 2026, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.70160

Restoring disc matrix homeostasis: Dual-miRNA and human platelet lysate as a novel therapeutic strategy

Author(s): Tara Ní Néill, Niamh Wilson, Jijo Thomas, Jake McDonnell, Stacey L. Darwish, Joseph S. Butler, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley
Published in: Materials Today Bio, Issue 38, 2026, Page(s) 103190, ISSN 2590-0064
Publisher: Elsevier BV
DOI: 10.1016/j.mtbio.2026.103190

In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells

Author(s): Emily E. McDonnell, Tara Ní Néill, Niamh Wilson, Stacey L. Darwish, Joseph S. Butler, Conor T. Buckley
Published in: JOR SPINE, Issue 7, 2024, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1352

Modulation of Inflammation and Regeneration in the Intervertebral Disc Using Enhanced Cell‐Penetrating Peptides for MicroRNA Delivery

Author(s): Marcos N. Barcellona, Tara Ní Néill, Fergal J. O’Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley
Published in: Advanced NanoBiomed Research, Issue 4, 2024, ISSN 2699-9307
Publisher: Wiley
DOI: 10.1002/anbr.202300112

Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity

Author(s): Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Stacey Darwish, Joseph S. Butler, Conor T. Buckley
Published in: JOR SPINE, Issue 9, 2026, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.70201

Comparative Analysis of Dual‐ <scp>miRNA</scp> Mediated Stimulation of Nucleus Pulposus and Bone Marrow Derived Stem Cells for Intervertebral Disc Repair

Author(s): Tara Ní Néill, Niamh Wilson, Jake McDonnell, Fergal J. O'Brien, Caroline M. Curtin, James E. Dixon, Pieter A. J. Brama, Conor T. Buckley
Published in: JOR SPINE, Issue 9, 2026, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.70198

In vitro and ex vivo screening of <scp>microRNA</scp> combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration

Author(s): Tara Ní Néill, Marcos N. Barcellona, Niamh Wilson, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley
Published in: JOR SPINE, Issue 7, 2024, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1366