Personalised Medicine for Intervertebral Disc Regeneration- Integrating Profiling, Predictive Modelling and Gene Activated Biomaterials

Project Information

INTEGRATE

Grant agreement ID: 864104

DOI

10.3030/864104

EC signature date 3 March 2020

Start date 1 September 2020

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 543,00

EU contribution

€ 1 999 543,00

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (4)

Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration

Author(s): Emily E. McDonnell, Niamh Wilson, Marcos N. Barcellona, Tara Ní Néill, Jessica Bagnall, Pieter A. J. Brama, Gráinne M. Cunniffe, Stacey L. Darwish, Joseph S. Butler, Conor T. Buckley
Published in: JOR SPINE, Issue 6, 2023, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1279

In silico modeling the potential clinical effect of growth factor treatment on the metabolism of human nucleus pulposus cells

Author(s): Emily E. McDonnell, Tara Ní Néill, Niamh Wilson, Stacey L. Darwish, Joseph S. Butler, Conor T. Buckley
Published in: JOR SPINE, Issue 7, 2024, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1352

Modulation of Inflammation and Regeneration in the Intervertebral Disc Using Enhanced Cell‐Penetrating Peptides for MicroRNA Delivery

Author(s): Marcos N. Barcellona, Tara Ní Néill, Fergal J. O’Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley
Published in: Advanced NanoBiomed Research, Issue 4, 2024, ISSN 2699-9307
Publisher: Wiley
DOI: 10.1002/anbr.202300112

In vitro and ex vivo screening of <scp>microRNA</scp> combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration

Author(s): Tara Ní Néill, Marcos N. Barcellona, Niamh Wilson, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley
Published in: JOR SPINE, Issue 7, 2024, ISSN 2572-1143
Publisher: Wiley
DOI: 10.1002/jsp2.1366