A revolutionary regenerative therapy for management of chronic inflammatory diseases based on neonatal Mesenchymal Stem Cells

Informations projet

NeoCellBank

N° de convention de subvention: 864301

DOI

10.3030/864301

Projet clôturé

Date de signature de la CE 29 Avril 2019

Date de début 1 Mai 2019

Date de fin 31 Août 2019

Financé au titre de

• INDUSTRIAL LEADERSHIP - Innovation In SMEs

Coût total

€ 71 429,00

Contribution de l’UE

€ 50 000,00

Coordonné par

VETBIOBANK SAS
France

Periodic Reporting for period 1 - NeoCellBank (A revolutionary regenerative therapy for management of chronic inflammatory diseases based on neonatal Mesenchymal Stem Cells)

Période du rapport: 2019-05-01 au 2019-08-31

Résumé du contexte et des objectifs généraux du projet

At Vetbiobank we verified the feasibility of NeoCellBank project to optimize our disruptive cell therapy biomanufacturing platform and release it into market. While we already demonstrated in a Proof of Concept study, long term safety and efficacy of our top-tier candidate, Canipren®-Joint to treat canine osteoarthritis, we plan to improve our manufacturing capability and technology transfer, prior to clinical validation. We assessed all the investment required to complete the project, for which we will pursue financing support of circa €2.5M from the EC scheme of Accelerator project. We have evaluated the potential of NeoCellBank to generate >€13M profit and new employment (+15 new job positions). We have already received proofs of interest from our key stakeholders: 3 public research centers, vet clinical investigators located in France and private pharma and biotech companies; we have already established a partnership to secure our European distribution channels with one top 10 vet pharma company. We concluded to continue with NeoCellBank project, motivated by the confirmation of the uniqueness and competitiveness of our innovation with this feasibility study.

Travail effectué depuis le début du projet jusqu’à la fin de la période considérée dans le rapport et principaux résultats atteints jusqu’à présent

TECHNICAL FEASIBILITY, including: technology definition and transfer; Canipren®-Joint specification; analysis of validation procedures; detailed technical plan to increase TRL to 8; analysis of risks and design of a mitigation and contingency plan.
COMMERCIAL FEASIBILITY, including: market analysis; end-user´s segmentation; main competitors; definition of commercial strategy; SoA and FtO analysis; business model; commercialization and dissemination plan, including IPR strategy.
FINANCIAL FEASIBILITY, including: in-depth cost analysis to evaluate our capacity to take the innovation; business projections for the first five years after NeoCellBank market launch in a conservative sales scenario.

Progrès au-delà de l’état des connaissances et impact potentiel prévu (y compris l’impact socio-économique et les conséquences sociétales plus larges du projet jusqu’à présent)

NeoCellBank will be the first biomanufacturing platform able to yield neonatal MSC-based therapies from placental tissues for vet and human medicinal applications, improving the benefits (higher standardized treatment, higher cell proliferation capacity, and lower immunogenicity, among others) and avoiding ethical constrains usually associated to adult cells, and accelerating cell therapy development process in terms of cost, regulations and time-to-market. It will allow us to grow reaching >€36M revenue and +15 new employees after the 5th year of commercialization.

image.png