Metastasis-associated altered molecular patterns in the brain

Project Information

ALTER-brain

Grant agreement ID: 864759

DOI

10.3030/864759

Project closed

EC signature date 10 February 2020

Start date 1 July 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 897 437,00

EU contribution

€ 1 897 437,00

Coordinated by

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

A Site-Specific MiniAp4–Trastuzumab Conjugate Prevents Brain Metastasis

Author(s): Mariam Masmudi-Martín, Benjamí Oller-Salvia, María Perea, Meritxell Teixidó, Manuel Valiente, Ernest Giralt, Macarena Sánchez-Navarro
Published in: Molecular Pharmaceutics, Issue 22, 2025, Page(s) 1384-1395, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.4c01091

Brain Microenvironment Heterogeneity: Potential Value for Brain Tumors

Author(s): Laura Álvaro-Espinosa, Ana de Pablos-Aragoneses, Manuel Valiente, Neibla Priego
Published in: Frontiers in Oncology, Issue 11, 2023, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2021.714428

Consortium for Intracranial Metastasis Academic Research (CIMARa): Global interdisciplinary collaborations to improve outcomes of patients with brain metastases

Author(s): Carey K Anders, Amanda E D Van Swearingen, Josh Neman, Johanna A Joyce, Diana M Cittelly, Manuel Valiente, Alexandra S Zimmer, Scott R Floyd, Ajay Dhakal, Soma Sengupta, Manmeet S Ahluwalia, Seema Nagpal, Priya U Kumthekar, Sam Emerson, Reva Basho, Kathryn Beal, Nelson S Moss, Evangelia D Razis, Jonathan T Yang, Sarah L Sammons, Solmaz Sahebjam, Hussein A Tawbi
Published in: Neuro-Oncology Advances, Issue 7, 2025, ISSN 2632-2498
Publisher: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdaf049

Brain metastasis models: What should we aim to achieve better treatments?

Author(s): Masmudi-Martín, M; Zhu, L; Sanchez-Navarro, M; Priego, N; Casanova-Acebes, M; Ruiz-Rodado, V; Giralt, E; Valiente, Manuel; Valiente, Manuel; Masmudi-Martín, M.; Zhu, L.; Sanchez-Navarro, M.; Priego, N.; Casanova-Acebes, M.; Ruiz-Rodado, V; Giralt, E.; Valiente, Manuel
Published in: Advanced Drug Delivery Reviews, Issue Volume 169, February 2021, 2021, Page(s) 79-99, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.12.002

TIMP1 Mediates Astrocyte-Dependent Local Immunosuppression in Brain Metastasis Acting on Infiltrating CD8+ T Cells

Author(s): Neibla Priego, Ana de Pablos-Aragoneses, María Perea-García, Valentina Pieri, Carolina Hernández-Oliver, Laura Álvaro-Espinosa, Andrea Rojas, Oliva Sánchez, Ariane Steindl, Eduardo Caleiras, Fernando García, Santiago García-Martín, Osvaldo Graña-Castro, Sandra García-Mulero, Diego Serrano, Paloma Velasco-Beltrán, Borja Jiménez-Lasheras, Leire Egia-Mendikute, Luise Rupp, Antonia Stammbe
Published in: Cancer Discovery, Issue 15, 2025, Page(s) 179-201, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-24-0134

Updating cancer research with patient-focused networks

Author(s): Manuel Valiente, Eva Ortega-Paino
Published in: Trends in Cancer, Issue 10, 2024, Page(s) 1-4, ISSN 2405-8033
Publisher: Elsevier BV
DOI: 10.1016/j.trecan.2023.09.002

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

Author(s): Lucía Zhu Diana Retana Pedro García-Gómez Laura Álvaro-Espinosa Neibla Priego Mariam Masmudi-Martín Natalia Yebra Lauritz Miarka Elena Hernández-Encinas Carmen Blanco-Aparicio Sonia Martínez Cecilia Sobrino Nuria Ajenjo Maria-Jesus Artiga Eva Ortega-Paino Raúl Torres-Ruiz Sandra Rodríguez-Perales RENACER Riccardo Soffietti Luca Bertero Paola Cassoni Tobias Weiss Javier Muñoz Juan Manuel
Published in: EMBO Mol Med, 2022, ISSN 1757-4684
Publisher: EMBO Press
DOI: 10.15252/emmm.202114552

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

Author(s): Cátia Monteiro, Lauritz Miarka, María Perea-García, Neibla Priego, Pedro García-Gómez, Laura Álvaro-Espinosa, Ana de Pablos-Aragoneses, Natalia Yebra, Diana Retana, Patricia Baena, Coral Fustero-Torre, Osvaldo Graña-Castro, Kevin Troulé, Eduardo Caleiras, Patricia Tezanos, Pablo Muela, Elisa Cintado, José Luis Trejo, Juan Manuel Sepúlveda, Pedro González-León, Luis Jiménez-Roldán, Lu
Published in: Nature Medicine, Issue 28, pages 752–765, 2022, Page(s) 752–765, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-022-01749-8

Animal models of brain metastasis

Author(s): Lauritz Miarka, Manuel Valiente
Published in: Neuro-Oncology Advances, Issue 3, 2021, Page(s) v144-v156, ISSN 2632-2498
Publisher: Oxford University Press (OUP)
DOI: 10.1093/noajnl/vdab115

Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits

Author(s): Alberto Sanchez-Aguilera, Mariam Masmudi-Martín, Andrea Navas-Olive, Patricia Baena, Carolina Hernández-Oliver, Neibla Priego, Lluís Cordón-Barris, Laura Alvaro-Espinosa, Santiago García, Sonia Martínez, Miguel Lafarga, Michael Z Lin, Fátima Al-Shahrour, Liset Menendez de la Prida, Manuel Valiente, Cecilia Sobrino, Nuria Ajenjo, Maria-Jesus Artiga, Eva Ortega-Paino, Virginia García-Calvo,
Published in: Cancer Cell, Issue 41, 2023, Page(s) 1637-1649.e11, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2023.07.010

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

Author(s): Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente
Published in: STAR Protocols, Issue 4, 2024, Page(s) 102194, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2023.102194

Non-peer reviewed articles (1)

MIF-induced CD74+ microglia/macrophages are clinically relevant disease-associated subpopulations in brain metastasis and other CNS disorders

Author(s): Laura Álvaro-Espinosa, Angel Marquez-Galera, Neibla Priego, Virginia García-Calvo, María Perea-García, Carolina Hernández-Oliver, Diana Retana, Oliva Sánchez, Ana de Pablos-Aragoneses, Pedro García-Gómez, Osvaldo Graña-Castro, Óscar Lapuente-Santana, Fátima Al-Shahrour, Ana Cayuela, Isabel Peset, Diego Megías, Mihaela Ola, Damir Varešlija, Leonie Young, Yolanda Martí-Mateos, José An
Published in: bioRxiv, 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.09.06.673623