Molecular pathology of anti-viral T cell responses in the central nervous system

Project Information

PATHOCODE

Grant agreement ID: 865026

DOI

10.3030/865026

Project closed

EC signature date 16 March 2020

Start date 1 August 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 954,00

EU contribution

€ 1 999 954,00

Coordinated by

UNIVERSITE DE GENEVE
Switzerland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Tissue-resident memory CD8 ⁺ T cells cooperate with CD4 ⁺ T cells to drive compartmentalized immunopathology in the CNS

Author(s): Ilena Vincenti, Nicolas Page, Karin Steinbach, Alexander Yermanos, Sylvain Lemeille, Nicolas Nunez, Mario Kreutzfeldt, Bogna Klimek, Giovanni Di Liberto, Kristof Egervari, Margot Piccinno, Ghazal Shammas, Alexandre Mariotte, Nicolas Fonta, Nicolas Liaudet, Danielle Shlesinger, Anna Rita Liuzzi, Ingrid Wagner, Cynthia Saadi, Christine Stadelmann, Sai Reddy, Burkhard Becher, Doron Merkler
Published in: Science Translational Medicine, Issue 14, 2024, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abl6058

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis

Author(s): Ghazal Shammas, Margot Piccinno, Kristof Egervari, Sylvain Lemeille, Alexandre Mariotte, Federica Maltese, Alessandra Panzeri, Ingrid Wagner, Nicolas Fonta, Tiphaine Furlan, Mario Kreutzfeldt, Ilena Vincenti, Alexander Yermanos, Nicolas Page, Camilla Bellone, Carmen Picon Muñoz, Giovanni Di Liberto, Doron Merkler
Published in: Neuron, Issue 114, 2026, Page(s) 622-639.e11, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2025.11.006

Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation

Author(s): Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Hornig S, Bauer S, Wagner I, Egervari K, Raber J, Duvoisin RM, Pless O, Merkler D, Friese MA.
Published in: Journal of Experimental Medicine, 2021, ISSN 1540-9538
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20201290

Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity

Author(s): Meike Mitsdoerffer; Giovanni Di Liberto; Sarah Dötsch; Christopher Sie; Ingrid Wagner; Monika Pfaller; Mario Kreutzfeldt; Simon Fräßle; Lilian Aly; Benjamin Knier; Dirk H Busch; Doron Merkler; Thomas Korn
Published in: Brain (2021), Issue 1, 2021, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awab093

G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis

Author(s): Rothammer N, Woo MS, Bauer S, Binkle-Ladisch L, Di Liberto G, Egervari K, Wagner I, Haferkamp U, Pless O, Merkler D, Engler JB, Friese MA
Published in: Science Advances, 2022, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abm5500

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation

Author(s): Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltrán E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M.
Published in: Nature Neuroscience, Issue 1, 2021, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-00780-7

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

Author(s): Marcel S. Woo, Christina Mayer, Lars Binkle-Ladisch, Jana K. Sonner, Sina C. Rosenkranz, Artem Shaposhnykov, Nicola Rothammer, Volodymyr Tsvilovskyy, Svenja M. Lorenz, Lukas Raich, Lukas C. Bal, Vanessa Vieira, Ingrid Wagner, Simone Bauer, Markus Glatzel, Marcus Conrad, Doron Merkler, Marc Freichel, Manuel A. Friese
Published in: Cell, Issue 187, 2026, Page(s) 4043-4060.e30, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.05.031

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Author(s): Marcel S. Woo, Johannes Brand, Lukas C. Bal, Manuela Moritz, Mark Walkenhorst, Vanessa Vieira, Inbal Ipenberg, Nicola Rothammer, Man Wang, Batuhan Dogan, Desirée Loreth, Christina Mayer, Darwin Nagel, Ingrid Wagner, Lena Kristina Pfeffer, Peter Landgraf, Marco van Ham, Kuno M.-J. Mattern, Ingo Winschel, Noah Frantz, Jana K. Sonner, Henrike K. Grosshans, Albert Miguela, Simone Bauer, Nina Meurs, A
Published in: Cell, Issue 188, 2026, Page(s) 4567-4585.e32, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2025.05.029

Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens

Author(s): Giovanni Di Liberto, Kristof Egervari, Alberto Vogrig, Marianna Spatola, Margot Piccinno, Ilena Vincenti, Ingrid Wagner, Mario Kreutzfeldt, Verena Endmayr, Karoline Ostertag, Jasmin Rahimi, Alex Vicino, Anne-Katrin Pröbstel, David Meyronet, Stephan Frank, Marco Prinz, Ekkehard Hewer, Jean-Philippe Brouland, Laurence de Leval, Laura Parkkinen, Bogdan Draganski, Virginie Desestret, Divyanshu Dubey,
Published in: Acta Neuropathologica, Issue 149, 2025, ISSN 1432-0533
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00401-025-02882-7

Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS

Author(s): Andreas Agrafiotis, Raphael Dizerens, Ilena Vincenti, Ingrid Wagner, Raphael Kuhn, Danielle Shlesinger, Marcos Manero-Carranza, Tudor-Stefan Cotet, Kai-Lin Hong, Nicolas Page, Nicolas Fonta, Ghazal Shammas, Alexandre Mariotte, Margot Piccinno, Mario Kreutzfeldt, Benedikt Gruntz, Roy Ehling, Alessandro Genovese, Alessandro Pedrioli, Andreas Dounas, Sören Franzenburg, Hayrettin Tumani, Tania Kümpf
Published in: Acta Neuropathologica, Issue 145, 2023, Page(s) 335-355, ISSN 0001-6322
Publisher: Springer Verlag
DOI: 10.1007/s00401-023-02537-5

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity

Author(s): Nicolas Fonta, Nicolas Page, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto, Sylvain Lemeille, Mario Kreutzfeldt, Anna Lena Kastner, Yusuf I. Ertuna, Ilena Vincenti, Ingrid Wagner, Daniel D. Pinschewer, Doron Merkler
Published in: Journal of Experimental Medicine, Issue 222, 2025, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20241188

Persistent RNA virus infection is short-lived at the single-cell level but leaves transcriptomic footprints

Author(s): Peter Reuther; Katrin Martin; Mario Kreutzfeldt; Matias Ciancaglini; Florian Geier; Diego Calabrese; Doron Merkler; Daniel D. Pinschewer
Published in: Journal of Experimental Medicine, Issue 1, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20210408

Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV

Author(s): Giovanni Di Liberto, Kristof Egervari, Mario Kreutzfeldt, Christian M Schürch, Ekkehard Hewer, Ingrid Wagner, Renaud Du Pasquier, Doron Merkler
Published in: Brain, Issue 145, 2022, Page(s) 2730-2741, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac102