Skip to main content

Major depression as a metabolic disorder: The role of oxygen homeostasis and mitochondrial bioenergetics in depression etiology and therapy

Project description

Novel biomarkers of energy metabolism in depression

Emerging evidence indicates that Major depressive disorder (MDD) is associated with reduced mitochondrial energy production and impaired oxygen homeostasis along with elevated levels of inflammatory activity and oxidative stress. The key objective of the EU-funded MitO2Health project is to investigate the physiological mechanisms underlying MDD. Scientists will assess the clinical and biological status of patients receiving cognitive behavioural therapy (CBT) in comparison with untreated individuals as well as healthy controls. The study will help to identify biomarkers related to individual therapy response and relapse and, thereby, it will contribute to develop novel biologically founded diagnostic criteria for MDD along with paving the way for innovative treatment concepts.

Call for proposal

ERC-2019-COG
See other projects for this call

Host institution

UNIVERSITAET ULM
Address
Helmholtzstrasse 16
89081 Ulm
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 999 363,75

Beneficiaries (1)

UNIVERSITAET ULM
Germany
EU contribution
€ 1 999 363,75
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments