Molecular mechanisms of presynaptic plasticity

Project Information

PreSynPlast

Grant agreement ID: 865634

DOI

10.3030/865634

Project closed

EC signature date 20 February 2020

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 609 937,00

EU contribution

€ 1 609 937,00

Coordinated by

UNIVERSITAET LEIPZIG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (14)

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Author(s): Iron Weichard, Holger Taschenberger, Felix Gsell, Grit Bornschein, Andreas Ritzau-Jost, Hartmut Schmidt, Robert J. Kittel, Jens Eilers, Erwin Neher, Stefan Hallermann, Jana Nerlich
Published in: Proceedings of the National Academy of Sciences, Issue 120, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2305460120

Calcium dependence of neurotransmitter release at a high fidelity synapse

Author(s): Abdelmoneim Eshra, Hartmut Schmidt, Jens Eilers, Stefan Hallermann
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.70408

Presynaptic <scp>ATP</scp> Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission

Author(s): Isabelle Straub, Lukas Kunstmann, Felipe Baeza‐Lehnert, Saad Chowdhry, Robert B. Renden, Gerardo Gonzalez‐Aragón, Bernhard Groschup, Thomas Hofmann, Saša Jovanović, Mandy Sonntag, Daniel Gitler, Michael Schaefer, Jens Eilers, L. Felipe Barros, Johannes Hirrlinger, Stefan Hallermann
Published in: Journal of Neurochemistry, Issue 169, 2025, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.70212

An action potential initiation mechanism in distal axons for the control of dopamine release

Author(s): Changliang Liu, Xintong Cai, Andreas Ritzau-Jost, Paul F. Kramer, Yulong Li, Zayd M. Khaliq, Stefan Hallermann, Pascal S. Kaeser
Published in: Science, 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abn0532

Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures <i>in vivo</i>

Author(s): Manoj Upadhya, Toni Kirmann, Max A Wilson, Christian M Simon, Divya Dhangar, Christian Geis, Robyn Williams, Gavin Woodhall, Stefan Hallermann, Sarosh R Irani, Sukhvir K Wright
Published in: Brain, Issue 147, 2024, Page(s) 2636-2642, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awae129

Lactate Transport via Glial <scp>MCT1</scp> and Neuronal <scp>MCT2</scp> Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose

Author(s): Lennart Söder, Felipe Baeza‐Lehnert, Babak Khodaie, Amr Elgez, Lena Noack, Andrea Lewen, Stefan Hallermann, Gernot Poschet, Karin Borges, Oliver Kann
Published in: Journal of Neurochemistry, Issue 169, 2025, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.70251

Human antibodies neutralizing the alpha-latrotoxin of the European black widow

Author(s): Maximilian Ruschig, Jana Nerlich, Marlies Becker, Doris Meier, Saskia Polten, Karla Cervantes-Luevano, Philipp Kuhn, Alexei Fedorovish Licea-Navarro, Stefan Hallermann, Stefan Dübel, Maren Schubert, Jeffrey Brown, Michael Hust
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1407398

Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons

Author(s): Andreas Ritzau-Jost, Timur Tsintsadze, Martin Krueger, Jonas Ader, Ingo Bechmann, Jens Eilers, Boris Barbour, Stephen M. Smith, Stefan Hallermann
Published in: Cell Reports, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108612

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly

Author(s): Filiz Sila Rizalar, Max T. Lucht, Astrid Petzoldt, Shuhan Kong, Jiachen Sun, James H. Vines, Narasimha Swamy Telugu, Sebastian Diecke, Thomas Kaas, Torsten Bullmann, Christopher Schmied, Delia Löwe, Jason S. King, Wonhwa Cho, Stefan Hallermann, Dmytro Puchkov, Stephan J. Sigrist, Volker Haucke
Published in: Science, Issue 382, 2024, Page(s) 223-230, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adg1075

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Author(s): Steinke S, Kirmann T, Loi EA, Nerlich J, Weichard I, Kuhn P, Bullmann T, Ritzau-Jost A, Rizalar FS, Prüss H, Haucke V, Geis C, Hust M, Hallermann S
Published in: Brain, 2023, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac497

Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials

Author(s): Torsten Bullmann, Thomas Kaas, Andreas Ritzau-Jost, Anne Whner, Toni Kirmann, Filiz Sila Rizalar, Max Holzer, Jana Nerlich, Dmytro Puchkov, Christian Geis, Jens Eilers, Robert J. Kittel, Thomas Arendt, Volker Haucke, Stefan Hallermann
Published in: The Journal of Neuroscience, Issue 44, 2024, Page(s) e0971232024, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.0971-23.2024

LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K _v 1 Loss and Increased Action Potential Broadening

Author(s): Andreas Ritzau-Jost, Felix Gsell, Josefine Sell, Stefan Sachs, Jacqueline Montanaro, Toni Kirmann, Sebastian Maaß, Sarosh R. Irani, Christian Werner, Christian Geis, Markus Sauer, Ryuichi Shigemoto, Stefan Hallermann
Published in: Neurology Neuroimmunology &amp; Neuroinflammation, Issue 11, 2024, ISSN 2332-7812
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/nxi.0000000000200284

Laser microscopy acquisition and analysis of premotor synapses in the murine spinal cord

Author(s): Buettner JM, Kirmann T, Mentis GZ, Hallermann S, Simon CM
Published in: STAR Protocol, 2022, ISSN 2666-1667
Publisher: STAR Protocols
DOI: 10.1016/j.xpro.2022.101236

Direct whole-cell patch-clamp recordings from small boutons in rodent primary neocortical neuron cultures

Author(s): Andreas Ritzau-Jost; Jana Nerlich; Thomas Kaas; Martin Krueger; Timur Tsintsadze; Jens Eilers; Boris Barbour; Stephen M. Smith; Stefan Hallermann
Published in: STAR Protocols, 2023, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2023.102168