Molecular mechanisms of presynaptic plasticity

Informazioni relative al progetto

PreSynPlast

ID dell’accordo di sovvenzione: 865634

DOI

10.3030/865634

Progetto chiuso

Data della firma CE 20 Febbraio 2020

Data di avvio 1 Settembre 2020

Data di completamento 31 Agosto 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 609 937,00

Contributo UE

€ 1 609 937,00

Coordinato da

UNIVERSITAET LEIPZIG
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (14)

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Autori: Iron Weichard, Holger Taschenberger, Felix Gsell, Grit Bornschein, Andreas Ritzau-Jost, Hartmut Schmidt, Robert J. Kittel, Jens Eilers, Erwin Neher, Stefan Hallermann, Jana Nerlich
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 120, 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2305460120

Calcium dependence of neurotransmitter release at a high fidelity synapse

Autori: Abdelmoneim Eshra, Hartmut Schmidt, Jens Eilers, Stefan Hallermann
Pubblicato in: eLife, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.70408

Presynaptic <scp>ATP</scp> Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission

Autori: Isabelle Straub, Lukas Kunstmann, Felipe Baeza‐Lehnert, Saad Chowdhry, Robert B. Renden, Gerardo Gonzalez‐Aragón, Bernhard Groschup, Thomas Hofmann, Saša Jovanović, Mandy Sonntag, Daniel Gitler, Michael Schaefer, Jens Eilers, L. Felipe Barros, Johannes Hirrlinger, Stefan Hallermann
Pubblicato in: Journal of Neurochemistry, Numero 169, 2025, ISSN 0022-3042
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jnc.70212

An action potential initiation mechanism in distal axons for the control of dopamine release

Autori: Changliang Liu, Xintong Cai, Andreas Ritzau-Jost, Paul F. Kramer, Yulong Li, Zayd M. Khaliq, Stefan Hallermann, Pascal S. Kaeser
Pubblicato in: Science, 2022, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abn0532

Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures <i>in vivo</i>

Autori: Manoj Upadhya, Toni Kirmann, Max A Wilson, Christian M Simon, Divya Dhangar, Christian Geis, Robyn Williams, Gavin Woodhall, Stefan Hallermann, Sarosh R Irani, Sukhvir K Wright
Pubblicato in: Brain, Numero 147, 2024, Pagina/e 2636-2642, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awae129

Lactate Transport via Glial <scp>MCT1</scp> and Neuronal <scp>MCT2</scp> Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose

Autori: Lennart Söder, Felipe Baeza‐Lehnert, Babak Khodaie, Amr Elgez, Lena Noack, Andrea Lewen, Stefan Hallermann, Gernot Poschet, Karin Borges, Oliver Kann
Pubblicato in: Journal of Neurochemistry, Numero 169, 2025, ISSN 0022-3042
Editore: Blackwell Publishing Inc.
DOI: 10.1111/jnc.70251

Human antibodies neutralizing the alpha-latrotoxin of the European black widow

Autori: Maximilian Ruschig, Jana Nerlich, Marlies Becker, Doris Meier, Saskia Polten, Karla Cervantes-Luevano, Philipp Kuhn, Alexei Fedorovish Licea-Navarro, Stefan Hallermann, Stefan Dübel, Maren Schubert, Jeffrey Brown, Michael Hust
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/fimmu.2024.1407398

Large, Stable Spikes Exhibit Differential Broadening in Excitatory and Inhibitory Neocortical Boutons

Autori: Andreas Ritzau-Jost, Timur Tsintsadze, Martin Krueger, Jonas Ader, Ingo Bechmann, Jens Eilers, Boris Barbour, Stephen M. Smith, Stefan Hallermann
Pubblicato in: Cell Reports, 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108612

Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly

Autori: Filiz Sila Rizalar, Max T. Lucht, Astrid Petzoldt, Shuhan Kong, Jiachen Sun, James H. Vines, Narasimha Swamy Telugu, Sebastian Diecke, Thomas Kaas, Torsten Bullmann, Christopher Schmied, Delia Löwe, Jason S. King, Wonhwa Cho, Stefan Hallermann, Dmytro Puchkov, Stephan J. Sigrist, Volker Haucke
Pubblicato in: Science, Numero 382, 2024, Pagina/e 223-230, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adg1075

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Autori: Steinke S, Kirmann T, Loi EA, Nerlich J, Weichard I, Kuhn P, Bullmann T, Ritzau-Jost A, Rizalar FS, Prüss H, Haucke V, Geis C, Hust M, Hallermann S
Pubblicato in: Brain, 2023, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awac497

Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials

Autori: Torsten Bullmann, Thomas Kaas, Andreas Ritzau-Jost, Anne Whner, Toni Kirmann, Filiz Sila Rizalar, Max Holzer, Jana Nerlich, Dmytro Puchkov, Christian Geis, Jens Eilers, Robert J. Kittel, Thomas Arendt, Volker Haucke, Stefan Hallermann
Pubblicato in: The Journal of Neuroscience, Numero 44, 2024, Pagina/e e0971232024, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.0971-23.2024

LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic K _v 1 Loss and Increased Action Potential Broadening

Autori: Andreas Ritzau-Jost, Felix Gsell, Josefine Sell, Stefan Sachs, Jacqueline Montanaro, Toni Kirmann, Sebastian Maaß, Sarosh R. Irani, Christian Werner, Christian Geis, Markus Sauer, Ryuichi Shigemoto, Stefan Hallermann
Pubblicato in: Neurology Neuroimmunology &amp; Neuroinflammation, Numero 11, 2024, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/nxi.0000000000200284

Laser microscopy acquisition and analysis of premotor synapses in the murine spinal cord

Autori: Buettner JM, Kirmann T, Mentis GZ, Hallermann S, Simon CM
Pubblicato in: STAR Protocol, 2022, ISSN 2666-1667
Editore: STAR Protocols
DOI: 10.1016/j.xpro.2022.101236

Direct whole-cell patch-clamp recordings from small boutons in rodent primary neocortical neuron cultures

Autori: Andreas Ritzau-Jost; Jana Nerlich; Thomas Kaas; Martin Krueger; Timur Tsintsadze; Jens Eilers; Boris Barbour; Stephen M. Smith; Stefan Hallermann
Pubblicato in: STAR Protocols, 2023, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2023.102168