Artificial Enzyme Modules as Tools in a Tailor-made Biosynthesis

Project Information

ABIONYS

Grant agreement ID: 865885

DOI

10.3030/865885

Project closed

EC signature date 18 February 2020

Start date 1 November 2020

End date 31 October 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 995 707,00

EU contribution

€ 1 995 707,00

Coordinated by

HELSINGIN YLIOPISTO
Finland

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (13)

Multienzymatic Synthesis of γ-Lactam Building Blocks from Unsaturated Esters and Hydroxylamine

Author(s): Jäger, Christina; Nieger, Martin; Rissanen, Kari; Deska, Jan
Published in: European Journal of Organic Chemistry, Issue 07.08.2023, 2023, Page(s) 7, ISSN 1099-0690
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ejoc.202300288

Choline Oxidase and Choline Ionic Liquids in Biocatalytic Heme Peroxidase Cascades

Author(s): Marleen Hallamaa, Janne M. Naapuri, Rafaela A. L. Silva, Andreia A. Rosatella, Jan Deska
Published in: ChemCatChem, Issue 17, 2025, ISSN 1867-3880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/cctc.202401216

Asymmetric One-Pot Total Synthesis of Tenuipesone A/B Through a Tunable Multi-Enzyme Cascade

Author(s): Hallamaa, Marleen; O'Connell, Adam, Björklund, Joel J.; Liu, Yuchang; Deska, Jan
Published in: Chemistry Europe, 2026, Page(s) 9, ISSN 2751-4765
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ceur.202500440

Peroxidase-induced C–N bond formation via nitroso ene and Diels–Alder reactions

Author(s): Jäger, Christina; Gregori, Berhard J.; Aho, J. A. S.; Hallamaa, M.; Deska, J.
Published in: Green Chemistry, 2023, ISSN 1463-9270
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2gc04827b

Guanidium Unmasked: Repurposing Common Amide Coupling Reagents for the Synthesis of Pentasubstituted Guanidine Bases

Author(s): Juhana A. S. Aho, Jere K. Mannisto, Saku P. M. Mattila, Marleen Hallamaa, Jan Deska
Published in: The Journal of Organic Chemistry, Issue 90, 2025, Page(s) 2636-2643, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.4c02645

An Artificial In Vitro Metabolism to Angiopterlactone B Inspired by Traditional Retrosynthesis

Author(s): Kiefer, Alexander K.; Liu, Yu-Chang; Gummerer, Rebecca; Jäger, Christina; Deska, Jan
Published in: Angewandte Chemie International Edition, 2023, ISSN 1521-3757
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anie.202301178

Enzymatic Bromocyclization of α- and γ-Allenols by Chloroperoxidase from Curvularia inaequalis

Author(s): Naapuri, Janne M.; Wagner, Philip K.; Hollmann, Frank; Deska, Jan
Published in: ChemistryOpen, 2022, Page(s) 6, ISSN 2191-1363
Publisher: Wiley-VCH GmbH
DOI: 10.1002/open.202100236

Aerobic C−N Bond Formation through Enzymatic Nitroso-Ene-Type Reactions

Author(s): Jäger, Christina; Haase, Mona; Koschorreck, Katja; Urlacher, Vlada B.; Deska, Jan
Published in: Angewandte Chemie International Edition, 2023, Page(s) 7, ISSN 1521-3757
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anie.202213671

Formaldehyde and its surrogates as a C1 platform for defossilised modern societies

Author(s): Andrea Rodil, Jan Deska, Martin H. G. Prechtl
Published in: Chemical Society Reviews, Issue 54, 2025, Page(s) 11398-11422, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5cs00882d

Coding Synthetic Chemistry Strategies for Furan Valorization into Bacterial Designer Cells

Author(s): Liu, Yu-Chang; Wu, Zhong-Liu; Deska, Jan
Published in: ChemSusChem, 2023, Page(s) e202201790, ISSN 1864-564X
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cssc.202201790

Asymmetric ring contraction of 2-hydroxypyranones by borrowing hydrogen biocatalysis

Author(s): Yuchang Liu, Adam O'Connell, J. D. Rolfes, Jan Deska
Published in: Chemical Science, Issue 16, 2025, Page(s) 17667-17674, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d5sc02591e

Fully Biocatalytic Rearrangement of Furans to Spirolactones

Author(s): Liu, Yu-Chang; Rolfes, J. D.; Björklund, Joel; Deska, Jan
Published in: ACS Catalysis, 2023, Page(s) 7, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.3c00132

Cascade Catalysis Through Bifunctional Lipase Metal Biohybrids for the Synthesis of Enantioenriched O-Heterocycles from Allenes

Author(s): Naapuri; Janne M.; Losada-Garcia, Noelia; Rothemann, R. Alexander; Carmona Pichardo, Manuel; Prechtl, Martin H. G.; Palomo, Jose M.; Deska, Jan
Published in: ChemCatChem, 2022, ISSN 1867-3899
Publisher: Wiley-VCH GmbH
DOI: 10.1002/cctc.202200362

Other (2)

Asymmetric Ring Contraction of 2-Hydroxypyranones by Borrowing Hydrogen Biocatalysis

Author(s): Yuchang Liu, J. D. Rolfes, Jan Deska
Published in: ChemRxiv, 2025
Publisher: Cambridge University Press
DOI: 10.26434/chemrxiv-2025-9hpvb

A Streamlined Chemoenzymatic One-Pot Process for the Enantioselective Total Synthesis of Tenuipesone A/B

Author(s): Marleen Hallamaa, Adam O'Connell, Joel Björklund, Yu-Chang Liu, Jan Deska
Published in: ChemRxiv, 2025
Publisher: Cambridge University Press
DOI: 10.26434/chemrxiv-2025-rbj31

Non-peer reviewed articles (2)

Carbohydrate Binding Modules as Scaffolds for the de novo Design of Catalytically Active Metallopeptides

Author(s): Juhana Aho, Heather Jameson, Lukas Enders, Jan Deska
Published in: ChemRxiv, 2026, Page(s) 6, ISSN 2573-2293
Publisher: Cambridge Open Engage
DOI: 10.26434/chemrxiv-2025-spvxf

Late-Stage Functionalization of Hydroxamic Acid Pharmaceuticals through OxidativeC–N Bond Formation

Author(s): Jain, Itisha; Aho, Juhana A. S.; Deska, Jan
Published in: ChemRxiv, 2026, Page(s) 5, ISSN 2573-2293
Publisher: Cambridge Open Engage
DOI: 10.26434/chemrxiv.10001704/v1