EXpansion and Phenotype Loss Of SMCs In Atherosclerosis: Causal effects and therapeutic possibilities

Project Information

EXPLOSIA

Grant agreement ID: 866240

DOI

10.3030/866240

Project closed

EC signature date 2 March 2020

Start date 1 August 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 875,00

EU contribution

€ 1 998 875,00

Coordinated by

AARHUS UNIVERSITET
Denmark

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

A full data management plan compliant with the Open research Data Pilot and general Open Science regulations

Publications

Peer reviewed articles (7)

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease

Author(s): Julián Albarrán-Juárez, Anton Markov, Anne Louise Jensen, Peter Loof Møller, Anna Katarzyna Uryga, Djordje Djordjevic, Jakob Hansen, Lise Filt Jensen, Diana Sharysh, Charles Pyke, Jaime Moreno, Giulia Borghetti, Julian Bachmann, Kate Herum, Lisa Maria Røge, Matthew Traylor, Michael Nyberg, Mette Nyegaard, Jacob Fog Bentzon
Published in: iScience, Issue 28, 2025, Page(s) 113698, ISSN 2589-0042
Publisher: Cell Press Elsevier
DOI: 10.1016/j.isci.2025.113698

Cholesterol lowering depletes atherosclerotic lesions of smooth muscle cell-derived fibromyocytes and chondromyocytes

Author(s): Laura Carramolino, Julián Albarrán-Juárez, Anton Markov, Esther Hernández-SanMiguel, Diana Sharysh, Vanessa Cumbicus, Daniel Morales-Cano, Verónica Labrador-Cantarero, Peter Loof Møller, Paula Nogales, Alberto Benguria, Ana Dopazo, Fátima Sanchez-Cabo, Carlos Torroja, Jacob F. Bentzon
Published in: Nature Cardiovascular Research, Issue 3, 2024, Page(s) 203-220, ISSN 2731-0590
Publisher: Springer Nature
DOI: 10.1038/s44161-023-00412-w

Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET

Author(s): Paula Nogales, Carlos Velasco, Leticia González-Cintado, Diana Sharysh, Adriana Mota-Cobián, Raúl Izquierdo-Serrano, Carlos Torroja, David del Rio-Aledo, Daniel Morales-Cano, Rubén A. Mota, Alberto Benguría, Ana Dopazo, Fátima Sánchez-Cabo, Jesús Vázquez, Samuel España, Laura Carramolino, Jesús Mateo, Jacob F. Bentzon
Published in: Science Translational Medicine, Issue 17, 2025, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.ado6467

MyD88-dependent signalling promotes the recruitment of fibrous cap smooth muscle cells in murine atherosclerosis

Author(s): Stine Gunnersen, Julián Albarrán-Juárez, Lise Filt Jensen, Laura Alonso-Herranz, Jeong Tangkjær Shim, Charlotte B. Sørensen, Jacob F. Bentzon
Published in: Atherosclerosis, Issue 411, 2026, Page(s) 120573, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2025.120573

Nanoparticle to Nanoparticle Bioorthogonal Detection of Atherosclerosis

Author(s): María Muñoz-Hernando, Paula Nogales, Andrea Rodríguez-San Pedro, Marta Ibañez, Miguel Ángel Morcillo, Leticia González-Cintado, Jacob F. Bentzon, Fernando Herranz
Published in: ACS Applied Materials & Interfaces, Issue 17, 2025, Page(s) 56675-56686, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.5c08945

Mechanisms of fibrous cap formation in atherosclerosis

Author(s): Laura Alonso-Herranz, Julián Albarrán-Juárez, Jacob Fog Bentzon
Published in: Frontiers in Cardiovascular Medicine, 2023, Page(s) 1254114, ISSN 2297-055X
Publisher: Frontiers Media SA
DOI: 10.3389/fcvm.2023.1254114

Fibroblast-like cells accumulate late in human coronary atherosclerosis contributing to necrotic core formation

Author(s): Daniel Morales-Cano, Diana Sharysh, Julián Albarrán-Juárez, Antonio de Molina, Verónica Labrador-Cantarero, Cecilie Markvard Møller, Laura Carramolino, Jacob F Bentzon
Published in: Cardiovascular Research, 2026, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvag002

Other (2)

Mouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations

Author(s): D Sharysh, P Nogales, D Morales-Cano, A Markov, R Izquierdo-Serrano, L Carramolino, J Albarrán-Juárez, JF Bentzon
Published in: 2026
Publisher: openRxiv
DOI: 10.1101/2025.07.24.666663

Mechanical stretch regulates inflammatory signaling in human smooth muscle cells

Author(s): Lise Filt Jensen, Anton Markov, Laura Alonso-Herranz, Emil Aagaard Thomsen, Jacob Giehm Mikkelsen, Jacob Fog Bentzon, Julián Albarrán-Juárez
Published in: 2026
Publisher: openRxiv
DOI: 10.1101/2025.10.29.685276