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Cooperative Intelligence in Swarms of Enzyme-Nanobots

Project description

Studying the collective behaviour of enzyme nanobot swarms

Inspired by flocks of birds and schools of fish, researchers in the nanorobotics field are focussing on achieving the same movement complexity and implementing swarm behaviours in artificial systems. So far, artificial nanobots have been explored at an individual level. The study on how nanobots propel themselves, navigate and communicate in biologically relevant environments has received little attention. To study their cooperative behaviour, the EU-funded i-NANOSWARMS project will develop enzyme-powered nanobot swarms capable of self-propelling using biocompatible and bioavailable fuels. The project will be a proof-of-concept of the pertinence of intelligent nanoswarms to biomedical applications, enhanced drug delivery and medical imaging.

Objective

In nature, systems composed of self-propelling agents display complex behaviors such as signal interpretation, propagation, amplification and engage in collective motion mediated by interactions between different agents and their environment. Examples range from swarming bacteria to schooling fish and flocking birds. These self-organized systems have served as an inspiration for researchers seeking to achieve complexity in artificial systems composed of synthetic agents. A class of agents that has recently been demonstrated is of synthetic nanomachines (nanobots) that can self-propel thanks to the conversion of chemical energy, harvested from the environment, into motion. While most of the artificial nanobots have been explored at individual level, their collective emergent behavior, arising from inter-particle interactions through chemical and hydrodynamic fields, and through environment mediated interactions is yet to be properly studied. Understanding collective effects will be especially useful in biologically relevant environments, where a number of applications for these nanobot systems have been envisioned.

i-NANOSWARMS aims to realize enzyme-powered nanobot swarms capable to self-propel using biocompatible and bioavailable fuels and display collective and cooperative behaviours through communication among them as well as with the host environment. The proposal is divided in three working packages. In WP1, I will create a toolbox of nanobots based on a library of enzymes and nanoparticle architectures to study communication and long-range signal propagation using enzyme cascades. WP2 will be devoted to the collective behavior of nanobot swarms, exploiting biomimetic strategies such as chemotaxis and stigmergy to guide and recruit other nanobots. WP3 aims at studying, as a proof-of-concept of the applicability of intelligent nanoswarms for biomedical applications, cooperative behavior among nanoswarms for enhanced drug delivery and medical imaging.

Host institution

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Net EU contribution
€ 1 999 819,00
Address
CARRER BALDIRI REIXAC PLANTA 2A 10-12
08028 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Total cost
€ 1 999 819,00

Beneficiaries (1)