Molecular Principles of Mammalian Axonemal Dynein Assembly

Project description

Insight into motile cilia assembly

From fertilization to our last breath, motile cilia, tiny microtubule-based projections from the cell’s surface, are essential to our health. Cilia movement is powered by masses of molecular motors, known as axonemal dyneins, which convert energy into microtubule bending. These mighty machines are precisely assembled from many different components. This EU-funded CiliaCircuits project will investigate how the cell manufactures these motors in time and space. It aims to understand how the cell builds the appropriate number of protein components and assemble them in the right motor type. In the long-term, it is hoped that CiliaCircuits will identify novel molecular switches in this process leading to effective therapeutics for motile ciliopathies.

Field of science

/medical and health sciences/basic medicine/medical genetics
/natural sciences/biological sciences/cell biology

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 1 965 459,94

Website

Contact the organisation

Beneficiaries (1)

THE UNIVERSITY OF EDINBURGH

United Kingdom