Periodic Reporting for period 2 - CompHematoPathology (Computational Hematopathology for Improved Diagnostics)
Période du rapport: 2021-12-01 au 2023-05-31
With the help of the ERC CoG grant, I am addressing this problem. Together with my team, we are designing and training machine learning models that are able to robustly classify individual cells and thus contribute to the diagnosis of serious blood diseases such as leukemia. Furthermore, we aim to better understand the basis for these diseases and are thus developing mathematical models that can reproduce the kinetics of blood production.
We use a similar model for the analysis of pathological tissue sections, whose sheer size and complexity (one section shows millions of individual cells) challenges pathologists on a daily basis. Applied to the analysis of subtypes of lymphoma, a group of blood and lymph tumors, we have been able to generate promising initial results, which we are currently validating on a second data set from a different hospital.
To gain insights into changes in the production of blood cells in human bone marrow, we have fitted mathematical models to experimental data from our biomedical collaborators. This approach allows us to identify specific differentiation patterns in time-resolved single cell data.