Harnessing dendritic cell reprogramming for cancer immunotherapy

Project Information

TrojanDC

Grant agreement ID: 866448

DOI

10.3030/866448

Project closed

EC signature date 3 February 2020

Start date 1 October 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 835,00

EU contribution

€ 1 999 835,00

Coordinated by

LUNDS UNIVERSITET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming.

Author(s): Zimmermannova O*, Ferreira AG*, Ascic E, Kurochkin I, Santiago MV, Hansen M, Caiado I, Shapiro E, Michaux J, Humbert M, Soto-Cabrera D, Benonisson H, Silvério-Alves R, Gomez-Jimenez D, Bernardo C, Bauden M, Andersson R, Höglund M, Miharada K, Nakamura Y, Rosa FF, Pires CF, Greiff L, Lindstedt M, Hugues S, Bassani M, Svane IM, Carlos-Filipe Pereira. *equal contributors.
Published in: Science Immunology, Issue in press, 2023, ISSN 2470-9468
Publisher: American Association for the Advancement of Science (AAAS)

Reprogramming Cancer Cells to Antigen-presenting Cells

Author(s): Alexandra Ferreira, Olga Zimmermannova, Ilia Kurochkin, Ervin Ascic, Fritiof Åkerström, Carlos- Pereira
Published in: BIO-PROTOCOL, Issue 13, 2024, ISSN 2331-8325
Publisher: Bio-Protocol, LLC
DOI: 10.21769/bioprotoc.4881

Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells

Author(s): Fábio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Evelyn Halitzki, Tasnim Zahan, Nejc Arh, Olga Zimmermannová, Alexandra G. Ferreira, Hongzhe Li, Stefan Karlsson, Stefan Scheding, Carlos-Filipe Pereira
Published in: Science Immunology, 2022, ISSN 2470-9468
Publisher: American Association for the Advancement of Science.
DOI: 10.1126/sciimmunol.abg5539

Cell Fate Reprogramming in the Era of Cancer Immunotherapy

Author(s): Olga Zimmermannova, Inês Caiado, Alexandra G. Ferreira and Carlos-Filipe Pereira
Published in: Frontiers in Immunology, 2021, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2021.714822

Tractable <em>In Vivo</em> Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells

Author(s): Ervin Ascic, Gaia Fontanari, Maria Thrasyvoulou, César Pérez Bucio, Tommaso Ballocci, Carlos-Filipe Pereira
Published in: Journal of Visualized Experiments, 2025, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/68739

In vivo dendritic cell reprogramming for cancer immunotherapy

Author(s): Ervin Ascic, Fritiof Åkerström, Malavika Sreekumar Nair, André Rosa, Ilia Kurochkin, Olga Zimmermannova, Xavier Catena, Nadezhda Rotankova, Charlotte Veser, Michal Rudnik, Tommaso Ballocci, Tiffany Schärer, Xiaoli Huang, Maria de Rosa Torres, Emilie Renaud, Marta Velasco Santiago, Özcan Met, David Askmyr, Malin Lindstedt, Lennart Greiff, Laure-Anne Ligeon, Irina Agarkova, Inge Marie Svane, Cr
Published in: Science, Issue 386, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adn9083

Transcription factor–mediated reprogramming to antigen-presenting cells

Author(s): Ervin Ascic, Carlos-Filipe Pereira
Published in: Current Opinion in Genetics & Development, Issue 90, 2025, Page(s) 102300, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2024.102300

Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity

Author(s): Luís Henriques-Oliveira, Abigail R. Altman, Ilia Kurochkin, Ervin Ascic, Evelyn Halitzki, Andreea-Medeea Matei, Diogo Pértiga-Cabral, Isabel Ulmert, Signe Holst, Malavika Sreekumar Nair, Pedro P. Cunha, Sun-Mi Park, Stefano Vergani, Michael G. Kharas, Joan Yuan, Katharina Lahl, Fábio F. Rosa, Cristiana F. Pires, Carlos-Filipe Pereira
Published in: Immunity, 2025, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2025.08.001

Thesis and dissertations (2)

Restoring antitumor immunity with dendritic cell reprogramming strategies

Author(s): Alexandra Gabriela Barros Ferreira
Published in: 2023, ISBN 978-91-8021-472-8
Publisher: Lund University

Generating Dendritic Cells by Direct Cell Reprogramming

Author(s): Fábio F. Rosa
Published in: 2021, ISSN 1652-8220
Publisher: Lund University

Intellectual Property Rights

Patent (6)

COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS OR ANTIGEN PRESENTING CELLS, METHODS AND USES THEREOF

Application/Publication number: 17 171166
Date: 2017-05-15
Applicant(s): LUNDS UNIVERSITET

COMPOSITION FOR REPROGRAMMING CELLS INTO PLASMACYTOID DENDRITIC CELLS OR INTERFERON TYPE I-PRODUCING CELLS, METHODS AND USES THEREOF

Application/Publication number: 20 20078429
Date: 2020-10-09
Applicant(s): LUNDS UNIVERSITET

COMPOSITION FOR REPROGRAMMING CELLS INTO PLASMACYTOID DENDRITIC CELLS OR INTERFERON TYPE I-PRODUCING CELLS, METHODS AND USES THEREOF

Application/Publication number: 20 20078429
Date: 2020-10-09
Applicant(s): LUNDS UNIVERSITET

COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS TYPE 2 COMPETENT FOR ANTIGEN PRESENTATION, METHODS AND USES THEREOF

Application/Publication number: 20 20083400
Date: 2020-11-25
Applicant(s): LUNDS UNIVERSITET

COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS OR ANTIGEN PRESENTING CELLS, METHODS AND USES THEREOF

Application/Publication number: 17 171166
Date: 2017-05-15
Applicant(s): LUNDS UNIVERSITET

COMPOSITIONS FOR REPROGRAMMING CELLS INTO DENDRITIC CELLS TYPE 2 COMPETENT FOR ANTIGEN PRESENTATION, METHODS AND USES THEREOF

Application/Publication number: 20 20083400
Date: 2020-11-25
Applicant(s): LUNDS UNIVERSITET