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Uncovering the epigenetic signature of female-specifiC biological networks and key driver genes of coronary ArteRy diseasE

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Publications

Sex dependent gene activity in the human body

Author(s): Robin J. G. Hartman; Michal Mokry; G. Pasterkamp; Hester M. den Ruijter
Published in: Scientific Reports, Issue 2, 2021, ISSN 2045-2322
DOI: 10.1101/2020.04.22.055053

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Author(s): Robin J. G. Hartman, Daniek M. C. Kapteijn, Saskia Haitjema, Mireille N. Bekker, Michal Mokry, Gerard Pasterkamp, Mete Civelek, Hester M. den Ruijter
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
DOI: 10.1038/s41598-020-69451-8

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Author(s): Robin J.G. Hartman, Katie Owsiany, Lijiang Ma, Simon Koplev, Ke Hao, Lotte Slenders, Mete Civelek, Michal Mokry, Jason C. Kovacic, Gerard Pasterkamp, Gary Owens, Johan L.M. Björkegren, Hester M. den Ruijter
Published in: Circulation, Issue 143/7, 2021, Page(s) 713-726, ISSN 0009-7322
DOI: 10.1161/circulationaha.120.051231

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Author(s): Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard P
Published in: Circulation Research, Issue 127/11, 2020, Page(s) 1437-1455, ISSN 0009-7330
DOI: 10.1161/circresaha.120.316770