Uncovering the epigenetic signature of female-specifiC biological networks and key driver genes of coronary ArteRy diseasE

Project Information

UCARE

Grant agreement ID: 866478

DOI 10.3030/866478

EC signature date 16 March 2020

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 979,00

EU contribution € 1 999 979,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

Publications

Peer reviewed articles (7)

Sex differences in the genetic and molecular mechanisms ofcoronary artery disease

Author(s): Sakkers TR, Mokry M, Civelek M, Erdmann J, Pasterkamp G, Diez Benavente E, den Ruijter HM
Published in: Atherosclerosis, 2023, ISSN 0021-9150
Publisher: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2023.117279

X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events

Author(s): Michele F. Buono; Ernest Diez Benavente; Mark Daniels; Barend M. Mol; Joost M. Mekke; Gert J. de Borst; Dominique P. V. de Kleijn; Sander W. van der Laan; Gerard Pasterkamp; Charlotte Onland-Moret; Michal Mokry; Hester M. den Ruijter
Published in: Biology of Sex Differences, Issue 5, 2023, ISSN 2042-6410
Publisher: BioMed Central
DOI: 10.1186/s13293-023-00527-6

Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells inVulnerable Atherosclerotic Plaques

Author(s): Diez Benavente E, Karnewar S, Buono M, Mili E, Hartman RJG, Kapteijn D, Slenders L, Daniels M, Aherrahrou R, Reinberger T, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, Depuydt MAC, de Winther MPJ, Kuiper J, Björkegren JLM, Erdmann J, Civelek M, Mokry M, Owens GK, Pasterkamp G, den Ruijter HM
Published in: Arterioscler Thromb Vasc Biol, 2023, ISSN 1524-4636
Publisher: ATVB
DOI: 10.1161/atvbaha.123.319325

Sex dependent gene activity in the human body

Author(s): Robin J. G. Hartman; Michal Mokry; G. Pasterkamp; Hester M. den Ruijter
Published in: Scientific Reports, Issue 2, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1101/2020.04.22.055053

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Author(s): Robin J. G. Hartman, Daniek M. C. Kapteijn, Saskia Haitjema, Mireille N. Bekker, Michal Mokry, Gerard Pasterkamp, Mete Civelek, Hester M. den Ruijter
Published in: Scientific Reports, Issue 10/1, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-69451-8

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Author(s): Robin J.G. Hartman, Katie Owsiany, Lijiang Ma, Simon Koplev, Ke Hao, Lotte Slenders, Mete Civelek, Michal Mokry, Jason C. Kovacic, Gerard Pasterkamp, Gary Owens, Johan L.M. Björkegren, Hester M. den Ruijter
Published in: Circulation, Issue 143/7, 2021, Page(s) 713-726, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.051231

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Author(s): Marie A.C. Depuydt, Koen H.M. Prange, Lotte Slenders, Tiit Örd, Danny Elbersen, Arjan Boltjes, Saskia C.A. de Jager, Folkert W. Asselbergs, Gert J. de Borst, Einari Aavik, Tapio Lönnberg, Esther Lutgens, Christopher K. Glass, Hester M. den Ruijter, Minna U. Kaikkonen, Ilze Bot, Bram Slütter, Sander W. van der Laan, Seppo Yla-Herttuala, Michal Mokry, Johan Kuiper, Menno P.J. de Winther, Gerard P
Published in: Circulation Research, Issue 127/11, 2020, Page(s) 1437-1455, ISSN 0009-7330
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.120.316770