Project description
Next-generation vaccine against pneumococcal disease
Pneumococcal disease is responsible for over 200 000 deaths every year in Europe alone. Current vaccines are expensive, and developing countries cannot afford to offer the necessary protection to their citizens. At the same time, antibiotic resistance and Streptococcus pneumoniae adaptation further reduce pneumococcal vaccines’ efficacy. British Immunobiology Ltd. has developed a novel pneumococcal vaccine, PnuBioVax™, that offers protection against all pneumococcal strains and is safe to use. During the EU-funded PnuBioVax project, a feasibility study was conducted along with a full analysis of the technical and business potential of this new vaccine. Combined with its low manufacturing cost, PnuBioVax™ can become the vaccine of choice in developing countries, contributing to the global battle against pneumococcal disease.
Objective
Pneumococcal disease, caused by the pathogenic bacteria Streptococcus pneumoniae, is a major cause of mortality in the young and elderly. In Europe, it is responsible for 230,000 annual deaths and an economic burden of € 10B annually. Due to the high cost of the current vaccines, rates of infant disease and death are even higher in developing countries, accounting for 1.6M deaths per year. The introduction of pneumococcal vaccines in Europe over the 20th century was pivotal in the reduction of pneumococcal pneumonia cases by 31%. Despite these good results, vaccine efficiency is now decreasing due to the adaptation of S. pneumoniae to the existing vaccines, but also due to its growing antibiotic resistance.
ImmunoBiology’s (ImmBio) platform technology has been used to create a pneumococcal vaccine called PnuBioVax™ (PBV) that aims to address the burden of the disease by offering protection against 100% of the pneumococcal strains. As a result of low manufacturing costs (<€ 1), PBV could become a game changer in the combat of the disease, facilitating its adoption in developing countries. The manufacturing cost of PBV represents a reduction of >95% compared to PCV13, the market leader, estimated at € 20. The vaccine has already been tested in humans, demonstrating its safety and effectiveness.
ImmBio is an innovative company, established in 1999 in the UK, which develops state-of-the-art vaccines using the ImmBioVax™ (IBV) vaccine platform technology. To date, ImmBio has raised circa € 10M in grants and awards. These funds, allowed the company to take the IBV technology from concept to clinical readiness products. The proposed work in Phase 1 of the SME instrument fits into their overall plan to reach the market by contributing to the financial resources needed to complete PBV’ clinical studies and ensure market uptake.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-1 - SME instrument phase 1
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB22 3AT CAMBRIDGE
United Kingdom
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.