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High-performance biomechanical model of combined immunotherapy and anti-angiogenic cancer treatment

Project description

The vascular road to effective immunotherapy

Tumour growth and treatment delivery are highly dependent on vascularisation of the tumour itself. Tumour cells produce molecules that encourage angiogenesis, supporting their rapid growth and transition from benign tumours to malignant. These molecules also make the blood vessels leaky and porous. The latter helps tumour cells to enter the bloodstream and spread while concurrently compromising delivery of chemo- and immuno-therapies. EU-funded scientists are developing computational models of tumour microenvironments and repair of vascular abnormalities to better understand the effects of optimised vascular perfusion on promising immunotherapies. Predictions will be tested in experimental models.

Call for proposal

H2020-WF-2018-2020

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Sub call

H2020-WF-01-2018

Coordinator

UNIVERSITY OF CYPRUS
Net EU contribution
€ 145 941,12
Address
Avenue Panepistimiou 2109 Aglantzi
1678 Nicosia
Cyprus

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Region
Κύπρος Κύπρος Κύπρος
Activity type
Higher or Secondary Education Establishments
Other funding
€ 145 941,12