The vascular road to effective immunotherapy
Tumour growth and treatment delivery are highly dependent on vascularisation of the tumour itself. Tumour cells produce molecules that encourage angiogenesis, supporting their rapid growth and transition from benign tumours to malignant. These molecules also make the blood vessels leaky and porous. The latter helps tumour cells to enter the bloodstream and spread while concurrently compromising delivery of chemo- and immuno-therapies. EU-funded scientists are developing computational models of tumour microenvironments and repair of vascular abnormalities to better understand the effects of optimised vascular perfusion on promising immunotherapies. Predictions will be tested in experimental models.