Project description
Innovative mid-infrared spectroscopy and bioreactor monitoring
The biologic drug production usually involves the cultivation of mammalian cells in bioreactors. Current on-line monitoring of the bioreactors by mid-infrared spectroscopy systems is expensive, requiring consecutive sterilisations with high water and energy consumption. German IRUBIS developed a single-use silicon attenuated total reflectance (ATR) crystal integrated into a single-use ATR flow cell for read out by a compact Fourier transform infrared spectrometer. It creates a flexible, low-cost, automated system solution and eliminates sterilisation requirements allowing for energy savings. The EU-funded SUPAIR Spectroscopy project will conduct a phase 1 feasibility study to define the technical, market and commercial roadmap to offer a higher-value product.
Objective
The biopharmaceutical industry is poised to reach an impressive market size of more than €300 billion by 2025. The production of biologic drugs is usually performed by cultivating mammalian cells within bioreactors. Those reactors are increasingly being monitored online by means of Process Analytical Technologies (PAT). However state-of-the-art techniques render both sub-optimal product quality and product efficiency. A complete mid-infrared (MIR) spectroscopy system using online Attenuated Total Reflectance (ATR) probes is highly expensive costing around €200,000, €20,000 only for the probes that are not robust enough, requiring consecutive sterilization to be reused (raising water and energy consumption).
IRUBIS GmbH team goal is to make online monitoring of (single-use) bioreactors affordable. IRUBIS innovation comprises a single-use patent-pending silicon ATR crystal integrated in a single-use ATR Flow Cell which is read out by a compact Fourier Transform Infrared (FTIR) Spectrometer. IRUBIS Analytical Technology offers a system that will allow for the first time real-time process control (online) in single-use bioreactors. This means a flexible, highly automated system solution that costs half the price of the competing solutions. Furthermore, it eliminates sterilization requirements allowing for important energy savings.
IRUBIS has been awarded an accelerator program promoted by Merck; Company recent merits also include the Medical valley award (€500,000) and the Exist scholarship (€150,000).
Our business model will be based in two revenue streams: B2B direct sales of developed IRUBIS optical sensors to biopharma companies and sales through partnerships with distributors. The feasibility study we will carry out under this SME Phase 1 project, will define the technical, market and commercial roadmap allowing to offer customers a higher value product.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering manufacturing engineering
- engineering and technology environmental biotechnology bioremediation bioreactors
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors optical sensors
- social sciences economics and business business and management business models
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.2.3. - INDUSTRIAL LEADERSHIP - Innovation In SMEs
MAIN PROGRAMME
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H2020-EU.3. - PRIORITY 'Societal challenges
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H2020-EU.2.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
SME-1 - SME instrument phase 1
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-EIC-SMEInst-2018-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80335 MUNCHEN
Germany
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.