Breakthrough treatment for acute pancreatitis targeting Store-operated calcium entry
Store-operated calcium entry (SOCE), or capacitative calcium entry, is a mechanism by which the emptying of endoplasmic reticulum calcium stores causes calcium influx across the plasma membrane. Calcium overload associated with SOCE hyper-activation has been implicated as a trigger in a cluster of diseases, including acute pancreatitis (AP), which affects over 10 million people globally. Early preclinical data identified a drug candidate targeting the SOCE process, which might lead to a breakthrough in the pharmacological treatment of AP. The EU-funded RAPID project is supporting the completion of the preclinical studies, aiming to prove that the new compound is suitable for systemic application. The results will pave the way for Phase I and II clinical trials.
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