Project description DEENESFRITPL High-resolution optical imaging for deep-tissue therapeutic monitoring Optoacoustic (photoacoustic) imaging enables three-dimensional, high-resolution optical imaging deep inside tissues (through several millimetres to centimetres). Ultra-broadband raster-scan optoacoustic mesoscopy (RSOM), recently developed, offers advanced cross-sectional optical imaging of the skin; it has been successfully introduced into clinical diagnostics in the dermatology field. The EU-funded WINTHER project will develop next-generation fast RSOM (F-RSOM) that is two orders of magnitude faster than the existing RSOM, enabling assessment of endothelial functions. The new RSOM will be aided by a modern computation framework, based on deterministic and artificial intelligence algorithms. It is hoped that the introduction of F-RSOM will improve the clinical accuracy of RSOM to advance its application in therapeutic monitoring of cardiometabolic diseases and inflammatory skin conditions. Show the project objective Hide the project objective Objective Optoacoustic (photoacoustic) imaging dramatically improves upon conventional bio-optic barriers and enables three-dimensional, high-resolution optical imaging deep inside tissues (several mm to cm). Clinical optoacoustic macroscopy has been supported by two ERC Advanced Awards (2008, 2016; Prof. Ntziachristos). In parallel, under the ICT program INNODERM, we developed mesoscopic optoacoustic imaging for dermatology diagnostics. Termed raster-scan optoacoustic mesoscopy (RSOM), the method can image previously invisible ❶ pathophysiological/oxygenation and ❷ morphological features of the skin at depths of 1-5mm. RSOM has already shown clinical diagnostic value in dermatology and, fuelled by INNODERM, has been commercialised and globally placed by iThera Medical. WINTHER builds on this success. While INNODERM focused on diagnostic dermatology, it has become apparent that RSOM can also assess progression and therapy not only in skin but also in cardiovascular diseases and diabetes. However, to achieve this, RSOM should be able to assess endothelial function, ability that it is not yet available. WINTHER will build next-generation fast RSOM (F-RSOM), operating up to two orders of magnitude faster than state-of-the-art RSOM, enabling it to assess not only ❶,❷ above but also ❸ endothelial function. Using the skin as a window for disease assessment and aided by a modern computation framework, based on deterministic and artificial intelligence algorithms, F-RSOM aims to improve the clinical accuracy of RSOM and shift the paradigm in therapeutic monitoring of cardio-metabolic diseases and inflammatory skin conditions, strengthening Europe's leadership in photonics and in personalized medicine. The project is driven iThera Medical with a strong history of commercializing optoacoustics for clinical applications, by leading physicians (TUM, HUNIMED), and by RSOM, RSOM components and data analysis experts (TUM, iThera, Rayfos, Sonaxis). Fields of science natural sciencescomputer and information sciencesartificial intelligencemedical and health sciencesclinical medicinedermatologymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health scienceshealth sciencespersonalized medicine Programme(s) H2020-EU.2.1.1. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT) Main Programme Topic(s) ICT-05-2019 - Application driven Photonics components Call for proposal H2020-ICT-2018-20 See other projects for this call Sub call H2020-ICT-2019-2 Funding Scheme IA - Innovation action Coordinator TECHNISCHE UNIVERSITAET MUENCHEN Net EU contribution € 1 521 091,25 Address Arcisstrasse 21 80333 Muenchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SONAXIS France Net EU contribution € 470 741,25 Address Rue emilie du chatelet 1 25000 Besancon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bourgogne-Franche-Comté Franche-Comté Doubs Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 201 746,25 RAYFOS LTD United Kingdom Net EU contribution € 493 500,00 Address Winton house winton square RG21 8EN Basingstoke See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 211 500,00 ITHERA MEDICAL GMBH Germany Net EU contribution € 946 837,50 Address Zielstattstrasse 13 81379 Munchen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 405 787,50 HUMANITAS UNIVERSITY Italy Net EU contribution € 860 000,00 Address Via rita levi montalcini snc 20090 Pieve emanuele See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
