Fast optoacoustic mesoscopy, using the skin as a window for therapeutic monitoring of local and systemic disease.

Project Information

WINTHER

Grant agreement ID: 871763

DOI 10.3030/871763

EC signature date 5 December 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)

Total cost € 5 111 203,75

EU contribution € 4 292 170,00

Coordinated by

TECHNISCHE UNIVERSITAET MUENCHEN
Germany

Deliverables

Websites, patent fillings, videos etc. (2)

Public promotion leaflet and F-RSOM postcard

Public awareness documents containing EU Horizon 2020 WINTHER and partner logos and impressive images generated by FRSOM and explanation of WINTHER goals achievements and impact

Project web site

Creation of a project logo and web site comprising a public domain and a password-protected area. The public area will serve as reference point for the public and industry (project description, accomplishments, activities), while the internal use-only area will provide secure data and information exchange for the consortium partners (containing the management and quality manual, and a data and document repository and description of WINTHER goals).

Publications

Peer reviewed articles (10)

Enabling precision monitoring of psoriasis treatment by optoacoustic mesoscopy

Author(s): Hindelang, B., Nau, T., Englert, L., Berezhnoi, A., Lauffer, F., Darsow, U., Biedermann, T., Eyerich, K., Aguirre, J., and Ntziachristos, V.
Published in: Science Translational Medicine, 2022, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.abm8059

Machine learning analysis of human skin by optoacoustic mesoscopy for automated extraction of psoriasis and aging biomarkers

Author(s): Hailong He, Johannes C. Paetzold, Nils Börner, Erik Riedel, Stefan Gerl, Simon Schneider, Chiara Fisher, Ivan Ezhov, Suprosanna Shit, Hongwei Li, Daniel Rückert, Juan Aguirre, Tilo Biedermann, Ulf Darsow, Bjoern Menze and Vasilis Ntziachristos.
Published in: IEEE Transactions on Medical Imaging, 2024, ISSN 1558-254X
Publisher: IEEE Xplore
DOI: 10.1109/tmi.2024.3356180

Raster-scanning optoacoustic mesoscopy biomarkers for atopic dermatitis skin lesions

Author(s): Nau, T., Schönmann, C., Hindelang, B., Riobo, L., Doll, A., Schneider, S., Englert, L., He, H., Biedermann, T., Darsow, U., Lauffer, F., Ntziachristos, V., and Aguirre, J.
Published in: Photoacoustics, 2023, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2023.100513

Optoacoustic imaging in endocrinology and metabolism

Author(s): Karlas, A., Pleitez, M.A., Aguirre, J., and Ntziachristos, N.
Published in: Nature Reviews Endocrinology, Issue 17(6), 2021, Page(s) 323-335, ISSN 1759-5037
Publisher: Springer Nature
DOI: 10.1038/s41574-021-00482-5

Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy

Author(s): Hailong He; Nikolina-Alexia Fasoula; Angelos Karlas; Murad Omar; Juan Aguirre; Jessica Lutz; Michael Kallmayer; Martin Füchtenbusch; Hans-Henning Eckstein; Annette Ziegler; Vasilis Ntziachristos
Published in: Light: Science & Applications, Vol 12, Iss 1, Pp 1-15 (2023), Issue 4, 2023, ISSN 2047-7538
Publisher: Nature
DOI: 10.1038/s41377-023-01275-3

Quality control in clinical raster-scan optoacoustic mesoscopy.

Author(s): Hailong He, Chiara Fischer, Ulf Darsow, Juan Aguirre, Vasilis Ntziachristos
Published in: Photoacoustics, 2023, ISSN 2213-5979
Publisher: Elsevier GmbH
DOI: 10.1016/j.pacs.2023.100582

Fast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo

Author(s): He, H., Schönmann, C., Schwarz, M., Hindelang, B., Bereznhoi, A., Steimle-Grauer, A., Darsow, U., Aguirre, J., and Ntziachristos, V.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30471-9

Fast 3D Optoacoustic Mesoscopy of Neuromelanin Through Entire Human Midbrain Organoids at Single-Cell Resolution

Author(s): Englert, L., Lacalle-Aurioles, M., Mohamed, N.-V., Lépine, P., Mathur, M., Ntziachristos, V., Durcan T.M. and Aguirre, J.
Published in: Laser and Photonics Reviews, 2023, ISSN 1863-8880
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/lpor.202300443

Enabling the autofocus approach for parameter optimization in planar measurement geometry clinical optoacoustic imaging

Author(s): Englert, L., Riobo, L., Schönmann, C., Ntziachristos, V., and Aguirre, J.
Published in: Journal of Biophotonics, 2022, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.202200032

Dermal features derived from optoacoustic tomograms via machine learning correlate microangiopathy phenotypes with diabetes stage.

Author(s): Angelos Karlas, Nikoletta Katsouli, Nikolina-Alexia Fasoula, Michail Bariotakis, Nikolaos-Kosmas Chlis, Murad Omar, Hailong He, Dimitrios Iakovakis, Christoph Schäffer, Michael Kallmayer, Martin Füchtenbusch, Annette Ziegler, Hans-Henning Eckstein, Leontios Hadjileontiadis , Vasilis Ntziachristos.
Published in: Nature Biomedical Engineering, 2023, Page(s) 1667–1682, ISSN 2157-846X
Publisher: Nature
DOI: 10.1038/s41551-023-01151-w