Project description DEENESFRITPL Novel fluorescent drug markers for in vivo imaging Preclinical and clinical phases in drug discovery would greatly benefit from accurate information about drug distribution. In terms of safety, fluorescent imaging is much better than radioactive markers used in positron emission tomography. However, current fluorescent markers are large entities with positive or negative charge that could change drug properties. This EU-funded project involves four academic and two industrial interdisciplinary teams that aim to develop non-biased red and near infrared fluorescent dyes for in vivo imaging that do not affect the properties of labelled drugs. Developed dyes will be tested using representative known drugs for monitoring and analysis of their distribution in vitro and in vivo. Show the project objective Hide the project objective Objective Imaging of distribution of drugs in mice delivers accurate information for confirmation that the mechanism of action elaborated in cell-based assays is also operative in vivo. These data are critical for the transfer of drug discovery process from pre-clinical to clinical phase. To enable the imaging, drugs should be labeled with easily detectable moieties, e.g. radioactive markers and fluorescent dyes. Ideally, the markers should not affect in vivo properties of the drugs that can be better achieved with radioactive markers, since they can be selected to be small: e.g. a single atom marker 18F applied in positron emission tomography. Despite this intrinsic advantage, PET suffers from safety issues, since radioactivity is harmful to humans and environment. In terms of safety optical imaging is much better and, therefore, in future can replace PET. However, fluorescent dyes compatible with the optical imaging are usually extended pi-systems carrying overall positive or negative charge. Their conjugation strongly affects properties of the majority of medium sized and low molecular weight drugs that limits the applicability of this method in drug discovery. The interdisciplinary and intersectoral consortium NoBiasFluors consisting of 4 academic and 2 industrial teams aims at achieving a breakthrough solution of this problem. We will develop non-biased red and near infrared fluorescent dyes, which are compatible with in vivo optical imaging and do not affect properties of drugs upon their conjugation. This goal will be achieved by the careful optimization of dye structure, polarity and charge. We will confirm the functionality of the developed dyes for labeling of representative drugs (anticancer N-alkylaminoferrocene-based prodrugs, D-peptides targeting Alzheimer’s disease) and binders of biomolecules (nucleopeptides and lectins) and monitoring their distribution both in cellulo and in vivo (for a selected labeled drug). Fields of science engineering and technologymaterials engineeringsynthetic dyes Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2019 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2019 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG Net EU contribution € 133 400,00 Address Schlossplatz 4 91054 Erlangen Germany See on map Region Bayern Mittelfranken Erlangen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 9 200,00 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CONSIGLIO NAZIONALE DELLE RICERCHE Italy Net EU contribution € 92 000,00 Address Piazzale aldo moro 7 00185 Roma See on map Region Centro (IT) Lazio Roma Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 9 200,00 INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI Romania Net EU contribution € 142 600,00 Address Aleea grigore ghica voda 41a 700487 Iasi See on map Region Macroregiunea Doi Nord-Est Iaşi Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 9 200,00 LIMITED LIABILITY SCIENTIFIC SERVICE COMPANY OTAVA Participation ended Ukraine Net EU contribution € 64 400,00 Address Borshagivska 117/125 office 79 03056 Kyiv See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NAUKOVO VYROBNICHYJ KOOPERATYV LECTINOTEST Ukraine Net EU contribution € 73 600,00 Address Mechanichna 2 79024 Lviv See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INNOVATION DEVELOPMENT CENTER ABN LLC Ukraine Net EU contribution € 165 600,00 Address Pirogov street 2/37 01030 Kiev See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA United States Net EU contribution € 0,00 Address Franklin street 1111 12 floor 94607 Oakland ca See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 27 600,00
