Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis

Project Information

MEPHOS

Grant agreement ID: 872648

DOI

10.3030/872648

Project closed

EC signature date 27 November 2019

Start date 1 April 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 906 200,00

EU contribution

€ 864 800,00

Coordinated by

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Publications

Peer reviewed articles (13)

Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes

Author(s): Valentina Di Francesco, Daniela P. Boso, Thomas L. Moore, Bernhard A. Schrefler, Paolo Decuzzi
Published in: Biomedical Microdevices, Issue 25, 2023, ISSN 1387-2176
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10544-023-00671-1

Management of osteoarthritis: From drug molecules to nano/micromedicines

Author(s): Martina Di Francesco,Agnese Fragassi,Martina Pannuzzo,Miguel Ferreira,Sayanti Brahmachari,Paolo Decuzzi
Published in: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Issue 19390041, 2022, ISSN 1939-0041
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/wnan.1780

An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration

Author(s): Juan Antonio Romero-Torrecilla, José María Lamo-Espinosa, Purificación Ripalda-Cemboráin, Tania López-Martínez, Gloria Abizanda, Luis Riera-Álvarez, Sergio Ruiz de Galarreta-Moriones, Asier López-Barberena, Naiara Rodríguez-Flórez, Reyes Elizalde, Vineetha Jayawarna, José Valdés-Fernández, Miguel Echanove-González de Anleo, Peter Childs, Elena de Juan-Pardo, Manuel Salmeron-Sanchez,
Published in: npj Regenerative Medicine, Issue 8, 2023, ISSN 2057-3995
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41536-023-00330-2

Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis

Author(s): Sean K Bedingfield, Juan M. Colazo, Martina Di Francesco, Fang Yu, Danielle D. Liu, Valentina Di Francesco, Lauren E. Himmel, Mukesh K. Gupta, Hongsik Cho, Karen A. Hasty, Paolo Decuzzi, and Craig L. Duvall
Published in: ACS Nano, Issue 19360851, 2021, Page(s) 14475–14491, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c04005

Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis.

Author(s): Martina Di Francesco; Sean K. Bedingfield; Valentina Di Francesco; Valentina Di Francesco; Juan M. Colazo; Fang Yu; Luca Ceseracciu; Elena Bellotti; Daniele Di Mascolo; Miguel Ferreira; Lauren E. Himmel; Craig L. Duvall; Paolo Decuzzi
Published in: ACS Applied Materials and Interfaces, Issue 10895639, 2021, Page(s) 31379-31392, ISSN 1089-5639
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c02082

Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

Author(s): Agnese Fragassi, Antonietta Greco, Martina Di Francesco, Luca Ceseracciu, Aiman Abu Ammar, Israel Dvir, Thomas Lee Moore, Haytam Kasem, Paolo Decuzzi
Published in: Friction, Issue 12, 2024, Page(s) 539-553, ISSN 2223-7690
Publisher: Tsinghua University Press
DOI: 10.1007/s40544-023-0794-y

Optimizing the Fabrication of Shape-Defined Microparticles for Sustained Drug Delivery: The “Less Is More” Paradigm

Author(s): Denise Murgia, Bianca Martins Estevão, Corinne Portioli, Roberto Palomba, Paolo Decuzzi
Published in: ACS Applied Engineering Materials, Issue 2, 2024, Page(s) 2535-2548, ISSN 2771-9545
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsaenm.4c00423

Microstructured Polymeric Fabrics Modulating the Paracrine Activity of Adipose-Derived Stem Cells

Author(s): Federica Grilli, Ennio Albanesi, Beatriz Pelacho, Felipe Prosper, Paolo Decuzzi, Daniele Di Mascolo
Published in: International Journal of Molecular Sciences, Issue 24, 2025, Page(s) 10123, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241210123

Shape-specific microfabricated particles for biomedical applications: a review

Author(s): Thomas L. Moore; Alexander B. Cook; Elena Bellotti; Roberto Palomba; Purnima Manghnani; Raffaele Spanò; Sayanti Brahmachari; Martina Di Francesco; Anna Lisa Palange; Daniele Di Mascolo; Paolo Decuzzi
Published in: Drug Delivery and Translational Research, Issue 2190393X, 2022, Page(s) 2019–2037, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01143-4

Insulin Granule-Loaded MicroPlates for Modulating Blood Glucose Levels in Type-1 Diabetes.

Author(s): Rosita Primavera; Rosita Primavera; Elena Bellotti; Daniele Di Mascolo; Martina Di Francesco; Jing Wang; Bhavesh D. Kevadiya; Angelo De Pascale; Avnesh S. Thakor; Paolo Decuzzi
Published in: ACS Appl Mater Interface, Issue 3, 2021, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.1c16768

Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis

Author(s): Huseyin Ozkan, Martina Di Francesco, Helen Willcockson, José Valdés-Fernández, Valentina Di Francesco, Froilán Granero-Moltó, Felipe Prósper, Paolo Decuzzi & Lara Longobardi
Published in: Drug Delivery and Translational Research, Issue 13, 2023, Page(s) 689–701, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01235-1

CC-Chemokine Receptor-2 Expression in Osteoblasts Contributes to Cartilage and Bone Damage during Post-Traumatic Osteoarthritis

Author(s): Helen Willcockson, Huseyin Ozkan, José Valdés-Fernández, Liubov Arbeeva, Esra Mucahit, Layla Musawwir, Lola B. Hooper, Froilán Granero-Moltó, Felipe Prósper, Lara Longobardi
Published in: Biomolecules, Issue 13, 2025, Page(s) 891, ISSN 2218-273X
Publisher: MDPI AG
DOI: 10.3390/biom13060891

New opportunities and old challenges in the clinical translation of nanotheranostics

Author(s): Peter J. Gawne, Miguel Ferreira, Marisa Papaluca, Jan Grimm, Paolo Decuzzi
Published in: Nature Reviews Materials, Issue 8, 2023, Page(s) 783-798, ISSN 2058-8437
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41578-023-00581-x

Thesis and dissertations (2)

Rational development of intra-articular drug delivery systems for the treatment of osteoarthritis

Author(s): FRAGASSI, AGNESE
Published in: Issue 1, 2024
Publisher: University of Genova

Optimization of mimetic periosteum autografts for the treatment of nonunions

Author(s): null null, Romero Juan Antonio
Published in: Issue 1, 2024
Publisher: Universidad de Navarra
DOI: 10.15581/10171/68418