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Publications

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Author(s): Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Published in: Cancer Gene Therapy, 2020, ISSN 0929-1903
Publisher: Nature Publishing Group
DOI: 10.1038/s41417-020-00224-1

Enhanced intracellular delivery of Curcumin by Chitosan-Lipoic acid as reduction-responsive nanoparticles

Author(s): Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Hossein Zhaleh, Luis J. Cruz
Published in: Current Pharmaceutical Biotechnology, 21, 2020, ISSN 1389-2010
Publisher: Bentham Science Publishers
DOI: 10.2174/1389201021999200727153513

Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Author(s): Jomarien García-Couce, Marioly Vernhes, Nancy Bada, Lissette Agüero, Oscar Valdés, José Alvarez-Barreto, Gastón Fuentes, Amisel Almirall, Luis J. Cruz
Published in: International Journal of Molecular Sciences, 22/11, 2021, Page(s) 5730, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22115730

Nanocarriers as a Tool for the Treatment of Colorectal Cancer

Author(s): Ana Luiza C. de S. L. Oliveira, Timo Schomann, Lioe-Fee de Geus-Oei, Ellen Kapiteijn, Luis J. Cruz, Raimundo Fernandes de Araújo Junior
Published in: Pharmaceutics, 13/8, 2021, Page(s) 1321, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics13081321

Urinary Dickkopf-3 and Contrast-Associated Kidney Damage

Author(s): Giuseppina Roscigno, Cristina Quintavalle, Giuseppe Biondi-Zoccai, Francesca De Micco, Giacomo Frati, Alessandra Affinito, Silvia Nuzzo, Gerolama Condorelli, Carlo Briguori
Published in: Journal of the American College of Cardiology, 77/21, 2021, Page(s) 2667-2676, ISSN 0735-1097
Publisher: Elsevier BV
DOI: 10.1016/j.jacc.2021.03.330

Phenotyping placental oxygenation in Lgals1 deficient mice using 19F MRI

Author(s): Philipp Boehm-Sturm, Susanne Mueller, Nancy Freitag, Sophia Borowski, Marco Foddis, Stefan P. Koch, Sebastian Temme, Ulrich Flögel, Sandra M. Blois
Published in: Scientific Reports, 11/1, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-80408-9

Small Molecules for Multi-Wavelength Near-Infrared Fluorescent Mapping of Regional and Sentinel Lymph Nodes in Colorectal Cancer Staging

Author(s): Victor M. Baart, Marion M. Deken, Mark W. Bordo, Shadhvi S. Bhairosingh, Daniela C. F. Salvatori, Hoon Hyun, Maged Henary, Hak Soo Choi, Cornelis F. M. Sier, Peter J. K. Kuppen, Anton G. T. Terwisscha van Scheltinga, Taryn L. March, Adrianus R. P. M. Valentijn, John V. Frangioni, Alexander L. Vahrmeijer
Published in: Frontiers in Oncology, 10, 2020, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2020.586112

Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Author(s): Claudia Morilla, Elianis Perdomo, Ana Karla Hernández, Ramcy Regalado, Amisel Almirall, Gastón Fuentes, Yaima Campos Mora, Timo Schomann, Alan Chan, Luis J. Cruz
Published in: Molecules, 26/11, 2021, Page(s) 3272, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26113272

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Author(s): Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Published in: Molecules, 25/5, 2020, Page(s) 1181, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

The Effects of Crosslinking on the Rheology and Cellular Behavior of Polymer-Based 3D-Multilayered Scaffolds for Restoring Articular Cartilage

Author(s): Yaima Campos, Francisco J. Sola, Gastón Fuentes, Luis Quintanilla, Amisel Almirall, Luis J. Cruz, José C. Rodríguez-Cabello, Yasuhiko Tabata
Published in: Polymers, 13/6, 2021, Page(s) 907, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym13060907

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

Author(s): Pablo Lara, Alan B. Chan, Luis J. Cruz, Andrew F. G. Quest, Marcelo J. Kogan
Published in: Pharmaceutics, 12/11, 2020, Page(s) 1022, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111022

A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma

Author(s): Victor M. Baart, Geertje van der Horst, Marion M. Deken, Shadhvi S. Bhairosingh, Timo Schomann, Vincent Q. Sier, Maaike H. van der Mark, Luisa Iamele, Hugo de Jonge, Massimo Resnati, Andrew P. Mazar, Rob C.M. Pelger, Gabriel van der Pluijm, Peter J.K. Kuppen, Alexander L. Vahrmeijer, Cornelis F.M. Sier
Published in: European Journal of Cancer, 146, 2021, Page(s) 11-20, ISSN 0959-8049
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.ejca.2021.01.001

Prognostic and Clinicopathological Significance of MiR-155 in Breast Cancer: A Systematic Review

Author(s): Anna Maria Grimaldi, Silvia Nuzzo, Gerolama Condorelli, Marco Salvatore, Mariarosaria Incoronato
Published in: International Journal of Molecular Sciences, 21/16, 2020, Page(s) 5834, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21165834

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature

Author(s): Silvia Nuzzo, Valentina Brancato, Alessandra Affinito, Marco Salvatore, Carlo Cavaliere, Gerolama Condorelli
Published in: Cancers, 12/8, 2020, Page(s) 2173, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12082173

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Author(s): Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Published in: International Journal of Molecular Sciences, 21/7, 2020, Page(s) 2313, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072313

Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation

Author(s): Chih Kit Chung, Jomarien García-Couce, Yaima Campos, Dana Kralisch, Katja Bierau, Alan Chan, Ferry Ossendorp, Luis Javier Cruz
Published in: Molecules, 25/9, 2020, Page(s) 2219, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25092219

Combined Targeting of Glioblastoma Stem-Like Cells by Neutralizing RNA-Bio-Drugs for STAT3

Author(s): Carla Lucia Esposito, Silvia Nuzzo, Maria Luigia Ibba, Lucia Ricci-Vitiani, Roberto Pallini, Gerolama Condorelli, Silvia Catuogno, Vittorio de Franciscis
Published in: Cancers, 12/6, 2020, Page(s) 1434, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12061434

Recent Advances in Rare-Earth-Doped Nanoparticles for NIR-II Imaging and Cancer Theranostics

Author(s): Zhenfeng Yu, Christina Eich, Luis J. Cruz
Published in: Frontiers in Chemistry, 8, 2020, ISSN 2296-2646
Publisher: Frontiers in Chemistry
DOI: 10.3389/fchem.2020.00496

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

Author(s): Manuela Cortese, Maria Rosa Gigliobianco, Federico Magnoni, Roberta Censi, Piera Di Martino
Published in: Molecules, 25/13, 2020, Page(s) 3047, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25133047

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

Author(s): Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Pharmaceuticals, 13/8, 2020, Page(s) 172, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph13080172

Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer

Author(s): V. M. Baart, R. D. Houvast, L. F. de Geus-Oei, P. H. A. Quax, P. J. K. Kuppen, A. L. Vahrmeijer, C. F. M. Sier
Published in: EJNMMI Research, 10/1, 2020, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-020-00673-7

Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study

Author(s): Ruben D. Houvast, Victor M. Baart, Shadhvi S. Bhairosingh, Robert A. Cordfunke, Jia Xin Chua, Mireille Vankemmelbeke, Tina Parsons, Peter J. K. Kuppen, Lindy G. Durrant, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Published in: Molecular Imaging and Biology, August 11, 2020, 2020, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-020-01522-8

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

Author(s): Luis J. Cruz, Thamar van Dijk, Olena Vepris, Tracy M.W.Y. Li, Timo Schomann, Fabio Baldazzi, Ryo Kurita, Yukio Nakamura, Frank Grosveld, Sjaak Philipsen, Christina Eich
Published in: Biomaterials, 268, 2021, Page(s) 120580, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120580

CEA, EpCAM, αvβ6 and uPAR Expression in Rectal Cancer Patients with a Pathological Complete Response after Neoadjuvant Therapy

Author(s): Daan Linders , Marion Deken , Maxime van der Valk , Willemieke Tummers , Shadhvi Bhairosingh , Dennis Schaap , Gesina van Lijnschoten , Elham Zonoobi , Peter Kuppen , Cornelis van de Velde , Alexander Vahrmeijer , Arantza Farina Sarasqueta , Cornelis Sier , Denise Hilling
Published in: Diagnostics (Basel), 2021, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/diagnostics11030516

Fluorine‐19 Magnetic Resonance Imaging of Activated Platelets

Author(s): Xiaowei Wang, Sebastian Temme, Christoph Grapentin, Jathushan Palasubramaniam, Aidan Walsh, Wolfgang Krämer, Patricia Kleimann, Asli Havlas, Rolf Schubert, Jürgen Schrader, Ulrich Flögel, Karlheinz Peter
Published in: Journal of the American Heart Association, 9/18, 2020, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.120.016971

Cell-Based Tracers as Trojan Horses for Image-Guided Surgery

Author(s): Vincent Q. Sier, Margreet R. de Vries, Joost R. van der Vorst, Alexander L. Vahrmeijer, Cornelis van Kooten, Luis J. Cruz, Lioe-Fee de Geus-Oei, Valerie Ferreira, Cornelis F. M. Sier, Frauke Alves, Munitta Muthana
Published in: International Journal of Molecular Sciences, 22/2, 2021, Page(s) 755, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020755

Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review

Author(s): Zeger Rijs, A. Naweed Shifai, Sarah E. Bosma, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Stijn Keereweer, Judith V. M. G. Bovée, Michiel A. J. van de Sande, Cornelis F. M. Sier, Pieter B. A. A. van Driel
Published in: Cancers, 13/3, 2021, Page(s) 557, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030557

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer

Author(s): Ana Luiza C. de S.L. Oliveira, Luana Zerillo, Luis J. Cruz, Timo Schomann, Alan B. Chan, Thaís Gomes de Carvalho, Shirley Vitória de P. Souza, Aurigena A. Araújo, Lioe-Fee de Geus-Oei, Raimundo F. de Araújo Júnior
Published in: Materials Science and Engineering: C, 2020, Page(s) 111678, ISSN 0928-4931
Publisher: Elsevier BV
DOI: 10.1016/j.msec.2020.111678

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Author(s): Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Published in: Cancers, 12/12, 2020, Page(s) 3744, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

Identification of a novel RNA aptamer that selectively targets breast cancer exosomes

Author(s): Carla Lucia Esposito, Cristina Quintavalle, Francesco Ingenito, Deborah Rotoli, Giuseppina Roscigno, Silvia Nuzzo, Renato Thomas, Silvia Catuogno, Vittorio de Franciscis, Gerolama Condorelli
Published in: Molecular Therapy - Nucleic Acids, 2021, ISSN 2162-2531
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtn.2021.01.012

Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Author(s): Zili Gu, Candido G. Da Silva, Koen Van der Maaden, Ferry Ossendorp, Luis J. Cruz
Published in: Pharmaceutics, 12/11, 2020, Page(s) 1054, ISSN 1999-4923
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics12111054

Triplet-Triplet Annihilation PLGA-Nanoparticles for Cancer Bioimaging

Author(s): Olena Vepris, Christina Eich, Yansong Feng, Hong Zhang, Eric. L. Kaijzel, Luis J. Cruz
Published in: 2020
Publisher: Biorxiv
DOI: 10.1101/2020.09.02.274969