Fine tune of cellular behavior: multifunctional materials for medical implants

Project Information

Bio-TUNE

Grant agreement ID: 872869

DOI

10.3030/872869

Project closed

EC signature date 27 November 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 814 200,00

EU contribution

€ 814 200,00

Coordinated by

UNIVERSITAT POLITECNICA DE CATALUNYA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (29)

Protease-degradable hydrogels with multifunctional biomimetic peptides for bone tissue engineering

Author(s): Lluís Oliver-Cervelló, Helena Martin-Gómez, Cristina Gonzalez-Garcia, Manuel Salmeron-Sanchez, Maria-Pau Ginebra, Carlos Mas-Moruno
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2023.1192436

Protruding Nanostructured Surfaces for Antimicrobial and Osteogenic Titanium Implants

Author(s): Mohd I. Ishak, Xiayi Liu, Joshua Jenkins, Angela H. Nobbs and Bo Su
Published in: Coatings, Issue 10(8), 2020, Page(s) 756, ISSN 2079-6412
Publisher: MDPI
DOI: 10.3390/coatings10080756

Enhanced and Stem-Cell-Compatible Effects of Nature-Inspired Antimicrobial Nanotopography and Antimicrobial Peptides to Combat Implant-Associated Infection

Author(s): Mohd I. Ishak, Marcus Eales, Laila Damiati, Xiayi Liu, Joshua Jenkins, Matthew J. Dalby, Angela H. Nobbs, Maxim G. Ryadnov, Bo Su
Published in: ACS Applied Nano Materials, Issue 6,4, 2023, Page(s) 2549–2559, ISSN 2574-0970
Publisher: American Chemical Society
DOI: 10.1021/acsanm.2c04913

The role of biomaterials and scaffolds in immune responses in regenerative medicine: macrophage phenotype modulation by biomaterial properties and scaffold architectures

Author(s): Ezgi Antmen; Nihal Engin Vrana; Vasif Hasirci
Published in: Biomaterials Science, Issue 24, 2021, Page(s) 8090-8110, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1bm00840d

Preclinical in vitro evaluation of implantable materials: conventional approaches, new models and future directions

Author(s): Emilie Frisch, Lisa Clavier, Abdessamad Belhamdi, Nihal Engin Vrana, Philippe Lavalle, Benoît Frisch, Béatrice Heurtault, Varvara Gribova
Published in: Frontiers in Bioengineering and Biotechnology, Issue 11, 2023, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2023.1193204

Chemically Diverse Multifunctional Peptide Platforms with Antimicrobial and Cell Adhesive Properties

Author(s): Helena Martin‐Gómez, Lluís Oliver‐Cervelló, Judit Buxadera‐Palomero, Maria‐Pau Ginebra, Carles Mas‐Moruno
Published in: ChemBioChem, Issue 22/5, 2021, Page(s) 839-844, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000670

A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides

Author(s): Helena Martin-Gómez, Lluís Oliver-Cervelló, Iván Sánchez-Campillo, Vicente Marchán, Maria-Pau Ginebra, Carlos Mas-Moruno
Published in: Chemical Communications, Issue 57/8, 2021, Page(s) 982-985, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cc07463b

Characteristics of novel Ti–10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications

Author(s): Wei Xu, Chenjin Hou, Yuxuan Maoc Lei Yang, Maryam Tamaddon, Jianliang Zhang, Xuanhui Qu, Chaozong Liu, Bo Su, Xin Lu
Published in: Bioactive Materials, Issue 5, 2020, Page(s) 659-666, ISSN 2452-199X
Publisher: Elsevier
DOI: 10.1016/j.bioactmat.2020.04.012

Recent Advances in Antiinflammatory Material Design

Author(s): Eloïse Lebaudy, Sylvie Fournel, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova
Published in: Adv. Healthcare Mater., Issue 10, 2021, Page(s) 2001373, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202001373

A portable and affordable aligner for the assembly of microfluidic devices

Author(s): Victoria Guglielmotti, Nicolás Andrés Saffioti, Ana Laura Tohmé, Martín Gambarotta, Gastón Corthey, Diego Pallarola
Published in: HardwareX, Issue 12, 2022, Page(s) e00348, ISSN 2468-0672
Publisher: Elsevier
DOI: 10.1016/j.ohx.2022.e00348

Real-Time Monitoring of Cell Adhesion onto a Soft Substrate by a Graphene Impedance Biosensor

Author(s): Victoria Guglielmotti, Emil Fuhry, Tilmann J. Neubert, Michel Kuhl, Diego Pallarola, Kannan Balasubramanian
Published in: ACS Sensors, Issue 9, 2024, Page(s) 101-109, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.3c01705

Nanotextured titanium inhibits bacterial activity and supports cell growth on 2D and 3D substrate: A co-culture study

Author(s): Mohd I. Ishak, Rosalia Cuahtecontzi Delint, Xiayi Liu, Wei Xu, Penelope M. Tsimbouri, Angela H. Nobbs, Matthew J. Dalby, Bo Su
Published in: Biomaterials Advances, Issue 158, 2024, Page(s) 213766, ISSN 2772-9508
Publisher: Elsevier
DOI: 10.1016/j.bioadv.2024.213766

Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels

Author(s): Man Zhang, Qian Sun, Yiling Liu, Zhiqin Chu, Leixiao Yu, Yong Hou, Heemin Kang, Qiang Wei, Weifeng Zhao, Joachim P. Spatz, Changsheng Zhao, Elisabetta A. Cavalcanti-Adam
Published in: Biomaterials, Issue 268, 2021, Page(s) 120543, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120543

Nanotopography Influences Host–Pathogen Quorum Sensing and Facilitates Selection of Bioactive Metabolites in Mesenchymal Stromal Cells and <i>Pseudomonas aeruginosa</i> Co-Cultures

Author(s): Rosalia Cuahtecontzi Delint, Mohd I. Ishak, Penelope M. Tsimbouri, Vineetha Jayawarna, Karl V. E. Burgess, Gordon Ramage, Angela H. Nobbs, Laila Damiati, Manuel Salmeron-Sanchez, Bo Su, Matthew J. Dalby
Published in: ACS Applied Materials &amp; Interfaces, Issue 16, 2024, Page(s) 43374-43386, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c09291

Biosensors for Studies on Adhesion-Mediated Cellular Responses to Their Microenvironment

Author(s): Nicolás Andrés Saffioti, Elisabetta Ada Cavalcanti-Adam, Diego Pallarola
Published in: Frontiers in Bioengineering and Biotechnology, Issue 8, 2020, Page(s) 1273, ISSN 2296-4185
Publisher: Frontiers Media S.A.
DOI: 10.3389/fbioe.2020.597950

Real‐Time Non‐Faradaic Potentiodynamic Impedance Sensing Using Screen‐Printed Carbon Electrodes

Author(s): Emil Fuhry, Victoria Guglielmotti, Isabell Wachta, Diego Pallarola, Kannan Balasubramanian
Published in: Analysis &amp; Sensing, Issue 4, 2024, ISSN 2629-2742
Publisher: Chemistry Europe - Wiley
DOI: 10.1002/anse.202400037

Influence of nanosecond laser surface patterning on dental 3Y-TZP: Effects on the topography, hydrothermal degradation and cell response

Author(s): N. Garcia-de-Albeniz, M.-P. Ginebra, E. Jimenez-Piqué, J.J. Roa, C. Mas-Moruno
Published in: Dental Materials, Issue 40, 2024, Page(s) 139-150, ISSN 0109-5641
Publisher: Elsevier BV
DOI: 10.1016/j.dental.2023.10.026

Personalization of medical device interfaces: decreasing implant-related complications by modular coatings and immunoprofiling

Author(s): Nihal Engin Vrana, Kaia Palm, Philippe Lavalle
Published in: Future Science OA, Issue 6/8, 2020, Page(s) FSO607, ISSN 2056-5623
Publisher: future science group
DOI: 10.2144/fsoa-2020-0074

Electrochemical Fine-Tuning of the Chemoresponsiveness of Langmuir–Blodgett Graphene Oxide Films

Author(s): Juan M. Devida, Facundo Herrera, M. Antonieta Daza Millone, Félix G. Requejo, Diego Pallarola
Published in: ACS Omega, Issue 8, 2023, Page(s) 27566-27575, ISSN 2470-1343
Publisher: American Chemical Society
DOI: 10.1021/acsomega.3c03220

New trends in the development of multifunctional peptides to functionalize biomaterials

Author(s): Lluís Oliver-Cervelló, Helena Martin-Gómez, Carlos Mas-Moruno
Published in: Journal of Peptide Science, Issue 28, 2022, Page(s) 3335, ISSN 1099-1387
Publisher: Wiley
DOI: 10.1002/psc.3335

Machine Learning‐Based Prediction of Immunomodulatory Properties of Polymers: Toward a Faster and Easier Development of Anti‐Inflammatory Biomaterials

Author(s): Aghilas Akkache, Lisa Clavier, Oleh Mezhenskyi, Kateryna Andriienkova, Thibaut Soubrié, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova
Published in: Advanced NanoBiomed Research, Issue 4, 2024, ISSN 2699-9307
Publisher: Wiley
DOI: 10.1002/anbr.202300085

An Engineered Biomimetic Peptide Regulates Cell Behavior by Synergistic Integrin and Growth Factor Signaling

Author(s): Lluís Oliver-Cervelló, Helena Martin-Gómez, Leslie Reyes, Fatima Noureddine, Elisabetta Ada Cavalcanti-Adam, Maria-Pau Ginebra, Carlos Mas-Moruno
Published in: Advanced Healthcare Materials, Issue 10(7), 2021, Page(s) 2001757, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202001757

Pangenome analysis of <i>Paenibacillus polymyxa</i> strains reveals the existence of multiple and functionally distinct <i>Paenibacillus</i> species

Author(s): Federica Maggi, Anna Maria Giuliodori, Anna Brandi, Lucia Cimarelli, Roberto Alcántara, Stefano Pallotti, Consuelo Amantini, Dezemona Petrelli, Attilio Fabbretti, Roberto Spurio, Valerio Napolioni
Published in: Applied and Environmental Microbiology, Issue 90, 2024, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.01740-24

Mimicking Bone Extracellular Matrix: From BMP-2-Derived Sequences to Osteogenic-Multifunctional Coatings

Author(s): Lluís Oliver-Cervelló, Helena Martin-Gómez, Nandin Mandakhbayar, Young-Woo Jo, Elisabetta Ada Cavalcanti-Adam, Hae-Won Kim, Maria-Pau Ginebra, Jung-Hwan Lee, Carlos Mas-Moruno
Published in: Advanced Healthcare Materials, Issue 11, 2022, Page(s) 2201339, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202201339

FAST, a method based on split-GFP for the detection in solution of proteins synthesized in cell-free expression systems

Author(s): Thuy Duong Pham, Chiara Poletti, Therese Manuela Nloh Tientcheu, Massimiliano Cuccioloni, Roberto Spurio, Attilio Fabbretti, Pohl Milon, Anna Maria Giuliodori
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-58588-5

Design and performance evaluation of additively manufactured composite lattice structures of commercially pure Ti (CP–Ti)

Author(s): Wei Xu, Aihua Yu, Xin Lu, Maryam Tamaddon, Mengdi Wang, Jiazhen Zhang, Jianliang Zhang, Xuanhui Qu, Chaozong Liu, Bo Su
Published in: Bioactive Materials, Issue 6, 2021, Page(s) 1215-1222, ISSN 2452-199X
Publisher: Elsevier
DOI: 10.1016/j.bioactmat.2020.10.005

Surface Co-presentation of BMP-2 and integrin selective ligands at the nanoscale favors α5β1 integrin-mediated adhesion

Author(s): Francesca Posa, Elisabeth H. Baha-Schwab, Qiang Wei, Adriana Di Benedetto, Stefanie Neubauer, Florian Reichart, Horst Kessler, Joachim P. Spatz, Corinne Albiges-Rizo, Giorgio Mori, Elisabetta Ada Cavalcanti-Adam
Published in: Biomaterials, Issue 267, 2021, Page(s) 120484, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120484

A review of surface topographical modification strategies of 3Y-TZP: Effect in the physicochemical properties, microstructure, mechanical reliability, and biological response

Author(s): Nerea García-de-Albeniz, Emilio Jiménez-Piqué, Joan Josep Roa, Carlos Mas-Moruno
Published in: Journal of the European Ceramic Society, Issue 43, 2023, Page(s) 2977-3004, ISSN 0955-2219
Publisher: Elsevier BV
DOI: 10.1016/j.jeurceramsoc.2023.02.043

Bacterial Surface Appendages Modulate the Antimicrobial Activity Induced by Nanoflake Surfaces on Titanium

Author(s): Xiayi Liu, Mohd I. Ishak, Huan Ma, Bo Su, Angela H. Nobbs
Published in: Small, Issue 20, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202310149