Encouraging the triumph of good over evil
Whenever an implant or medical device is inserted in our body, a race for the surface takes place between ‘good‘ eukaryotic cells of our tissues and ‘evil‘ bacteria. In this competitive scenario, the winner takes it all. If bacteria reach first the surface, the success of the implant will be compromised. A possible solution to this problem would be the use of antibiotics. While have revolutionised medicine and our ability to combat bacteria, antibiotics and more generally antibacterial or cytotoxic substances can also inhibit the functioning of healthy cells. The big question is: how can we enhance the adhesion and integration of ‘good‘ healthy cells while simultaneously preventing the formation of ‘evil‘ bacterial biofilms? The EU-funded Bio-TUNE project is addressing these two antagonistic goals with thorough characterisation of eukaryotic and bacterial competition. Insight will aid in development of selective coatings for implants that encourage healthy tissue growth while impeding bacterial colonisation.
Fields of science
Call for proposal
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Funding SchemeMSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)