Alcohol Use Disorders (AUD) is a disease characterised by uncontrolled alcohol consumption. 283 million persons worldwide suffer from alcohol miss use which cause more than 3 million death and 132.6 million disability-adjusted life years.
Alcoholism has also huger damaging effects on families, communities and the overall society. Current drug therapies against AUD are unsuccessful due to low efficacy and poor tolerability. That situation leads to low patient recovery and only 10% of AUD people seeking for treatment.
In this context, KINNOV-THERAPEUTICS has developed a new revolutionary first-in-class drug allowing patients to control their alcohol consumption. KT-110 drug will highly impact the European burden of AUD by decreasing alcohol consumption on AUD patient by 70% leading to triple the number of AUD people seeking for treatment and save more than 5 million lives per year and several billion of social cost expenses. The efficacy of KT-110 is related to its action on a newly discovered pathway highly implicated in alcohol addiction. This major understanding of AUD addiction mechanism was granted the European College of Neuro Psychopharmacology award in April 2009.
After 10 years of intensive research and pre-clinical development, KT-110 has been accepted by the French regulatory agency for its first-in man phase II clinical trial by the end of 2018. This will be the main achievement of SMEi2020 project. Moreover all necessary actions for successful commercialisation to pharma companies (licensing deals) as well as continuous and updated IP & FTO issues are planned to be implemented during the SMEi2.
Through StopAddict project KT-110 will become the next leader of AUD treatment by generating 117€m of cumulative revenues between 2025-2027.
Our project will also allow to create more than 400 direct & indirect European jobs.
Today, the project is progressing. As many other organizations we suffered from the COVID 19 lock down which delayed our clinical trial by 6 months.
Patient recruitment is now completed and we expect results to be available by Feb 2022.
A new Once daily formulation will be ready in Q1/Q2 2022.
