Nature's cargo carriers may deliver preventative medicine across historically closed borders
Over the last few decades, a growing body of research suggests that chronic inflammation may be the common factor in numerous diseases. Aside from the obvious ones such as ulcerative colitis or rheumatoid arthritis, chronic inflammation has been linked to coronary artery disease, diabetes, cancer and Alzheimer's disease. Persistent DNA damage activates immune pathways leading to chronic inflammation and early onset neurodegeneration and metabolic disorders in mice. Current anti-inflammatory therapies also activate the immune system. The EU-funded InflaCare project is developing an exosome-based, non-immunogenic therapy that can even cross the blood-brain barrier, meaning its circulation in the blood could reach the brain and fight inflammation-related neurodegeneration. If successful, a simple systemic treatment could stall or stop the progress of many devastating diseases.
Fields of science
Funding SchemeERC-POC-LS - ERC Proof of Concept Lump Sum Pilot
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