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Advancing Tools for Human Early Lifecourse Exposome Research and Translation

Deliverables

Dissemination and engagement plan

This document will contain a guide on how to disseminate activities and outcomes in clear and accessible formats to reach the scientific, environmental health, urban and transport planning, clinical and public health community, and the general public.

Publication policy

This document will contain the publication policy for the whole project during the first year, agreed between all partners of the consortium. It will contain open access guidelines, authorship policy, and a pipeline to obtain the centralised funding for publications.

Data Management Plan

Co-lead ISGlobal and UMCG. This report will contain: 1) handling of research data during and after the end of the project, 2) what data will be collected, processed or generated, 3) which methodology and standards will be applied, 4) whether data will be shared/made open access and, 5) how data will be curated and preserved (including after the end of the project).

EXPOApp2

Co-lead Bettair and ISGlobal. This deliverable contains the App that study participants can install on their own phones for geolocalisation and physical activity data collection (task 2.3.1).

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Publications

Applying the exposome concept in birth cohort research: a review of statistical approaches

Author(s): Susana Santos, Léa Maitre, Charline Warembourg, Lydiane Agier, Lorenzo Richiardi, Xavier Basagaña, Martine Vrijheid
Published in: European Journal of Epidemiology, 35/3, 2020, Page(s) 193-204, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-020-00625-4

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort

Author(s): Chalana M. Sol, Charissa van Zwol - Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande, Susana Santos
Published in: Environmental Health, 20/1, 2021, ISSN 1476-069X
Publisher: BioMed Central
DOI: 10.1186/s12940-021-00747-6

Performance of approaches relying on multidimensional intermediary data to decipher causal relationships between the exposome and health: A simulation study under various causal structures

Author(s): Solène Cadiou, Xavier Basagaña, Juan R. Gonzalez, Johanna Lepeule, Martine Vrijheid, Valérie Siroux, Rémy Slama
Published in: Environment International, 153, 2021, Page(s) 106509, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106509

Privacy preserving data visualizations

Author(s): Demetris Avraam, Rebecca Wilson, Oliver Butters, Thomas Burton, Christos Nicolaides, Elinor Jones, Andy Boyd, Paul Burton
Published in: EPJ Data Science, 10/1, 2021, ISSN 2193-1127
Publisher: Springer
DOI: 10.1140/epjds/s13688-020-00257-4

The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma

Author(s): Alicia Guillien, Solène Cadiou, Rémy Slama, Valérie Siroux
Published in: International Journal of Environmental Research and Public Health, 18/3, 2021, Page(s) 1138, ISSN 1660-4601
Publisher: MDPI
DOI: 10.3390/ijerph18031138

Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study

Author(s): Chalana M. Sol, Susana Santos, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Liesbeth Duijts, Kurunthachalam Kannan, Leonardo Trasande, Vincent W.V. Jaddoe
Published in: Environment International, 138, 2020, Page(s) 105677, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.105677

Orchestrating privacy-protected big data analyses of data from different resources with R and DataSHIELD

Author(s): Yannick Marcon, Tom Bishop, Demetris Avraam, Xavier Escriba-Montagut, Patricia Ryser-Welch, Stuart Wheater, Paul Burton, Juan R. González
Published in: PLOS Computational Biology, 17/3, 2021, Page(s) e1008880, ISSN 1553-7358
Publisher: PLOS
DOI: 10.1371/journal.pcbi.1008880

Variability of multi-omics profiles in a population-based child cohort

Author(s): Marta Gallego-Paüls, Carles Hernández-Ferrer, Mariona Bustamante, Xavier Basagaña, Jose Barrera-Gómez, Chung-Ho E. Lau, Alexandros P. Siskos, Marta Vives-Usano, Carlos Ruiz-Arenas, John Wright, Remy Slama, Barbara Heude, Maribel Casas, Regina Grazuleviciene, Leda Chatzi, Eva Borràs, Eduard Sabidó, Ángel Carracedo, Xavier Estivill, Jose Urquiza, Muireann Coen, Hector C. Keun, Juan R. Gonzál
Published in: BMC Medicine, 19/1, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-021-02027-z

The early-life exposome and epigenetic age acceleration in children

Author(s): Paula de Prado-Bert, Carlos Ruiz-Arenas, Marta Vives-Usano, Sandra Andrusaityte, Solène Cadiou, Ángel Carracedo, Maribel Casas, Leda Chatzi, Payam Dadvand, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Line S. Haug, Carles Hernandez-Ferrer, Hector C. Keun, Johanna Lepeule, Léa Maitre, Rosie McEachan, Mark J. Nieuwenhuijsen, Dolors Pelegrí, Oliver Robinson, Rémy Slama, Marina
Published in: Environment International, 155, 2021, Page(s) 106683, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106683

Fetal phthalates and bisphenols and childhood lipid and glucose metabolism. A population-based prospective cohort study

Author(s): Chalana M. Sol, Susana Santos, Liesbeth Duijts, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe, Leonardo Trasande
Published in: Environment International, 144, 2020, Page(s) 106063, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106063

Urinary metabolite quantitative trait loci in children and their interaction with dietary factors

Author(s): Beatriz Calvo-Serra, Léa Maitre, Chung-Ho E Lau, Alexandros P Siskos, Kristine B Gützkow, Sandra Andrušaitytė, Maribel Casas, Solène Cadiou, Leda Chatzi, Juan R González, Regina Grazuleviciene, Rosemary McEachan, Rémy Slama, Marina Vafeiadi, John Wright, Murieann Coen, Martine Vrijheid, Hector C Keun, Geòrgia Escaramís, Mariona Bustamante
Published in: Human Molecular Genetics, 29/23, 2020, Page(s) 3830-3844, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaa257

Fetal exposure to phthalates and bisphenols and childhood general and organ fat. A population-based prospective cohort study

Author(s): Chalana M. Sol, Susana Santos, Liesbeth Duijts, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Elise M. Philips, Leonardo Trasande, Vincent W. V. Jaddoe
Published in: International Journal of Obesity, 44/11, 2020, Page(s) 2225-2235, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-020-00672-7

Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study

Author(s): Susana Santos, Chalana M. Sol, Charissa van Zwol – Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W.V. Jaddoe, Leonardo Trasande
Published in: Environment International, 151, 2021, Page(s) 106443, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2021.106443

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children

Author(s): Nikos Stratakis, David V. Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F. Farzan, Serena Fossati, Juan R. Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R. C. McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Br
Published in: JAMA Network Open, 3/3, 2020, Page(s) e201007, ISSN 2574-3805
Publisher: Americal Medical Association
DOI: 10.1001/jamanetworkopen.2020.1007

In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children

Author(s): Marta Vives-Usano, Carles Hernandez-Ferrer, Léa Maitre, Carlos Ruiz-Arenas, Sandra Andrusaityte, Eva Borràs, Ángel Carracedo, Maribel Casas, Leda Chatzi, Muireann Coen, Xavier Estivill, Juan R. González, Regina Grazuleviciene, Kristine B. Gutzkow, Hector C. Keun, Chung-Ho E. Lau, Solène Cadiou, Johanna Lepeule, Dan Mason, Inés Quintela, Oliver Robinson, Eduard Sabidó, Gillian Santorelli, Pe
Published in: BMC Medicine, 18/1, 2020, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-020-01686-8