Brain injury in the premature born infant: stem cell regeneration research network

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Publications

Umbilical cord-mesenchymal stem cells induce a memory phenotype in CD4+ T cells.

Author(s): Sengun E, Wolfs TGAM, van Bruggen VLE, van Cranenbroek B, Simonetti ER, Ophelders D, de Jonge MI, Joosten I, van der Molen RG.
Published in: Frontiers Immunology, Issue Volume 14 - 2023, 2023, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2023.1128359

A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity

Author(s): Klein L.; Van Steenwinckel J.; Fleiss B.; Scheuer T.; Bührer C.; Faivre V.; Bokobza C.; Lemoine S.; Blugeon C..; Schwendimann L.; Csaba Z.; Vousden D.; Lerch J.; Vernon A.; Gressens P.; Schmitz T
Published in: Glia, 2022, Page(s) 1699-1719, ISSN 1098-1136
Publisher: Wiley
DOI: 10.1002/glia.24190

The multiple faces of extracellular vesicles released by microglia: Where are we 10 years after?

Author(s): Martina Gabrielli, Stefano Raffaele, Marta Fumagalli and Claudia Verderio
Published in: Frontiers in Cellular Neurosciences, 2022, Page(s) pages 01-29, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.984690

Preterm birth: A neuroinflammatory origin for metabolic diseases?

Author(s): Sihao Diao, Chao Chen, Alexandre Benani, Christophe Magnan, Juliette Van Steenwinckel, Pierre Gressens, Céline Cruciani-Guglielmacci, Alice Jacquens, Cindy Bokobza
Published in: Brain, Behavior, & Immunity - Health, Issue 37, 2024, Page(s) 100745, ISSN 2666-3546
Publisher: ELSEVIER
DOI: 10.1016/j.bbih.2024.100745

Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders

Author(s): Bobbi Fleiss, Pierre Gressens, Helen B. Stolp
Published in: Frontiers in Neurology, Issue 11, 2020, Page(s) 1-21, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.00575

Induction of Mitochondrial Fragmentation and Mitophagy after Neonatal Hypoxia-Ischemia

Author(s): Syam Nair, Anna-Lena Leverin, Eridan Rocha-Ferreira, Kristina S Sobotka, Claire Thornton, Carina Mallard, Henrik Hagberg.
Published in: Cells, 2022, Page(s) 1193, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11071193

Therapeutic potential of stem cells for preterm infant brain damage: Can we move from the heterogeneity of preclinical and clinical studies to established therapeutics?

Author(s): Sofia Passera, Marta Boccazzi, Cindy Bokobza, Valerie Faivre, Fabio Mosca, Juliette Van Steenwinckel, Monica Fumagalli, Pierre Gressens, Bobbi Fleiss
Published in: Biochemical Pharmacology, Issue 186, 2021, Page(s) 114461, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2021.114461

No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study

Author(s): Mads Andersen, Hannah Brogård Andersen, Ted Carl Kejlberg Andelius, Lærke Hjøllund Hansen, Regitze Pinnerup, Mette Bjerre, Steffen Ringgaard, Leslie Schwendimann, Pierre Gressens, Kasper Jacobsen Kyng, Tine Brink Henriksen
Published in: Frontiers in Pediatrics, Issue 11, 2023, ISSN 2296-2360
Publisher: Frontiers in Pediatric
DOI: 10.3389/fped.2023.1268237

miR-146b Protects the Perinatal Brain against Microglia-Induced Hypomyelination

Author(s): Bokobza C.; Joshi P.; Schang AL.; Csaba Z.; Faivre V.; Montané A.; Galland A.; Benmamar-Badel A.; Bosher E.; Lebon S.; Schwendimann L.; Mani S.; Dournaud P.; Besson V.; Fleiss B.; Gressens P.; Van Steenwinckel J.
Published in: Annals of Neurology, 2021, Page(s) 48-65, ISSN 1531-8249
Publisher: Wiley
DOI: 10.1002/ana.26263

Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder

Author(s): Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verlo
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-41869-4

Key roles of glial cells in the encephalopathy of prematurity

Author(s): Juliette Van Steenwinckel, Cindy Bokobza, Mireille Laforge, Isabelle K. Shearer, Veronique E. Miron, Rejane Rua, Samantha M. Matta, Elisa L. Hill‐Yardin, Bobbi Fleiss, Pierre Gressens
Published in: Glia, Issue 72, 2024, Page(s) 475-503, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.24474

A Neonatal Rodent Model of Retroorbital Vein Injection

Author(s): Eridan Rocha-Ferreira1, Syam Nair1, Owen Herrock1, Erik Axel Andersson2, Carl Joakim Ek2, Carina Mallard2, Henrik Hagberg1
Published in: Jove journal, Issue JOVE, 2024, Page(s) 1-8, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/65386

Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity

Author(s): M.J.V. Brandt, C.M. Kosmeijer, E.J.M. Achterberg, C.G.M. de Theije, C.H.A. Nijboer
Published in: Brain, Behavior, & Immunity - Health, 2024, ISSN 2666-3546
Publisher: Elsevier Inc.
DOI: 10.1016/j.bbih.2024.100817

Deleterious effect of sustained neuroinflammation in pediatric traumatic brain injury

Author(s): Alice Jacquens, Zsolt Csaba, Haleh Soleimanzad, Cindy Bokobza, Pierre-Romain Delmotte, Caroline Userovici, Pierre Boussemart, Vibol Chhor, Damien Bouvier, Yohan van de Looij, Valérie Faivre, Siaho Diao, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Pierrette Young-Ten, Vanessa Naffaa, Olivier Laprevote, Mickael Tanter, Pascal Dournaud, Juliette Van Steenwinckel, Vincent Degos, Pierre Gres
Published in: Brain, Behavior, and Immunity, Issue 120, 2024, Page(s) 99-116, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2024.04.029

The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

Author(s): Marta Boccazzi, Juliette Van Steenwinckel, Anne-Laure Schang, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Zsolt Csaba, Claudia Verderio, Marta Fumagalli, Shyamala Mani, Pierre Gressens
Published in: Cell Death & Disease, Issue 12/2, 2021, Page(s) 1-12, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03446-9

High sensitivity mapping of brain-wide functional networks in awake mice using simultaneous multi-slice fUS imaging

Author(s): Adrien Bertolo, Jeremy Ferrier, Silvia Cazzanelli, Samuel Diebolt, Mickael Tanter, Sophie Pezet, Mathieu Pernot, Bruno-Félix Osmanski, Thomas Deffieux
Published in: Imaging Neuroscience, Issue 1, 2023, Page(s) 1-18, ISSN 2837-6056
Publisher: Imaging Neuroscience
DOI: 10.1162/imag_a_00030

The Impact of Mouse Preterm Birth Induction by RU-486 on Microglial Activation and Subsequent Hypomyelination

Author(s): Morin C.; Guenoun D.; Faivre V.; Sautet I.; Schwendimann L.; Young-Ten P.; Gressens P.; Van Steenwinckel J.; Bokobza C.
Published in: IJMS, 2022, Page(s) 4867, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23094867

G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation

Author(s): Marta Boccazzi, Giulia Macchiarulo, Sophie Lebon, Justyna Janowska, Tifenn Le Charpentier, Valérie Faivre, Jennifer Hua, Davide Marangon, Davide Lecca, Marta Fumagalli, Shyamala Mani, Maria P. Abbracchio, Pierre Gressens, Anne-Laure Schang, Juliette Van Steenwinckel
Published in: Neurobiology of Disease, Issue 187, 2024, Page(s) 106315, ISSN 0969-9961
Publisher: Academic Press
DOI: 10.1016/j.nbd.2023.106315

Preterm Birth by Cesarean Section: The Gut-Brain Axis, a Key Regulator of Brain Development

Author(s): Cécile Morin, Cindy Bokobza, Bobbi Fleiss, Elisa L. Hill-Yardin, Juliette Van Steenwinckel, Pierre Gressens
Published in: Developmental Neuroscience, Issue 46, 2024, Page(s) 179-187, ISSN 0378-5866
Publisher: S. Karger AG
DOI: 10.1159/000534124

Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study

Author(s): Aoife Branagan, Tim Hurley, Fiona Quirke, Declan Devane, Petek E. Taneri, Nadia Badawi, Bharati Sinha, Cynthia Bearer, Frank H. Bloomfield, Sonia L. Bonifacio, Geraldine Boylan, Suzann K. Campbell, Lina Chalak, Mary D’Alton, Linda S. deVries, Mohamed El Dib, Donna M. Ferriero, Chris Gale, Pierre Gressens, Alistair J. Gunn, Sarah Kay, Beccy Maeso, Sarah B. Mulkey, Deirdre M. Murray, Karin B. Nels
Published in: Pediatric Research, 2024, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-024-03303-3

Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries

Author(s): Bobbi Fleiss, Juliette Van Steenwinckel, Cindy Bokobza, Isabelle K. Shearer, Emily Ross-Munro, Pierre Gressens
Published in: Biomolecules, Issue 11/1, 2021, Page(s) 99, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11010099

A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups

Author(s): Masako Jinnai, Gabriella Koning, Gagandeep Singh-Mallah, Andrea Jonsdotter, Anna-Lena Leverin, Pernilla Svedin, Syam Nair, Satoru Takeda, Xiaoyang Wang, Carina Mallard, Carl Joakim Ek, Eridan Rocha-Ferreira, Henrik Hagberg
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.535320

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Author(s): Daan R.M.G. Ophelders, Ruth Gussenhoven, Luise Klein, Reint K. Jellema, Rob J.J. Westerlaken, Matthias C. Hütten, Jeroen Vermeulen, Guido Wassink, Alistair J. Gunn, Tim G.A.M. Wolfs
Published in: Cells, Issue 9/8, 2020, Page(s) 1871, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9081871

Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation, and reactive oxygen species

Author(s): Syam Nair, Eridan Rocha‐Ferreira, Bobbi Fleiss, Cora H Nijboer, Pierre Gressens, Carina Mallard, Henrik Hagberg
Published in: Journal of Neurochemistry, Issue 158/1, 2021, Page(s) 59-73, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15267

Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder

Author(s): Camille M. Hours, Sophie Gil, Pierre Gressens
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 15139, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015139

Neonatal encephalopathy and hypoxic–ischemic encephalopathy: moving from controversy to consensus definitions and subclassification

Author(s): Eleanor J. Molloy, Aoife Branagan, Tim Hurley, Fiona Quirke, Declan Devane, Petek E. Taneri, Mohamed El-Dib, Frank H. Bloomfield, Beccy Maeso, Betsy Pilon, Sonia L. Bonifacio, Courtney J. Wusthoff, Lina Chalak, Cynthia Bearer, Deirdre M. Murray, Nadia Badawi, Suzann Campbell, Sarah Mulkey, Pierre Gressens, Donna M. Ferriero, Linda S. de Vries, Karen Walker, Sarah Kay, Geraldine Boylan, Chris Gale,
Published in: Pediatric Research, Issue 94, 2023, Page(s) 1860-1863, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-023-02775-z

Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries

Author(s): Bokobza C.*; Jacquens A.*; Guenoun D. ; Bianco B. ; Galland A. ; Pispisa M. ; Cruz A.; Zinni M. ; Faivre V.; Roumier A.; Lebon S.; Vitalis T.; Csaba Z.; Le Charpentier T.; Schwendimann L.; Young-Ten P.; Degos V. ; Monteiro P.; Dournaud P.; Gressens P.; Van Steenwinckel J.
Published in: Journal of Neurotransmission, 2022, ISSN 2213-7793
Publisher: Springer
DOI: 10.1007/s00702-022-02556-8

Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus

Author(s): Francesca Bertino, Dibyanti Mukherjee, Massimo Bonora, Christoph Bagowski, Jeannette Nardelli, Livia Metani, Diletta Isabella Zanin Venturini, Diego Chianese, Nicolas Santander, Iris Chiara Salaroglio, Andreas Hentschel, Elisa Quarta, Tullio Genova, Arpana Arjun McKinney, Anna Lucia Allocco, Veronica Fiorito, Sara Petrillo, Giorgia Ammirata, Francesco De Giorgio, Evan Dennis, Garrett Allington, Fe
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101647, ISSN 2666-3791
Publisher: Cell Report Medicine
DOI: 10.1016/j.xcrm.2024.101647

Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor

Author(s): Hélène Cwerman-Thibault, Vassilissa Malko-Baverel, Gwendoline Le Guilloux, Isabel Torres-Cuevas, Edward Ratcliffe, Djmila Mouri, Virginie Mignon, Bruno Saubaméa, Odile Boespflug-Tanguy, Pierre Gressens, Marisol Corral-Debrinski
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Issue 1870, 2024, Page(s) 167272, ISSN 0925-4439
Publisher: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167272

Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior

Author(s): Hélène Cwerman-Thibault, Vassilissa Malko-Baverel, Gwendoline Le Guilloux, Edward Ratcliffe, Djmila Mouri, Isabel Torres-Cuevas, Ivan Millán, Bruno Saubaméa, Virginie Mignon, Odile Boespflug-Tanguy, Pierre Gressens, Marisol Corral-Debrinski
Published in: Molecular Therapy, Issue 32, 2024, Page(s) 2150-2175, ISSN 1525-0016
Publisher: Nature Publishing Group
DOI: 10.1016/j.ymthe.2024.05.030

Therapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia

Author(s): Daniel Alonso-Alconada, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Published in: Pediatric Research, Issue 95, 2024, Page(s) 112-119, ISSN 0031-3998
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-023-02751-7

Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis

Author(s): Yoann Vial, Jeannette Nardelli, Adeline A Bonnard, Justine Rousselot, Michèle Souyri, Pierre Gressens, Hélène Cavé, Séverine Drunat
Published in: EMBO Reports, Issue 25, 2024, Page(s) 2418-2440, ISSN 1469-3178
Publisher: EMBO Press
DOI: 10.1038/s44319-024-00123-8

Consequences of General Anesthesia in Infancy on Behavior and Brain Structure

Author(s): Jean-Philippe Salaün, Audrey Chagnot, Arnaud Cachia, Nicolas Poirel, Valérie Datin-Dorrière, Cléo Dujarrier, Eloïse Lemarchand, Marine Rolland, Lisa Delalande, Pierre Gressens, Bernard Guillois, Olivier Houdé, Damien Levard, Clément Gakuba, Marine Moyon, Mikael Naveau, François Orliac, Gilles Orliaguet, Jean-Luc Hanouz, Véronique Agin, Grégoire Borst, Denis Vivien
Published in: Anesthesia & Analgesia, Issue 136, 2023, Page(s) 240-250, ISSN 0003-2999
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1213/ane.0000000000006233

Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury

Author(s): Nicole Labusek 1, Parnian Ghari 1, Yanis Mouloud 2, Christian Köster 1, Eva Diesterbeck 1, Martin Hadamitzky 3, Ursula Felderhoff-Müser 1, Ivo Bendix 1, Bernd Giebel 2, Josephine Herz 4
Published in: National Library of Medicine, 2023, Page(s) 20(1):280, ISSN 1742-2094
Publisher: BioMed Central
DOI: 10.1186/s12974-023-02961-0

Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury

Author(s): Flora Faure, Jérôme Baranger, Marianne Alison, Béatrice Boutillier, Alice Frérot, Chung Lim, Grégory Planchette, Mickael Prigent, Mickaël Tanter, Olivier Baud, Valérie Biran, Charlie Demené
Published in: Journal of Cerebral Blood Flow & Metabolism, 2024, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x241232197

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Injury

Author(s): Nicole Kaminski, Christian Köster, Yanis Mouloud, Verena Börger, Ursula Felderhoff-Müser , Ivo Bendix, Bernd Giebel and Josephine Herz
Published in: Frontiers in Cellular Neurosciences, 2020, Page(s) Vol. 14, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.601176

Neurodevelopmental disorders: research and interventions beyond classifications

Author(s): Paul Olivier, Pierre Gressens, Catherine Barthelemy
Published in: Journal of Neural Transmission, Issue 130, 2023, Page(s) 181-184, ISSN 0300-9564
Publisher: Springer Verlag
DOI: 10.1007/s00702-023-02596-8

Ultrasound multiparametric imaging of neuroinflammation

Author(s): Ruinet S, Soleimanzad H, Csaba Z, Ialy-Radio N, Bokobza C, Gressens P, Tanter M
Published in: 2022
Publisher: Society for Neuroscience

Magnetic Isolation of Microglial Cells from Neonate Mouse for Primary Cell Cultures

Author(s): Bokobza C.*; Jacquens A.* ; Zinni M. ; Faivre V.; Hua J. ; Guenoun D. ; Userovici C. ; Mani S.; Degos V. ; Gressens P.; Van Steenwinckel J.
Published in: JOVE, 2022, Page(s) 185, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62964

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