Brain injury in the premature born infant: stem cell regeneration research network

Project Information

PREMSTEM

Grant agreement ID: 874721

DOI 10.3030/874721

EC signature date 6 December 2019

Start date 1 January 2020

End date 31 December 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 10 708 285,00

EU contribution € 8 999 620,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Deliverables

Documents, reports (1)

Interim report on content elements

Publications

Peer reviewed articles (14)

A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity

Author(s): Klein L.; Van Steenwinckel J.; Fleiss B.; Scheuer T.; Bührer C.; Faivre V.; Bokobza C.; Lemoine S.; Blugeon C..; Schwendimann L.; Csaba Z.; Vousden D.; Lerch J.; Vernon A.; Gressens P.; Schmitz T
Published in: Glia, 2022, Page(s) 1699-1719, ISSN 1098-1136
Publisher: Wiley
DOI: 10.1002/glia.24190

The multiple faces of extracellular vesicles released by microglia: Where are we 10 years after?

Author(s): Martina Gabrielli, Stefano Raffaele, Marta Fumagalli and Claudia Verderio
Published in: Frontiers in Cellular Neurosciences, 2022, Page(s) pages 01-29, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.984690

Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders

Author(s): Bobbi Fleiss, Pierre Gressens, Helen B. Stolp
Published in: Frontiers in Neurology, Issue 11, 2020, Page(s) 1-21, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.00575

Induction of Mitochondrial Fragmentation and Mitophagy after Neonatal Hypoxia-Ischemia

Author(s): Syam Nair, Anna-Lena Leverin, Eridan Rocha-Ferreira, Kristina S Sobotka, Claire Thornton, Carina Mallard, Henrik Hagberg.
Published in: Cells, 2022, Page(s) 1193, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11071193

Therapeutic potential of stem cells for preterm infant brain damage: Can we move from the heterogeneity of preclinical and clinical studies to established therapeutics?

Author(s): Sofia Passera, Marta Boccazzi, Cindy Bokobza, Valerie Faivre, Fabio Mosca, Juliette Van Steenwinckel, Monica Fumagalli, Pierre Gressens, Bobbi Fleiss
Published in: Biochemical Pharmacology, Issue 186, 2021, Page(s) 114461, ISSN 0006-2952
Publisher: Elsevier BV
DOI: 10.1016/j.bcp.2021.114461

miR-146b Protects the Perinatal Brain against Microglia-Induced Hypomyelination

Author(s): Bokobza C.; Joshi P.; Schang AL.; Csaba Z.; Faivre V.; Montané A.; Galland A.; Benmamar-Badel A.; Bosher E.; Lebon S.; Schwendimann L.; Mani S.; Dournaud P.; Besson V.; Fleiss B.; Gressens P.; Van Steenwinckel J.
Published in: Annals of Neurology, 2021, Page(s) 48-65, ISSN 1531-8249
Publisher: Wiley
DOI: 10.1002/ana.26263

The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

Author(s): Marta Boccazzi, Juliette Van Steenwinckel, Anne-Laure Schang, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Zsolt Csaba, Claudia Verderio, Marta Fumagalli, Shyamala Mani, Pierre Gressens
Published in: Cell Death & Disease, Issue 12/2, 2021, Page(s) 1-12, ISSN 2041-4889
Publisher: Nature Publishing Group
DOI: 10.1038/s41419-021-03446-9

The Impact of Mouse Preterm Birth Induction by RU-486 on Microglial Activation and Subsequent Hypomyelination

Author(s): Morin C.; Guenoun D.; Faivre V.; Sautet I.; Schwendimann L.; Young-Ten P.; Gressens P.; Van Steenwinckel J.; Bokobza C.
Published in: IJMS, 2022, Page(s) 4867, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23094867

Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries

Author(s): Bobbi Fleiss, Juliette Van Steenwinckel, Cindy Bokobza, Isabelle K. Shearer, Emily Ross-Munro, Pierre Gressens
Published in: Biomolecules, Issue 11/1, 2021, Page(s) 99, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom11010099

A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups

Author(s): Masako Jinnai, Gabriella Koning, Gagandeep Singh-Mallah, Andrea Jonsdotter, Anna-Lena Leverin, Pernilla Svedin, Syam Nair, Satoru Takeda, Xiaoyang Wang, Carina Mallard, Carl Joakim Ek, Eridan Rocha-Ferreira, Henrik Hagberg
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.535320

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Author(s): Daan R.M.G. Ophelders, Ruth Gussenhoven, Luise Klein, Reint K. Jellema, Rob J.J. Westerlaken, Matthias C. Hütten, Jeroen Vermeulen, Guido Wassink, Alistair J. Gunn, Tim G.A.M. Wolfs
Published in: Cells, Issue 9/8, 2020, Page(s) 1871, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells9081871

Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation, and reactive oxygen species

Author(s): Syam Nair, Eridan Rocha‐Ferreira, Bobbi Fleiss, Cora H Nijboer, Pierre Gressens, Carina Mallard, Henrik Hagberg
Published in: Journal of Neurochemistry, Issue 158/1, 2021, Page(s) 59-73, ISSN 0022-3042
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15267

Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries

Author(s): Bokobza C.*; Jacquens A.*; Guenoun D. ; Bianco B. ; Galland A. ; Pispisa M. ; Cruz A.; Zinni M. ; Faivre V.; Roumier A.; Lebon S.; Vitalis T.; Csaba Z.; Le Charpentier T.; Schwendimann L.; Young-Ten P.; Degos V. ; Monteiro P.; Dournaud P.; Gressens P.; Van Steenwinckel J.
Published in: Journal of Neurotransmission, 2022, ISSN 2213-7793
Publisher: Springer
DOI: 10.1007/s00702-022-02556-8

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Injury

Author(s): Nicole Kaminski, Christian Köster, Yanis Mouloud, Verena Börger, Ursula Felderhoff-Müser , Ivo Bendix, Bernd Giebel and Josephine Herz
Published in: Frontiers in Cellular Neurosciences, 2020, Page(s) Vol. 14, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.601176

Conference proceedings (1)

Ultrasound multiparametric imaging of neuroinflammation

Author(s): Ruinet S, Soleimanzad H, Csaba Z, Ialy-Radio N, Bokobza C, Gressens P, Tanter M
Published in: 2022
Publisher: Society for Neuroscience

Non-peer reviewed articles (1)

Magnetic Isolation of Microglial Cells from Neonate Mouse for Primary Cell Cultures

Author(s): Bokobza C.*; Jacquens A.* ; Zinni M. ; Faivre V.; Hua J. ; Guenoun D. ; Userovici C. ; Mani S.; Degos V. ; Gressens P.; Van Steenwinckel J.
Published in: JOVE, 2022, Page(s) 185, ISSN 1940-087X
Publisher: MYJoVE Corporation
DOI: 10.3791/62964