Brain injury in the premature born infant: stem cell regeneration research network

Información del proyecto

PREMSTEM

Identificador del acuerdo de subvención: 874721

DOI

10.3030/874721

Fecha de la firma de la CE 6 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 10 708 285,00

Aportación de la UE

€ 8 999 620,00

Coordinado por

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

Interim report on content elements
Open Innovation activities: Co-Creation Sessions

Publicaciones

Peer reviewed articles (37)

Umbilical cord-mesenchymal stem cells induce a memory phenotype in CD4+ T cells.

Autores: Sengun E, Wolfs TGAM, van Bruggen VLE, van Cranenbroek B, Simonetti ER, Ophelders D, de Jonge MI, Joosten I, van der Molen RG.
Publicado en: Frontiers Immunology, Edición Volume 14 - 2023, 2023, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2023.1128359

A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematurity

Autores: Klein L.; Van Steenwinckel J.; Fleiss B.; Scheuer T.; Bührer C.; Faivre V.; Bokobza C.; Lemoine S.; Blugeon C..; Schwendimann L.; Csaba Z.; Vousden D.; Lerch J.; Vernon A.; Gressens P.; Schmitz T
Publicado en: Glia, 2022, Página(s) 1699-1719, ISSN 1098-1136
Editor: Wiley
DOI: 10.1002/glia.24190

The multiple faces of extracellular vesicles released by microglia: Where are we 10 years after?

Autores: Martina Gabrielli, Stefano Raffaele, Marta Fumagalli and Claudia Verderio
Publicado en: Frontiers in Cellular Neurosciences, 2022, Página(s) pages 01-29, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2022.984690

Preterm birth: A neuroinflammatory origin for metabolic diseases?

Autores: Sihao Diao, Chao Chen, Alexandre Benani, Christophe Magnan, Juliette Van Steenwinckel, Pierre Gressens, Céline Cruciani-Guglielmacci, Alice Jacquens, Cindy Bokobza
Publicado en: Brain, Behavior, & Immunity - Health, Edición 37, 2024, Página(s) 100745, ISSN 2666-3546
Editor: ELSEVIER
DOI: 10.1016/j.bbih.2024.100745

Cortical Gray Matter Injury in Encephalopathy of Prematurity: Link to Neurodevelopmental Disorders

Autores: Bobbi Fleiss, Pierre Gressens, Helen B. Stolp
Publicado en: Frontiers in Neurology, Edición 11, 2020, Página(s) 1-21, ISSN 1664-2295
Editor: Frontiers Research Foundation
DOI: 10.3389/fneur.2020.00575

Induction of Mitochondrial Fragmentation and Mitophagy after Neonatal Hypoxia-Ischemia

Autores: Syam Nair, Anna-Lena Leverin, Eridan Rocha-Ferreira, Kristina S Sobotka, Claire Thornton, Carina Mallard, Henrik Hagberg.
Publicado en: Cells, 2022, Página(s) 1193, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11071193

Therapeutic potential of stem cells for preterm infant brain damage: Can we move from the heterogeneity of preclinical and clinical studies to established therapeutics?

Autores: Sofia Passera, Marta Boccazzi, Cindy Bokobza, Valerie Faivre, Fabio Mosca, Juliette Van Steenwinckel, Monica Fumagalli, Pierre Gressens, Bobbi Fleiss
Publicado en: Biochemical Pharmacology, Edición 186, 2021, Página(s) 114461, ISSN 0006-2952
Editor: Elsevier BV
DOI: 10.1016/j.bcp.2021.114461

No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study

Autores: Mads Andersen, Hannah Brogård Andersen, Ted Carl Kejlberg Andelius, Lærke Hjøllund Hansen, Regitze Pinnerup, Mette Bjerre, Steffen Ringgaard, Leslie Schwendimann, Pierre Gressens, Kasper Jacobsen Kyng, Tine Brink Henriksen
Publicado en: Frontiers in Pediatrics, Edición 11, 2023, ISSN 2296-2360
Editor: Frontiers in Pediatric
DOI: 10.3389/fped.2023.1268237

miR-146b Protects the Perinatal Brain against Microglia-Induced Hypomyelination

Autores: Bokobza C.; Joshi P.; Schang AL.; Csaba Z.; Faivre V.; Montané A.; Galland A.; Benmamar-Badel A.; Bosher E.; Lebon S.; Schwendimann L.; Mani S.; Dournaud P.; Besson V.; Fleiss B.; Gressens P.; Van Steenwinckel J.
Publicado en: Annals of Neurology, 2021, Página(s) 48-65, ISSN 1531-8249
Editor: Wiley
DOI: 10.1002/ana.26263

Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder

Autores: Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verlo
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-41869-4

Key roles of glial cells in the encephalopathy of prematurity

Autores: Juliette Van Steenwinckel, Cindy Bokobza, Mireille Laforge, Isabelle K. Shearer, Veronique E. Miron, Rejane Rua, Samantha M. Matta, Elisa L. Hill‐Yardin, Bobbi Fleiss, Pierre Gressens
Publicado en: Glia, Edición 72, 2024, Página(s) 475-503, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.24474

A Neonatal Rodent Model of Retroorbital Vein Injection

Autores: Eridan Rocha-Ferreira1, Syam Nair1, Owen Herrock1, Erik Axel Andersson2, Carl Joakim Ek2, Carina Mallard2, Henrik Hagberg1
Publicado en: Jove journal, Edición JOVE, 2024, Página(s) 1-8, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/65386

Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity

Autores: M.J.V. Brandt, C.M. Kosmeijer, E.J.M. Achterberg, C.G.M. de Theije, C.H.A. Nijboer
Publicado en: Brain, Behavior, & Immunity - Health, 2024, ISSN 2666-3546
Editor: Elsevier Inc.
DOI: 10.1016/j.bbih.2024.100817

Deleterious effect of sustained neuroinflammation in pediatric traumatic brain injury

Autores: Alice Jacquens, Zsolt Csaba, Haleh Soleimanzad, Cindy Bokobza, Pierre-Romain Delmotte, Caroline Userovici, Pierre Boussemart, Vibol Chhor, Damien Bouvier, Yohan van de Looij, Valérie Faivre, Siaho Diao, Sophie Lemoine, Corinne Blugeon, Leslie Schwendimann, Pierrette Young-Ten, Vanessa Naffaa, Olivier Laprevote, Mickael Tanter, Pascal Dournaud, Juliette Van Steenwinckel, Vincent Degos, Pierre Gres
Publicado en: Brain, Behavior, and Immunity, Edición 120, 2024, Página(s) 99-116, ISSN 0889-1591
Editor: Academic Press
DOI: 10.1016/j.bbi.2024.04.029

The immune-inflammatory response of oligodendrocytes in a murine model of preterm white matter injury: the role of TLR3 activation

Autores: Marta Boccazzi, Juliette Van Steenwinckel, Anne-Laure Schang, Valérie Faivre, Tifenn Le Charpentier, Cindy Bokobza, Zsolt Csaba, Claudia Verderio, Marta Fumagalli, Shyamala Mani, Pierre Gressens
Publicado en: Cell Death & Disease, Edición 12/2, 2021, Página(s) 1-12, ISSN 2041-4889
Editor: Nature Publishing Group
DOI: 10.1038/s41419-021-03446-9

High sensitivity mapping of brain-wide functional networks in awake mice using simultaneous multi-slice fUS imaging

Autores: Adrien Bertolo, Jeremy Ferrier, Silvia Cazzanelli, Samuel Diebolt, Mickael Tanter, Sophie Pezet, Mathieu Pernot, Bruno-Félix Osmanski, Thomas Deffieux
Publicado en: Imaging Neuroscience, Edición 1, 2023, Página(s) 1-18, ISSN 2837-6056
Editor: Imaging Neuroscience
DOI: 10.1162/imag_a_00030

The Impact of Mouse Preterm Birth Induction by RU-486 on Microglial Activation and Subsequent Hypomyelination

Autores: Morin C.; Guenoun D.; Faivre V.; Sautet I.; Schwendimann L.; Young-Ten P.; Gressens P.; Van Steenwinckel J.; Bokobza C.
Publicado en: IJMS, 2022, Página(s) 4867, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23094867

G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation

Autores: Marta Boccazzi, Giulia Macchiarulo, Sophie Lebon, Justyna Janowska, Tifenn Le Charpentier, Valérie Faivre, Jennifer Hua, Davide Marangon, Davide Lecca, Marta Fumagalli, Shyamala Mani, Maria P. Abbracchio, Pierre Gressens, Anne-Laure Schang, Juliette Van Steenwinckel
Publicado en: Neurobiology of Disease, Edición 187, 2024, Página(s) 106315, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2023.106315

Preterm Birth by Cesarean Section: The Gut-Brain Axis, a Key Regulator of Brain Development

Autores: Cécile Morin, Cindy Bokobza, Bobbi Fleiss, Elisa L. Hill-Yardin, Juliette Van Steenwinckel, Pierre Gressens
Publicado en: Developmental Neuroscience, Edición 46, 2024, Página(s) 179-187, ISSN 0378-5866
Editor: S. Karger AG
DOI: 10.1159/000534124

Consensus definition and diagnostic criteria for neonatal encephalopathy—study protocol for a real-time modified delphi study

Autores: Aoife Branagan, Tim Hurley, Fiona Quirke, Declan Devane, Petek E. Taneri, Nadia Badawi, Bharati Sinha, Cynthia Bearer, Frank H. Bloomfield, Sonia L. Bonifacio, Geraldine Boylan, Suzann K. Campbell, Lina Chalak, Mary D’Alton, Linda S. deVries, Mohamed El Dib, Donna M. Ferriero, Chris Gale, Pierre Gressens, Alistair J. Gunn, Sarah Kay, Beccy Maeso, Sarah B. Mulkey, Deirdre M. Murray, Karin B. Nels
Publicado en: Pediatric Research, 2024, ISSN 0031-3998
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-024-03303-3

Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries

Autores: Bobbi Fleiss, Juliette Van Steenwinckel, Cindy Bokobza, Isabelle K. Shearer, Emily Ross-Munro, Pierre Gressens
Publicado en: Biomolecules, Edición 11/1, 2021, Página(s) 99, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom11010099

A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups

Autores: Masako Jinnai, Gabriella Koning, Gagandeep Singh-Mallah, Andrea Jonsdotter, Anna-Lena Leverin, Pernilla Svedin, Syam Nair, Satoru Takeda, Xiaoyang Wang, Carina Mallard, Carl Joakim Ek, Eridan Rocha-Ferreira, Henrik Hagberg
Publicado en: Frontiers in Cellular Neuroscience, Edición 14, 2020, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.535320

Preterm Brain Injury, Antenatal Triggers, and Therapeutics: Timing Is Key

Autores: Daan R.M.G. Ophelders, Ruth Gussenhoven, Luise Klein, Reint K. Jellema, Rob J.J. Westerlaken, Matthias C. Hütten, Jeroen Vermeulen, Guido Wassink, Alistair J. Gunn, Tim G.A.M. Wolfs
Publicado en: Cells, Edición 9/8, 2020, Página(s) 1871, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells9081871

Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: Role of mitochondria, inflammation, and reactive oxygen species

Autores: Syam Nair, Eridan Rocha‐Ferreira, Bobbi Fleiss, Cora H Nijboer, Pierre Gressens, Carina Mallard, Henrik Hagberg
Publicado en: Journal of Neurochemistry, Edición 158/1, 2021, Página(s) 59-73, ISSN 0022-3042
Editor: Blackwell Publishing Inc.
DOI: 10.1111/jnc.15267

Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder

Autores: Camille M. Hours, Sophie Gil, Pierre Gressens
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 15139, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015139

Neonatal encephalopathy and hypoxic–ischemic encephalopathy: moving from controversy to consensus definitions and subclassification

Autores: Eleanor J. Molloy, Aoife Branagan, Tim Hurley, Fiona Quirke, Declan Devane, Petek E. Taneri, Mohamed El-Dib, Frank H. Bloomfield, Beccy Maeso, Betsy Pilon, Sonia L. Bonifacio, Courtney J. Wusthoff, Lina Chalak, Cynthia Bearer, Deirdre M. Murray, Nadia Badawi, Suzann Campbell, Sarah Mulkey, Pierre Gressens, Donna M. Ferriero, Linda S. de Vries, Karen Walker, Sarah Kay, Geraldine Boylan, Chris Gale,
Publicado en: Pediatric Research, Edición 94, 2023, Página(s) 1860-1863, ISSN 0031-3998
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-023-02775-z

Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries

Autores: Bokobza C.*; Jacquens A.*; Guenoun D. ; Bianco B. ; Galland A. ; Pispisa M. ; Cruz A.; Zinni M. ; Faivre V.; Roumier A.; Lebon S.; Vitalis T.; Csaba Z.; Le Charpentier T.; Schwendimann L.; Young-Ten P.; Degos V. ; Monteiro P.; Dournaud P.; Gressens P.; Van Steenwinckel J.
Publicado en: Journal of Neurotransmission, 2022, ISSN 2213-7793
Editor: Springer
DOI: 10.1007/s00702-022-02556-8

Dysregulation of FLVCR1a-dependent mitochondrial calcium handling in neural progenitors causes congenital hydrocephalus

Autores: Francesca Bertino, Dibyanti Mukherjee, Massimo Bonora, Christoph Bagowski, Jeannette Nardelli, Livia Metani, Diletta Isabella Zanin Venturini, Diego Chianese, Nicolas Santander, Iris Chiara Salaroglio, Andreas Hentschel, Elisa Quarta, Tullio Genova, Arpana Arjun McKinney, Anna Lucia Allocco, Veronica Fiorito, Sara Petrillo, Giorgia Ammirata, Francesco De Giorgio, Evan Dennis, Garrett Allington, Fe
Publicado en: Cell Reports Medicine, Edición 5, 2024, Página(s) 101647, ISSN 2666-3791
Editor: Cell Report Medicine
DOI: 10.1016/j.xcrm.2024.101647

Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor

Autores: Hélène Cwerman-Thibault, Vassilissa Malko-Baverel, Gwendoline Le Guilloux, Isabel Torres-Cuevas, Edward Ratcliffe, Djmila Mouri, Virginie Mignon, Bruno Saubaméa, Odile Boespflug-Tanguy, Pierre Gressens, Marisol Corral-Debrinski
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Edición 1870, 2024, Página(s) 167272, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167272

Neuroglobin overexpression in cerebellar neurons of Harlequin mice improves mitochondrial homeostasis and reduces ataxic behavior

Autores: Hélène Cwerman-Thibault, Vassilissa Malko-Baverel, Gwendoline Le Guilloux, Edward Ratcliffe, Djmila Mouri, Isabel Torres-Cuevas, Ivan Millán, Bruno Saubaméa, Virginie Mignon, Odile Boespflug-Tanguy, Pierre Gressens, Marisol Corral-Debrinski
Publicado en: Molecular Therapy, Edición 32, 2024, Página(s) 2150-2175, ISSN 1525-0016
Editor: Nature Publishing Group
DOI: 10.1016/j.ymthe.2024.05.030

Therapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia

Autores: Daniel Alonso-Alconada, Pierre Gressens, Xavier Golay, Nicola J. Robertson
Publicado en: Pediatric Research, Edición 95, 2024, Página(s) 112-119, ISSN 0031-3998
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-023-02751-7

Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis

Autores: Yoann Vial, Jeannette Nardelli, Adeline A Bonnard, Justine Rousselot, Michèle Souyri, Pierre Gressens, Hélène Cavé, Séverine Drunat
Publicado en: EMBO Reports, Edición 25, 2024, Página(s) 2418-2440, ISSN 1469-3178
Editor: EMBO Press
DOI: 10.1038/s44319-024-00123-8

Consequences of General Anesthesia in Infancy on Behavior and Brain Structure

Autores: Jean-Philippe Salaün, Audrey Chagnot, Arnaud Cachia, Nicolas Poirel, Valérie Datin-Dorrière, Cléo Dujarrier, Eloïse Lemarchand, Marine Rolland, Lisa Delalande, Pierre Gressens, Bernard Guillois, Olivier Houdé, Damien Levard, Clément Gakuba, Marine Moyon, Mikael Naveau, François Orliac, Gilles Orliaguet, Jean-Luc Hanouz, Véronique Agin, Grégoire Borst, Denis Vivien
Publicado en: Anesthesia & Analgesia, Edición 136, 2023, Página(s) 240-250, ISSN 0003-2999
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1213/ane.0000000000006233

Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury

Autores: Nicole Labusek 1, Parnian Ghari 1, Yanis Mouloud 2, Christian Köster 1, Eva Diesterbeck 1, Martin Hadamitzky 3, Ursula Felderhoff-Müser 1, Ivo Bendix 1, Bernd Giebel 2, Josephine Herz 4
Publicado en: National Library of Medicine, 2023, Página(s) 20(1):280, ISSN 1742-2094
Editor: BioMed Central
DOI: 10.1186/s12974-023-02961-0

Quantification of brain-wide vascular resistivity via ultrafast Doppler in human neonates helps early detection of white matter injury

Autores: Flora Faure, Jérôme Baranger, Marianne Alison, Béatrice Boutillier, Alice Frérot, Chung Lim, Grégory Planchette, Mickael Prigent, Mickaël Tanter, Olivier Baud, Valérie Biran, Charlie Demené
Publicado en: Journal of Cerebral Blood Flow & Metabolism, 2024, ISSN 0271-678X
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x241232197

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Injury

Autores: Nicole Kaminski, Christian Köster, Yanis Mouloud, Verena Börger, Ursula Felderhoff-Müser , Ivo Bendix, Bernd Giebel and Josephine Herz
Publicado en: Frontiers in Cellular Neurosciences, 2020, Página(s) Vol. 14, ISSN 1662-5102
Editor: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.601176

Neurodevelopmental disorders: research and interventions beyond classifications

Autores: Paul Olivier, Pierre Gressens, Catherine Barthelemy
Publicado en: Journal of Neural Transmission, Edición 130, 2023, Página(s) 181-184, ISSN 0300-9564
Editor: Springer Verlag
DOI: 10.1007/s00702-023-02596-8

Conference proceedings (1)

Ultrasound multiparametric imaging of neuroinflammation

Autores: Ruinet S, Soleimanzad H, Csaba Z, Ialy-Radio N, Bokobza C, Gressens P, Tanter M
Publicado en: 2022
Editor: Society for Neuroscience

Non-peer reviewed articles (1)

Magnetic Isolation of Microglial Cells from Neonate Mouse for Primary Cell Cultures

Autores: Bokobza C.*; Jacquens A.* ; Zinni M. ; Faivre V.; Hua J. ; Guenoun D. ; Userovici C. ; Mani S.; Degos V. ; Gressens P.; Van Steenwinckel J.
Publicado en: JOVE, 2022, Página(s) 185, ISSN 1940-087X
Editor: MYJoVE Corporation
DOI: 10.3791/62964