Human Exposomic Determinants of Immune Mediated Diseases

Livrables

Completion of laboratory analyses of microbiome
Completion of analyses of cortisol and other stress markers
Rapid volatilome method developed for toxicants

Development of a method and system to monitor volatile toxicants based on differential ion mobility spectrometry

Rapid volatilome method developed for microbiome analyses

Development of a method and system to monitor volatile organic compounds related to microbiome andor immunemediated diseases based on differential ion mobility spectrometry as described in Task 7

Multiarray system for antibody screening

Development of portable low cost automatized multiarray system for key biomarkers as described in Task 72

Harmonization of existing data in clinical cohorts

Generation of data matrix including data from clinical cohorts

Identification of additionial end-points in clinical cohorts

The gaps in the end-point data will be filled and the number of end-points will be increased by analyzing islet autoantibodies, transglutaminase autoantibodies, allergen specific IgE, and by registry linkage.

Quality control procedures

Procedures for quality control of laboratory analyses and data integrity

Portable reader for the multiarray system

Development of a portable customized optical reader for the readout of the IncaSlides, as described in Task 7.2.

High throughput immunosignature tool developed

Development of an antigen array for characterization of antibody responses to infections as described in Task 71

Dissemination and Exploitation plan

Plan for dissemination and exploitation of the results and innovations generated by HEDIMED, according to the Tasks of WP11.

Report 4 Joint Network Advisory Board - EPHOR/REMEDIA/HEDIMED

Identify the members, mandate as well rules and work plan for NAB

Definitions and criteria for study endpoints

Generation of definitions and criteria for study end points in all cohorts.

Kick-off report

Report from the kick-off meeting

Final management structure

Finalization of the management team structure that assists and advices the HEDIMED partners regarding administration and reporting and produces necessary reports

Ethical approval report

Ensurement that the all EU regulations (e.g. GDPR) will be followed in the analyses of samples and data in the present consortium

Procedures securing protection of personal data

Protection of personal identity of the study subjects using procedures legally accepted by member states. Creation of anonymized database to allow flexible analyses of the data by consortium members

Creation of publication guidelines

Creation of publication guidelines for the HEDIMED consortium covering scientific publications emerging from the project.

State-of-art report

Comprehensive summary of current scientific state of the research in the field covered by HEDIMED.

Dissemination and Exploitation plan update

Plan update for dissemination and exploitation of the results and innovations generated by HEDIMED according to the Tasks of WP11

Data management plan

Data management plan completed as described in PART B 1.3.2.6 Data management, and Fig.8, and Task 10.4.

Construction of project web site

Construction of HEDIMED project web site

Publications

Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial

Auteurs: Jacub Hurych, Elin Oscarsson, Åsa Håkanson, Kateřina Jirků-Pomajbíková, Milan Jirků, Carin Andrén Aronson, Ondřej Cinek, Daniel Agardh & the HEDIMED Investigator Group
Publié dans: Paracites and Vectors, 2023, ISSN 1756-3305
Éditeur: BioMed Central
DOI: 10.1186/s13071-023-06027-1

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort.

Auteurs: Astrid Sevelsted, Casper-Emil Pedersen, Gözde Gürdeniz, Morten Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jessica Lasky-Su, Andreanne Morin, Carole Ober, Ann-Marie Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes & Hans Bisgaard
Publié dans: eBioMedicine, 2023, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104699

Modulation of the food microbiome by apple fruit processing

Auteurs: Wisnu Adi Wicaksono, Aisa Buko, Peter Kusstatscher, Aki Sinkkonen, Olli H. Laitinen, Suvi M. Virtanen, Heikki Hyöty, Tomislav Cernava, Gabriele Berg
Publié dans: Food Microbiology, Numéro Volume 108, December 2022, 104103, 2022, ISSN 0740-0020
Éditeur: Academic Press
DOI: 10.1016/j.fm.2022.104103

The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut

Auteurs: Wisnu Adi Wicaksono, Tomislav Cernava, Birgit Wassermann, Ahmed Abdelfattah, Maria J. Soto-Giron, Gerardo V. Toledo, Suvi M. Virtanen, Mikael Knip, Heikki Hyöty & Gabriele Berg
Publié dans: Gut Microbes, 2023, ISSN 1949-0984
Éditeur: Taylor and Francis Group
DOI: 10.1080/19490976.2023.2258565

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes

Auteurs: Noora Nurminen, Damiano Cerrone, Jussi Lehtonen, Anirudra Parajuli, Marja Roslund, Maria Lönnrot, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Juho Rajaniemi, Olli H. Laitinen, Aki Sinkkonen, Heikki Hyöty
Publié dans: Diabetes Care, Numéro 44/7, 2021, Page(s) 1506-1514, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc20-1719

Exposomic determinants of immune-mediated diseases : Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach

Auteurs: Laiho, Jutta E; Laitinen, Olli H; Malkamäki, Johannes; Puustinen, Leena; Sinkkonen, Aki; Pärkkä, Juha; Hyöty, Heikki
Publié dans: Environmental Epidemioogy, Numéro 2, 2022, ISSN 2474-7882
Éditeur: Wolters Kluwer Health

Parechovirus Infection in Early Childhood and Association With Subsequent Celiac Disease

Auteurs: German Tapia, Kateřina Chudá, Christian R. Kahrs, Lars C. Stene, Lenka Kramna, Karl Mårild, Trond Rasmussen, Kjersti S. Rønningen, Ondřej Cinek, Ketil Størdal
Publié dans: American Journal of Gastroenterology, Numéro 116/4, 2021, Page(s) 788-795, ISSN 0002-9270
Éditeur: Blackwell Publishing Inc.
DOI: 10.14309/ajg.0000000000001003

A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases : Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children

Auteurs: Marja I. Roslund; Anirudra Parajuli; Nan Hui; Riikka Puhakka; Mira Grönroos; Laura Soininen; Noora Nurminen; Sami Oikarinen; Ondřej Cinek; Lenka Kramná; Anna-Mari Schroderus; Olli H. Laitinen; Tuure Kinnunen; Heikki Hyöty; Aki Sinkkonen; Damiano Cerrone; Mira Grönroos; Olli H. Laitinen; Anna Luukkonen; Iida Mäkelä; Noora Nurminen; Sami Oikarinen; Anirudra Parajuli; Riikka Puhakka; Marja I.
Publié dans: Ecotoxicology and Environmental Safety, Numéro 4, 2022, ISSN 1090-2414
Éditeur: Academic Press Inc.
DOI: 10.1016/j.ecoenv.2022.113900

Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome

Auteurs: Wisnu Adi Wicaksono; Aisa Buko; Peter Kusstatscher; Tomislav Cernava; Aki Sinkkonen; Olli H. Laitinen; Suvi M. Virtanen; Heikki Hyöty; Gabriele Berg
Publié dans: Microbial Ecology, Numéro 2, 2022, ISSN 0095-3628
Éditeur: Springer Verlag
DOI: 10.1007/s00248-022-02157-8

Effects of Lactiplantibacillus plantarum andLacticaseibacillus paracasei supplementation on the faecal metabolome inchildren with coeliac disease autoimmunity: a randomised, double-blindedplacebo-controlled clinical trial.

Auteurs: Eliska Jenickova, Carin Andrén Aronsson, Anna Mascellani Bergo, Ondrej Cinek, Jaroslav Havlik, Daniel Agardh.
Publié dans: Frontiers in Nutrition., 2023, ISSN 2296-861X
Éditeur: Frontiers Media S.A
DOI: 10.3389/fnut.2023.1183963

Atopic sensitization in childhood depends on the type of green area around the home in infancy. Volume53, Issue8, August 2023.

Auteurs: Tiia Voor, Meelis Pärtel, Aleksandr Peet, Liisa Saare, Heikki Hyöty, Mikael Knip, John Davison, Martin Zobel, Vallo Tillmann.
Publié dans: Clinical & Experimental Allergy., 2023, ISSN 1365-2222
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/cea.14317

DNA-directed antigen array for high throughput immunosignature analysis

Auteurs: Barannik Emilia
Publié dans: 2022
Éditeur: Aalto University /CHEM

Immunodetection methods for aflatoxin

Auteurs: Kristiina, Dahl
Publié dans: 2021
Éditeur: Aalto University / CHEM

Cost-Effectiveness of Screening for Celiac Disease in Children.

Auteurs: Mäkinen, Jani
Publié dans: 2023
Éditeur: Aalto University /School of Science

Long chain omega-3 fatty acid intake in pregnancy and risk of type 1 diabetes in the offspring: Two large Scandinavian pregnancy cohorts – MoBa and DNBC

Auteurs: Nicolai A. Lund-Blix, Anne A. Bjerregaard, German Tapia, View ORCID ProfileKetil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I. Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R. Njølstad, View ORCID ProfileSjurdur F. Olsen, View ORCID ProfileLars C. Stene
Publié dans: 2023
Éditeur: medRxiv
DOI: 10.1101/2023.11.23.23297665

Risk Factors for Type 1 Diabetes

Auteurs: Lars C. Stene, Jill M. Norris, and Marian J. Rewers
Publié dans: 2023
Éditeur: National Institute of Diabetes and Digestive and Kidney Diseases

Human intestinal organoid models for celiac disease research

Auteurs: Valeriia Dotsenko; Amir-Babak Sioofy-Khojine; Heikki Hyöty; Keijo Viiri
Publié dans: Celiac Disease ISBN: 9780443192029, Numéro 13, 2023
Éditeur: Elsevier BV
DOI: 10.1016/bs.mcb.2023.01.008

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