Human Exposomic Determinants of Immune Mediated Diseases

Informations projet

HEDIMED

N° de convention de subvention: 874864

DOI

10.3030/874864

Projet clôturé

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 11 992 338,74

Contribution de l’UE

€ 11 992 338,74

Coordonné par

TAMPEREEN KORKEAKOULUSAATIO SR
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Demonstrators, pilots, prototypes (10)

Completion of laboratory analyses of microbiome
Completion of analyses of cortisol and other stress markers
Rapid volatilome method developed for toxicants

Development of a method and system to monitor volatile toxicants based on differential ion mobility spectrometry

Rapid volatilome method developed for microbiome analyses

Development of a method and system to monitor volatile organic compounds related to microbiome andor immunemediated diseases based on differential ion mobility spectrometry as described in Task 7

Multiarray system for antibody screening

Development of portable low cost automatized multiarray system for key biomarkers as described in Task 72

Harmonization of existing data in clinical cohorts

Generation of data matrix including data from clinical cohorts

Identification of additionial end-points in clinical cohorts

The gaps in the end-point data will be filled and the number of end-points will be increased by analyzing islet autoantibodies, transglutaminase autoantibodies, allergen specific IgE, and by registry linkage.

Quality control procedures

Procedures for quality control of laboratory analyses and data integrity

Portable reader for the multiarray system

Development of a portable customized optical reader for the readout of the IncaSlides, as described in Task 7.2.

High throughput immunosignature tool developed

Development of an antigen array for characterization of antibody responses to infections as described in Task 71

Documents, reports (10)

Dissemination and Exploitation plan

Plan for dissemination and exploitation of the results and innovations generated by HEDIMED, according to the Tasks of WP11.

Report 4 Joint Network Advisory Board - EPHOR/REMEDIA/HEDIMED

Identify the members, mandate as well rules and work plan for NAB

Definitions and criteria for study endpoints

Generation of definitions and criteria for study end points in all cohorts.

Kick-off report

Report from the kick-off meeting

Final management structure

Finalization of the management team structure that assists and advices the HEDIMED partners regarding administration and reporting and produces necessary reports

Ethical approval report

Ensurement that the all EU regulations (e.g. GDPR) will be followed in the analyses of samples and data in the present consortium

Procedures securing protection of personal data

Protection of personal identity of the study subjects using procedures legally accepted by member states. Creation of anonymized database to allow flexible analyses of the data by consortium members

Creation of publication guidelines

Creation of publication guidelines for the HEDIMED consortium covering scientific publications emerging from the project.

State-of-art report

Comprehensive summary of current scientific state of the research in the field covered by HEDIMED.

Dissemination and Exploitation plan update

Plan update for dissemination and exploitation of the results and innovations generated by HEDIMED according to the Tasks of WP11

Open Research Data Pilot (1)

Data management plan

Data management plan completed as described in PART B 1.3.2.6 Data management, and Fig.8, and Task 10.4.

Websites, patent fillings, videos etc. (1)

Construction of project web site

Construction of HEDIMED project web site

Publications

Peer reviewed articles (27)

Atopy and asthma in children born to mothers at risk of gestational diabetes mellitus: a follow-up study

Auteurs: Anu Bärenson, Aili Tagoma, Heili Varendi, null null, Raivo Uibo
Publié dans: BMC Pregnancy and Childbirth, Numéro 24, 2024, Page(s) 2024 Sep 19;24(1):610, ISSN 1471-2393
Éditeur: BioMed Central
DOI: 10.1186/s12884-024-06819-y

Impact of urban biodiversity and climate change on children’s health and well being

Auteurs: Hana Seastedt, Jackson Schuetz, Alexandra Perkins, Morgan Gamble, Aki Sinkkonen
Publié dans: Pediatric Research, 2024, ISSN 0031-3998
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41390-024-03769-1

Point-of-Care Fluorescence Biosensing System for Rapid Multi-Allergen Screening

Auteurs: Demuru, Silvia, Hui Chai-Gao, Yevhen Shynkarenko, Nicola Hermann, Patricia-Daiana Boia, Peter Cristofolini, Bradley Petkus, Silvia Generelli, Samantha Paoletti, Stefano Cattaneo and Loïc Burr
Publié dans: Sensors, 2024, ISSN 1424-8220
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s24113280

Effects of Lactiplantibacillus plantarum and Lacticaseibacillus paracasei supplementation on the single-cell fecal parasitome in children with celiac disease autoimmunity: a randomized, double-blind placebo-controlled clinical trial

Auteurs: Jacub Hurych, Elin Oscarsson, Åsa Håkanson, Kateřina Jirků-Pomajbíková, Milan Jirků, Carin Andrén Aronson, Ondřej Cinek, Daniel Agardh & the HEDIMED Investigator Group
Publié dans: Paracites and Vectors, 2023, ISSN 1756-3305
Éditeur: BioMed Central
DOI: 10.1186/s13071-023-06027-1

Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells

Auteurs: Tanja Buchacher, Anni Honkimaa, Tommi Välikangas, Niina Lietzén, M. Karoliina Hirvonen, Jutta E. Laiho, Amir-Babak Sioofy-Khojine, Eeva-Liisa Eskelinen, Heikki Hyöty, Laura L. Elo, Riitta Lahesmaa
Publié dans: iScience, Numéro 25, 2025, Page(s) 103653, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/j.isci.2021.103653

Assessment of Enterovirus Antibodies during Early Childhood Using a Multiplex Immunoassay

Auteurs: N. V. V. Jouppila, J. Lehtonen, E. Seppälä, L. Puustinen, S. Oikarinen, O. H. Laitinen, M. Knip, H. Hyöty, V. P. Hytönen
Publié dans: Microbiology Spectrum, Numéro 11, 2023, ISSN 2165-0497
Éditeur: American Society for Microbiology
DOI: 10.1128/spectrum.05352-22

Incidence Trends of Type 1 Diabetes in Estonian Children (1983–2022) and the Impact of the COVID‐19 Pandemic

Auteurs: Sonja Mattson, Pille Kool, Kaire Heilman, Einberg Ülle, Natalja Liivak, Riina Shor, Mari Lukka, Aleksandr Peet, Vallo Tillmann
Publié dans: Pediatric Diabetes, Numéro 2025, 2025, ISSN 1399-543X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1155/pedi/4967604

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort.

Auteurs: Astrid Sevelsted, Casper-Emil Pedersen, Gözde Gürdeniz, Morten Rasmussen, Jörg Schullehner, Kalliroi Sdougkou, Jonathan W. Martin, Jessica Lasky-Su, Andreanne Morin, Carole Ober, Ann-Marie Schoos, Jakob Stokholm, Klaus Bønnelykke, Bo Chawes & Hans Bisgaard
Publié dans: eBioMedicine, 2023, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104699

Modulation of the food microbiome by apple fruit processing

Auteurs: Wisnu Adi Wicaksono, Aisa Buko, Peter Kusstatscher, Aki Sinkkonen, Olli H. Laitinen, Suvi M. Virtanen, Heikki Hyöty, Tomislav Cernava, Gabriele Berg
Publié dans: Food Microbiology, Numéro Volume 108, December 2022, 104103, 2022, ISSN 0740-0020
Éditeur: Academic Press
DOI: 10.1016/j.fm.2022.104103

Has the Rise of Celiac Disease Incidence in Estonian Children Stopped?

Auteurs: Kärt Simre, Heti Pisarev, Mari‐Liis Kumm, Marie Kaivo, Oivi Uibo
Publié dans: Acta Paediatrica, Numéro 114, 2025, Page(s) 2219-2224, ISSN 0803-5253
Éditeur: Taylor & Francis
DOI: 10.1111/apa.70092

The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut

Auteurs: Wisnu Adi Wicaksono, Tomislav Cernava, Birgit Wassermann, Ahmed Abdelfattah, Maria J. Soto-Giron, Gerardo V. Toledo, Suvi M. Virtanen, Mikael Knip, Heikki Hyöty & Gabriele Berg
Publié dans: Gut Microbes, 2023, ISSN 1949-0984
Éditeur: Taylor and Francis Group
DOI: 10.1080/19490976.2023.2258565

No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

Auteurs: Nicolai A. Lund-Blix, Anne A. Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I. Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R. Njølstad, Sjurdur F. Olsen, Lars C. Stene
Publié dans: Diabetologia, Numéro 67, 2024, Page(s) 1023-1028, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06125-4

Associations of early life dietary diversity and healthy eating with celiac disease: A prospective cohort study

Auteurs: Elin M Hård af Segerstad, Annie Guo, Karl Mårild, Lars C. Stene, Anne Lise Brantsæter, Ketil Størdal
Publié dans: Clinical Nutrition, Numéro 52, 2025, Page(s) 171-178, ISSN 0261-5614
Éditeur: Churchill Livingstone
DOI: 10.1016/j.clnu.2025.07.012

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes

Auteurs: Noora Nurminen, Damiano Cerrone, Jussi Lehtonen, Anirudra Parajuli, Marja Roslund, Maria Lönnrot, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Juho Rajaniemi, Olli H. Laitinen, Aki Sinkkonen, Heikki Hyöty
Publié dans: Diabetes Care, Numéro 44/7, 2021, Page(s) 1506-1514, ISSN 0149-5992
Éditeur: American Diabetes Association
DOI: 10.2337/dc20-1719

Exposomic determinants of immune-mediated diseases : Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach

Auteurs: Laiho, Jutta E; Laitinen, Olli H; Malkamäki, Johannes; Puustinen, Leena; Sinkkonen, Aki; Pärkkä, Juha; Hyöty, Heikki
Publié dans: Environmental Epidemioogy, Numéro 2, 2022, ISSN 2474-7882
Éditeur: Wolters Kluwer Health

Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study

Auteurs: Marja I. Roslund, Anirudra Parajuli, Nan Hui, Riikka Puhakka, Mira Grönroos, Laura Soininen, Noora Nurminen, Sami Oikarinen, Ondřej Cinek, Lenka Kramná, Anna-Mari Schroderus, Olli H. Laitinen, Tuure Kinnunen, Heikki Hyöty, Aki Sinkkonen
Publié dans: Data in Brief, Numéro 47, 2023, Page(s) 109003, ISSN 2352-3409
Éditeur: Elsevier BV
DOI: 10.1016/j.dib.2023.109003

Parechovirus Infection in Early Childhood and Association With Subsequent Celiac Disease

Auteurs: German Tapia, Kateřina Chudá, Christian R. Kahrs, Lars C. Stene, Lenka Kramna, Karl Mårild, Trond Rasmussen, Kjersti S. Rønningen, Ondřej Cinek, Ketil Størdal
Publié dans: American Journal of Gastroenterology, Numéro 116/4, 2021, Page(s) 788-795, ISSN 0002-9270
Éditeur: Blackwell Publishing Inc.
DOI: 10.14309/ajg.0000000000001003

A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases : Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children

Auteurs: Marja I. Roslund; Anirudra Parajuli; Nan Hui; Riikka Puhakka; Mira Grönroos; Laura Soininen; Noora Nurminen; Sami Oikarinen; Ondřej Cinek; Lenka Kramná; Anna-Mari Schroderus; Olli H. Laitinen; Tuure Kinnunen; Heikki Hyöty; Aki Sinkkonen; Damiano Cerrone; Mira Grönroos; Olli H. Laitinen; Anna Luukkonen; Iida Mäkelä; Noora Nurminen; Sami Oikarinen; Anirudra Parajuli; Riikka Puhakka; Marja I.
Publié dans: Ecotoxicology and Environmental Safety, Numéro 4, 2022, ISSN 1090-2414
Éditeur: Academic Press Inc.
DOI: 10.1016/j.ecoenv.2022.113900

Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome

Auteurs: Wisnu Adi Wicaksono; Aisa Buko; Peter Kusstatscher; Tomislav Cernava; Aki Sinkkonen; Olli H. Laitinen; Suvi M. Virtanen; Heikki Hyöty; Gabriele Berg
Publié dans: Microbial Ecology, Numéro 2, 2022, ISSN 0095-3628
Éditeur: Springer Verlag
DOI: 10.1007/s00248-022-02157-8

Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine

Auteurs: Marja I. Roslund, Noora Nurminen, Sami Oikarinen, Riikka Puhakka, Mira Grönroos, Leena Puustinen, Laura Kummola, Anirudra Parajuli, Ondřej Cinek, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-024-68235-8

Antibodies against <i>Clostridium butyricum</i> in the children of mothers at risk for gestational diabetes

Auteurs: Celeste Peterson, Aili Tagoma, Kristi Alnek, Anu Bärenson, Tamara Vorobjova, Ija Talja, Helis Janson, Anne Kirss, Siiri Kõljalg, Aki Sinkkonen, Marja Irmeli Roslund, Raivo Uibo, null null, Eurén Anna, Hyöty Heikki, Kurppa Kalle, Laiho Jutta, Laitinen Olli, Lehtonen Jussi, Lindfors Katri, Lönnrot Maria, Malkamäki Johannes, Numminen Henna, Nurminen Noora, Nykter Matti, Oikarinen Sami, Puustine
Publié dans: Immunological Medicine, 2025, Page(s) 1-11, ISSN 2578-5826
Éditeur: Informa UK Limited
DOI: 10.1080/25785826.2025.2504021

Effects of Lactiplantibacillus plantarum andLacticaseibacillus paracasei supplementation on the faecal metabolome inchildren with coeliac disease autoimmunity: a randomised, double-blindedplacebo-controlled clinical trial.

Auteurs: Eliska Jenickova, Carin Andrén Aronsson, Anna Mascellani Bergo, Ondrej Cinek, Jaroslav Havlik, Daniel Agardh.
Publié dans: Frontiers in Nutrition., 2023, ISSN 2296-861X
Éditeur: Frontiers Media S.A
DOI: 10.3389/fnut.2023.1183963

Using patterns of shared taxa to infer bacterial dispersal in human living environment in urban and rural areas

Auteurs: M. Grönroos, A. Jumpponen, M. I. Roslund, N. Nurminen, S. Oikarinen, A. Parajuli, O. H. Laitinen, O. Cinek, L. Kramna, J. Rajaniemi, H. Hyöty, R. Puhakka, A. Sinkkonen
Publié dans: Applied and Environmental Microbiology, Numéro 90, 2024, ISSN 0099-2240
Éditeur: American Society for Microbiology
DOI: 10.1128/aem.00903-24

Atopic sensitization in childhood depends on the type of green area around the home in infancy. Volume53, Issue8, August 2023.

Auteurs: Tiia Voor, Meelis Pärtel, Aleksandr Peet, Liisa Saare, Heikki Hyöty, Mikael Knip, John Davison, Martin Zobel, Vallo Tillmann.
Publié dans: Clinical & Experimental Allergy., 2023, ISSN 1365-2222
Éditeur: John Wiley & Sons Ltd
DOI: 10.1111/cea.14317

Scoping review on soil microbiome and gut health—Are soil microorganisms missing from the planetary health plate?

Auteurs: Marja I. Roslund, Olli H. Laitinen, Aki Sinkkonen
Publié dans: People and Nature, Numéro 6, 2024, Page(s) 1078-1095, ISSN 2575-8314
Éditeur: Wiley
DOI: 10.1002/pan3.10638

Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child

Auteurs: Leena Hakola, Nicolai A Lund-Blix, Hanna-Mari Takkinen, Heli Tapanainen, Sari Niinistö, Tuuli E Korhonen, Lars C Stene, Heikki Hyöty, Jorma Toppari, Jorma Ilonen, Mikael Knip, Riitta Veijola, Suvi M Virtanen & HEDIMED Investigator group.
Publié dans: Clinical Nutrition ESPEN, 2024, ISSN 2405-4577
Éditeur: European Society for Clinical Nutrition and Metabolism (ESPEN)
DOI: 10.1016/j.clnesp.2024.05.001

Associations of Pregnancy Dietary Quality and Diversity with Childhood Celiac Disease

Auteurs: Elin M Hård af Segerstad, Tiril Cecilie Borge, Annie Guo, Karl Mårild, Lars C Stene, Anne Lise Brantsæter, Ketil Størdal
Publié dans: The Journal of Nutrition, Numéro 154, 2024, Page(s) 3770-3779, ISSN 0022-3166
Éditeur: American Society for Nutritional Sciences
DOI: 10.1016/j.tjnut.2024.10.033

Conference proceedings (2)

Miniaturized Fluorescence Biosensing Reader for Multiplexed Allergen Screening at the Point-Of-Care

Auteurs: Shynkarenko, Yevhen; Chai-Gao, Hui; Demuru, Silvia; Hermann, Nicola; Boia, Patricia-Daiana; Cristofolini, Peter; Petkus, Bradley; Generelli, Silvia; Paoletti, Samantha; Burr, Loïc; Cattaneo, Stefano
Publié dans: Numéro 11, 2023
Éditeur: Zenodo
DOI: 10.5281/zenodo.10103212

Portable Fluorescence Biosensing System for Low-Cost, Quantitative, and Multiplexed Allergen Screening

Auteurs: Hui Chai-Gao, Yevhen Shynkarenko, Silvia Demuru, Nicola Hermann, Patricia-Daiana Boia, Peter Cristofolini, Bradley Petkus, Silvia Generelli, Stefano Cattaneo, Loïc Burr
Publié dans: Eurosensors 2023, 2024, Page(s) 173
Éditeur: MDPI
DOI: 10.3390/proceedings2024097173

Thesis and dissertations (6)

DNA-directed antigen array for high throughput immunosignature analysis

Auteurs: Barannik Emilia
Publié dans: 2022
Éditeur: Aalto University /CHEM

Development of coeliac disease in two populations with different environmental backgrounds

Auteurs: Simre, Kärt
Publié dans: Numéro 23, 2023
Éditeur: Tartu University Press

Immunodetection methods for aflatoxin

Auteurs: Kristiina, Dahl
Publié dans: 2021
Éditeur: Aalto University / CHEM

Cost-Effectiveness of Screening for Celiac Disease in Children.

Auteurs: Mäkinen, Jani
Publié dans: 2023
Éditeur: Aalto University /School of Science

Integrating Gut Microbiome, Metabolomics and Volatilomics To Find Biomarkers Related of Type 1 Diabetes

Auteurs: Erika Antola
Publié dans: 2025
Éditeur: Tampere University

Tools for Studying Human Enteroviruses and the Serological Immune Responses They Elicit

Auteurs: Jouppila, Niila
Publié dans: Numéro 32, 2023
Éditeur: Tampere University

Other (1)

Long chain omega-3 fatty acid intake in pregnancy and risk of type 1 diabetes in the offspring: Two large Scandinavian pregnancy cohorts – MoBa and DNBC

Auteurs: Nicolai A. Lund-Blix, Anne A. Bjerregaard, German Tapia, View ORCID ProfileKetil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I. Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R. Njølstad, View ORCID ProfileSjurdur F. Olsen, View ORCID ProfileLars C. Stene
Publié dans: 2023
Éditeur: medRxiv
DOI: 10.1101/2023.11.23.23297665

Book chapters (2)

Risk Factors for Type 1 Diabetes

Auteurs: Lars C. Stene, Jill M. Norris, and Marian J. Rewers
Publié dans: 2023
Éditeur: National Institute of Diabetes and Digestive and Kidney Diseases

Human intestinal organoid models for celiac disease research

Auteurs: Valeriia Dotsenko; Amir-Babak Sioofy-Khojine; Heikki Hyöty; Keijo Viiri
Publié dans: Celiac Disease ISBN: 9780443192029, Numéro 13, 2023
Éditeur: Elsevier BV
DOI: 10.1016/bs.mcb.2023.01.008